Protein Alignment brd2a and fs(1)h

DIOPT Version :9

• Sequence 1: NP_571275.2
• Gene: brd2a / 30445
• ZFINID: ZDB-GENE-990415-248
• Length: 836
• Species: Danio rerio
• Sequence 2: NP_001259321.1
• Gene: fs(1)h / 31722
• FlyBaseID: FBgn0004656
• Length: 2046
• Species: Drosophila melanogaster
• Alignment Length: 1176
• Identity: 406/1176 - (34%)
• Similarity: 512/1176 - (43%)
• Gaps: 466/1176 - (39%)

Zfish    46 FEGPALPHIAQSGPPQPAVRDPS-RQGRMTNQLQFLQKALVKTLWRHHFAWPFHEPVDAAKLNLP 109
            :|.|..|   .:|..||.|..|: |.||.|||||:|.|.::|.:|:|||:|||.:||||.|||||
  Fly    10 YEPPVEP---VNGIVQPPVIPPAERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDAKKLNLP 71

Zfish   110 DYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKAFLQK 174
            ||:.||||||||||||||||||||.||.|.:|||||||.|||:||||.:|:|:|||:|||.||||
  Fly    72 DYHKIIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLEKVFLQK 136

Zfish   175 VAQMPEVEEEIPAPVPRGKQSK------PKK---GQKLFSGGITTAHQVP------------AIS 218
            :..||:.|.|:.....:|.:.|      ||.   |....:|..|::..|.            |.|
  Fly   137 IESMPKEELELEPVTAKGGKKKQRAPATPKSSSGGAGASTGSGTSSAAVTSGPGSGSTKVSVAAS 201

Zfish   219 SLSQLAY---------SPPTPDT-PDS-----------------VLST-------------PPQT 243
            |..|...         |..||.| |.|                 |.||             ||.|
  Fly   202 SAQQSGLQGATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSSTAGGAPSIPPISTMPPHT 266

Zfish   244 L--------------------------------------ITKNFPPPP----LHSTPALLG---- 262
            :                                      .|..:|..|    ::|:..|.|
  Fly   267 VPGSTNTTTTAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVNSSSLLDGSTAA 331

Zfish   263 ------------------------------------------------------LPPTQPTAKKK 273
                                                                  :||.||...||
  Fly   332 VAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAVIPPQQPAKIKK 396

Zfish   274 GVKRKADTTTPTTTVMPLTLGVGGMGMGMGMGMSMGMGMGMGLGGDSPLTLSNMGMDSKQSLSLS 338
            ||||||||||||....                             :||.|    .||||.:
  Fly   397 GVKRKADTTTPTANAF-----------------------------ESPYT----QMDSKSA---- 424

Zfish   339 LGMSLEDKVPARR---------GGSGRPIKP-PRKDLPD--------------SQNQHQPVRRGK 379
                   |:..||         .|||..:.| ....:|.              ::|:.      |
  Fly   425 -------KIATRRESNRQVIGKKGSGYNMSPLGVSGVPGLGGLVAGGVAGVAVAKNKE------K 476

Zfish   380 LSQQLRYCSTILKELLSKKHTAYAWPFYKPVDVSSLGLHDYYDIIMYPMDLSTIKRKMDHREYRD 444
            ||..|:.|:.|||||.||||:.||||||||||...||||||:|||..||||.|:|||||:|||:.
  Fly   477 LSDALKSCNEILKELFSKKHSGYAWPFYKPVDAEMLGLHDYHDIIKKPMDLGTVKRKMDNREYKS 541

Zfish   445 ALQFAADVRLMFSNCYKYNPPDHDVVAMARRLQDVFEFRFAKMPDEPLESLP------------- 496
            |.:|||||||:|:|||||||||||||||.|:||||||.|:|.:||||:.:..
  Fly   542 APEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDVFEMRYANIPDEPVANAAHHHGHGHGHGHGH 606

