DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ncam1a and Fas2

DIOPT Version :9

Sequence 1:	XP_009293555.1	Gene:	ncam1a / 30447	ZFINID:	ZDB-GENE-990415-31	Length:	1010	Species:	Danio rerio
Sequence 2:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	910	Identity:	246/910 - (27%)
Similarity:	386/910 - (42%)	Gaps:	147/910 - (16%)

- Green bases have known domain annotations that are detailed below.

Zfish    10 TLLFLGYAAALQVEITPTQGEIS---VGESKFFLC-------EVVGDAKEIDWFAPNGEKLLP-- 62
            :|:.|..|.:..:||.|.| |:.   ||:.....|       .:|.|   :.|.......:||
  Fly    21 SLIELTRAQSPILEIYPKQ-EVQRKPVGKPLILTCRPTVPEPSLVAD---LQWKDNRNNTILPKP 81

Zfish    63 -GR--PDISISKTDESSSTLTIYNANVDHAGMYKCVAKSGEKE--SQGTIIVKIFQKLTFQYAPS 122
             ||  |.:........|..|.|.:.:|:..|.|.|.|.....|  .:| :.:|.:..:|:..||.
  Fly    82 NGRNQPPMYTETLPGESLALMITSLSVEMGGKYYCTASYANTEILEKG-VTIKTYVAITWTNAPE 145

Zfish   123 PQEFNEGDDADIICDVISSPPPTIIWRYKKMRIQPETDVRLKVLSNNHLQIRGIKKTDEGDYTCE 187
            .|....|.|..::|:|.:.|.|||.|......|:...|  ..|:..|.|.||.::::|||.|||.
  Fly   146 NQYPTLGQDYVVMCEVKADPNPTIDWLRNGDPIRTTND--KYVVQTNGLLIRNVQESDEGIYTCR 208

Zfish   188 GRIMARGEIDLRVIKVIVNVLPSIRTRYTELNATADINQAVTLACHADGYPEPTVKWARGNTELE 252
            ..::..||:..|.|:|.|.:.|.|.:..|.|.|..  .:.....|.|.|.|.|.:.|.|..|:|.
  Fly   209 AAVIETGELLERTIRVEVFIQPEIISLPTNLEAVE--GKPFAANCTARGKPVPEISWIRDATQLN 271

Zfish   253 --SDEKYSLNEDGSELTIKDVNKLDEGDYKCIARNKAGERSEEVTLNVFVQPKITFLENQTASEL 315
              :.:::.:|.....:||..|::.|.|.|.|:|:|:||...::..|||.|:|:|..|.|.|.:..
  Fly   272 VATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQIYELYNVTGART 336

Zfish   316 EEQITLTCEATGDPTPNIIWSFGRRVFTENEQASWTRPEKHK-SLDGNVVVRSDARVSSLTLKYV 379
            :| |.:||.|.|.|.|.|.:   ||..|:.|..:..:.:..: .|:.|..........:|.:...
  Fly   337 KE-IAITCRAKGRPAPAITF---RRWGTQEEYTNGQQDDDPRIILEPNFDEERGESTGTLRISNA 397

Zfish   380 QFTDAGQYLCTARNSIGQDIQSMYLEVRYAPKIQGPQ---AVFTWEGNPANITCEALAHPGASVL 441
            :.:|.|.|.|.|||......::.::.|.:||.....:   .||:||...||::|.|:..|.|::.
  Fly   398 ERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKANLSCLAMGIPNATIE 462

Zfish   442 WFRDGQQLPSANTTNVKIYNTPTVSFLEVTPDSQNDFGSYNCTATNVIGTESKEFILVQADVPSA 506
            |..:|:::.....||:||..|...|.|.|.|.::..:..|.|.|||:.||...:..|.:|.||..
  Fly   463 WHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPDF 527

Zfish   507 PSIERVEPYSSTAM-IEFEEPASSGGVPVLKYKAEWRIA-GQDWT---------DREYELEDGLN 560
            .|..:....::|.| .:...|::..|:|:|.|..:::.| ..||:         |..|.:|
  Fly   528 VSEAKPSQLTATTMTFDIRGPSTELGLPILAYSVQYKEALNPDWSTAYNRSWSPDSPYIVE---- 588

