DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nr2f5 and usp

DIOPT Version :9

Sequence 1:	NP_571261.1	Gene:	nr2f5 / 30427	ZFINID:	ZDB-GENE-990415-253	Length:	403	Species:	Danio rerio
Sequence 2:	NP_001259168.1	Gene:	usp / 31165	FlyBaseID:	FBgn0003964	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	454	Identity:	146/454 - (32%)
Similarity:	206/454 - (45%)	Gaps:	107/454 - (23%)

- Green bases have known domain annotations that are detailed below.

Zfish    16 PGSQLQMCSQEPGG------TPGTPSGST--------PGNDALSGDKIPNVDCMVCGDKSSGKHY 66
            |||.....:....|      .|.:..||.        |.|..|||.|..   |.:|||::|||||
  Fly    55 PGSNSASSNNNSAGDAQMAQAPNSAGGSAAAAVQQQYPPNHPLSGSKHL---CSICGDRASGKHY 116

Zfish    67 GQFTCEGCKSFFKRSVRRNLSYTCRGNRDCPIDQHHRNQCQYCRLKKCLKVGMRREAVQR----- 126
            |.::|||||.||||:||::|:|.||.||:|.||:..||:|||||.:|||..||:|||||.
  Fly   117 GVYSCEGCKGFFKRTVRKDLTYACRENRNCIIDKRQRNRCQYCRYQKCLTCGMKREAVQEERQRG 181

Zfish   127 -----GRMSNS---QSSPGQY-------------LSNGSDPYNG-QPYLSGFIS----------- 158
                 ||:|.|   .|.||..             :|.|....|| ..:::..:|
  Fly   182 ARNAAGRLSASGGGSSGPGSVGGSSSQGGGGGGGVSGGMGSGNGSDDFMTNSVSRDFSIERIIEA 246

Zfish   159 -------------LLLRAEPYPTSRYGAQCMQSNNLMGIENICELAARLLFSAVEWAKNIPFFPD 210
                         ..||..||.|       :|.:....:..:|::..:.||..||:|:.:|.|..
  Fly   247 EQRAETQCGDRALTFLRVGPYST-------VQPDYKGAVSALCQVVNKQLFQMVEYARMMPHFAQ 304

Zfish   211 LQLMDQVALLRMSWSELFVLNAAQCSM-----------------------------PLHVAPLLA 246
            :.|.|||.||:.:|.||.:.|.|.||:                             |..:. |..
  Fly   305 VPLDDQVILLKAAWIELLIANVAWCSIVSLDDGGAGGGGGGLGHDGSFERRSPGLQPQQLF-LNQ 368

Zfish   247 AAGLHASPMSAERVVAFMDHIRVFQEQVEKLKALQVDTAEYSCLKSIVLFTSDAMGLSDVAHVES 311
            :...|.:......|.|..|  |:..|...|:|.|.:|..|.||||:|:|:..|..|:...|.:|.
  Fly   369 SFSYHRNSAIKAGVSAIFD--RILSELSVKMKRLNLDRRELSCLKAIILYNPDIRGIKSRAEIEM 431

Zfish   312 IQEKSQCALEEYVRNQYPNQPNRFGRLLLRLPSLRIVSSPVIEQLFFVRLVGKTPIETLLRDML 375
            .:||....|:|:.|.::|....||.:||||||:||.:|....:.||..|:....|:|.|..:.|
  Fly   432 CREKVYACLDEHCRLEHPGDDGRFAQLLLRLPALRSISLKCQDHLFLFRITSDRPLEELFLEQL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nr2f5	NP_571261.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..44		9/41 (22%)
		NR_DBD_COUP_TF	54..126	CDD:143516	46/71 (65%)
		NR_LBD_COUP-TF	152..387	CDD:132746	75/277 (27%)
usp	NP_001259168.1	NR_DBD_RXR	102..178	CDD:143514	47/78 (60%)
usp	NP_001259168.1	NR_LBD_RXR_like	237..480	CDD:132741	69/252 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577452
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840