Zfish   497 --------PASLGGGLGGDSSSSSSSSSSSSESDVSSESESESSPSSDSEEERAHRLAQLQEQVC 553
                    ....|.|.||.||....:|.||||.  ||::|:|    |:|:|||:.||..|:
  Fly   607 GHGHGHGHGHGHGHGYGGSSSLKHDASDSSSED--SSDTENE----SNSDEERSARLKMLE---- 661

Zfish   554 TQLRAVHEQLAALSSTPIIKPKKKKEKKDKKK-------KKKPEKHKRSR--------------- 596
            ::|..:.|::..||.....|.|.||:.|:|||       ......|..:.
  Fly   662 SKLLGLQEEIRKLSEEASAKKKAKKKLKEKKKSIGGGSGSGSASHHCHATGGGANAGGAGGPGSG 726

Zfish   597 ------------------------------SVIEDEVVMRPAKIPKL------------------ 613
                                          |::..........:|.:
  Fly   727 GHGSVSVPGGVGSLGPGGAGGANLNALLGGSLVGHGGAAVAGGVPNVGALHSQVHDVAMAFSQMA 791

Zfish   614 -------------------------------------------------PKTPKSR--------- 620
                                                             .|..||:
  Fly   792 GGGAAAGAGFGAGVTAAGASSGGKAGTLAGALAAGAAAGAGGTTAGSGSSKGAKSKGGRGAKGSG 856

Zfish   621 ------SNSKAA------------------------------TSTQSKKSSNK-------KSNKS 642
                  ||:.||                              .|.::|.||:.       .:|.|
  Fly   857 AGGVGASNNAAAGNAAGGAAGAAAGAGSVGGVGGAGAAGGGNASKRAKGSSSAGAGGGVGGANAS 921

Zfish   643 ------KSSKKAQPTFFPPPLSHSGLTPHYDSEEEEETSPMSYDEKRQLSLDINRLPGEKLGRVV 701
                  :.|.|.:|:          ...::|||||:...|||||||||||||||:|||:||||||
  Fly   922 AGGAGARGSSKKKPS----------QVMNFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVV 976

Zfish   702 HIIQSREPSLRDTNPEEIEIDFETLKPSTLRELERYVMMCLRKKP-RKPFVAIKGSAGKSREELA 765
            ||||:|||||||:||:||||||||||||||||||.||..|||||. :||       :|||::|..
  Fly   977 HIIQNREPSLRDSNPDEIEIDFETLKPSTLRELESYVASCLRKKTHKKP-------SGKSKDEQM 1034

Zfish   766 LEKKRELERRLQDVSGQLNSVKKPQKTKAEKPSAVEPHAVASRLSASSSSSDSSSSSSS-SSSSD 829
            .|||:|||:|||||:|||.:.||..|......|.||....|:.:|:||||||||||||| |||||
  Fly  1035 AEKKQELEKRLQDVTGQLGASKKTAKKDESASSKVEAVQPANPVSSSSSSSDSSSSSSSDSSSSD 1099

Zfish   830 TSESDS 835
            :|:|::
  Fly  1100 SSDSEA 1105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brd2a	NP_571275.2	Bromo_Brdt_I_like	72..178	CDD:99929	76/105 (72%)
		Bromo_Brdt_II_like	383..484	CDD:99930	74/100 (74%)
		BET	676..738	CDD:293640	55/61 (90%)
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	76/105 (72%)
		COG5076	387..>593	CDD:227408	117/255 (46%)
		Bromo_Brdt_II_like	481..581	CDD:99930	74/99 (75%)
		BET	951..1015	CDD:293640	57/63 (90%)
		BRD4_CDT	<2026..2046	CDD:293710

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	152	1.000	Domainoid score	I4284
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	1	1.000	-	-		otm24226
orthoMCL	1	0.900	-	-		OOG6_100249
Panther	1	1.100	-	-	LDO	PTHR22880
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3378
SonicParanoid	1	1.000	-	-		X197
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.800