Zfish   561 LITIVGLKPETTYEVKISAINGKGEGESSAPESFKTQPVRLPFRMSPETPTSIPPTTADIKGEPN 625
                 ||:|:|.|..:.:|.|..|.|.....:...|     |.|.:||.|..:.......|.||
  Fly   589 -----GLRPQTEYSFRFAARNQVGLGNWGVNQQQST-----PRRSAPEEPKPLHNPVQHDKEEP- 642

Zfish   626 PPKLEAKPQSTGNEMKVHFIKQDDGGSPIKHYLVRY--RAKNRQDWKP--------EIRMPDASD 680
               :...|.|  :..::.:....|.|.||..|.::|  ..|....|..        |:....:.:
  Fly   643 ---VVVSPYS--DHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSCNTVEVMETTSFE 702

Zfish   681 YIVLRGLDWNTEYEVYVIAENQRGRSEPGTLSFRTLPEPTAIPETSSGL-----------GTGAI 734
            ...|.|   ||.|.:.:.|.|..|.|.|.::          |.:|:.|:           .:.||
  Fly   703 MTQLVG---NTYYRIELKAHNAIGYSSPASI----------IMKTTRGIDVIQVAERQVFSSAAI 754

Zfish   735 VGILIVVFILLLFGVDVTCYFLNKCGLLMCIAVN------FCGKSGPSAKSKDIEEGKAAFTKDE 793
            |||.|...:||||.||:.|          ||.|:      .|.|:..|....|          ||
  Fly   755 VGIAIGGVLLLLFVVDLLC----------CITVHMGVMATMCRKAKRSPSEID----------DE 799

Zfish   794 SK----------EPIVEVRTEEERTPN--------HEGGGP--TEPNETTPLTDPEHAADTTATV 838
            :|          .|....:..:|..|:        ..||.|  |..:|..||..|..:....:|:
  Fly   800 AKLGSLYGWRFPLPYCSGQLVKEPPPSPLPLPPPVKLGGSPMSTPLDEKEPLRTPTGSIKQNSTI 864

Zfish 839 838
Fly 865 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncam1a	XP_009293555.1	Ig	20..112	CDD:299845	27/108 (25%)
		I-set	21..111	CDD:254352	26/106 (25%)
		IG_like	121..200	CDD:214653	26/78 (33%)
		IGc2	128..189	CDD:197706	22/60 (37%)
		Ig	208..301	CDD:299845	29/94 (31%)
		IG_like	219..298	CDD:214653	23/80 (29%)
		Ig	300..406	CDD:299845	29/106 (27%)
		IG_like	308..406	CDD:214653	25/98 (26%)
		ig	413..498	CDD:278476	28/87 (32%)
		IG_like	415..498	CDD:214653	28/85 (33%)
		fn3	505..589	CDD:278470	23/94 (24%)
		FN3	624..715	CDD:238020	22/100 (22%)
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	23/98 (23%)
		IG_like	144..226	CDD:214653	29/83 (35%)
		IGc2	152..209	CDD:197706	22/58 (38%)
		I-set	230..319	CDD:254352	27/90 (30%)
		IGc2	243..309	CDD:197706	19/67 (28%)
		IG_like	330..424	CDD:214653	25/97 (26%)
		IGc2	339..412	CDD:197706	21/75 (28%)
		Ig	447..518	CDD:143165	24/70 (34%)
		fn3	534..611	CDD:278470	22/85 (26%)
		FN3	640..735	CDD:238020	24/113 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11557
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40754
Inparanoid	1	1.050	273	1.000	Inparanoid score	I2951
OMA	1	1.010	-	-		QHG48678
OrthoDB	1	1.010	-	-		D129648at2759
OrthoFinder	1	1.000	-	-		FOG0002001
OrthoInspector	1	1.000	-	-		otm25496
orthoMCL	1	0.900	-	-		OOG6_103800
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.740