DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzd7b and fz

DIOPT Version :9

Sequence 1:	NP_739569.1	Gene:	fzd7b / 30412	ZFINID:	ZDB-GENE-990415-229	Length:	557	Species:	Danio rerio
Sequence 2:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster

Alignment Length:	583	Identity:	270/583 - (46%)
Similarity:	364/583 - (62%)	Gaps:	46/583 - (7%)

- Green bases have known domain annotations that are detailed below.

Zfish    11 VYKTYCVFITTLLFGL---------SSAQYHGEKGI---------SVPEHGFCQPISIPLCTDIQ 57
            :::.....:.||:.|:         :|..|....|:         .:|.|..|:||:|.:|.:|.
  Fly     1 MWRQILFILPTLIQGVQRYDQSPLDASPYYRSGGGLMASSGTELDGLPHHNRCEPITISICKNIP 65

Zfish    58 YNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSQDLKFFLCSMYAPVCTVLEQAIPPCRTLCER 122
            ||.||||||:|||.||:||||||||.||||:.||.||:.||||:|.||||:||:.|||||:|||.
  Fly    66 YNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLCES 130

Zfish   123 ARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNKSDPDVPTTNPTPYIPEPFSPR----I 183
            ||. ||.||..:.|.|||.|.|..|||||..::||.:|.:........||..:.:..:.:    :
  Fly   131 ARV-CEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTAATPTRSVAKVTTRKHQTGV 194

Zfish   184 HTPRQNQAFTCPLQLTVPSYLNYHF-LGAK---NCGAPCEHKQPYGLMYFKEEEVRFGRLWVGIW 244
            .:|.:|..|.||:||..|..:.|.. :|.|   :|||||.      .|:|.|.|....|.|||.|
  Fly   195 ESPHRNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCH------AMFFPERERTVLRYWVGSW 253

Zfish   245 SILCCVSTLFTVLTYLVDMRRFHYPERPIIFLSGCYFMVAVAYAAGFLLEDKVVCIDKF------ 303
            :.:|..|.||||||:|:|..||.||||.|:||:.||.:|..||.||....|.|.|.:.|
  Fly   254 AAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAGDSVSCREPFPPPVKL 318

Zfish   304 -RDDAFKTVAQGTKK-EGCTILFMVLYFFGMASSIWWVILSLTWFLSAGMKWGHEAIEANSQYFH 366
             |.....|:.||.:: ..||:|||.|||..||:..||..|:..|||:||:||||||||..|..||
  Fly   319 GRLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFH 383

Zfish   367 LAAWAVPAVKTITILALGQVDGDLLTGVCYVGIYNVDALRGFVLAPLFVYLFIGTSFLLAGFVSL 431
            |.||||||::||::|||.:|:||:|:|||:||..:..:|..|::.||.:||.||..||||||:||
  Fly   384 LVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAFLILPLCIYLSIGALFLLAGFISL 448

Zfish   432 FRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFREQWEKTWHMQTCKRFA 496
            |||||:||.||.:|:|||:||:|||.||.|:.:||..::.|.|||....::|...||...||.|:
  Fly   449 FRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFS 513

Zfish   497 VPCPNNNFAPMTPD----FTVFMIKYLMTMIVGITSGFWIWSGKTLQSWRRFYKRLGNNQGET 555
            :|||... ||.:|:    |.:||:|||.:|:||:||..|::|.||:.|||.|.:||...:..|
  Fly   514 IPCPAAR-APGSPEARPIFQIFMVKYLCSMLVGVTSSVWLYSSKTMVSWRNFVERLQGKEPRT 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzd7b	NP_739569.1	CRD_FZ1_like	43..161	CDD:143567	73/117 (62%)
fzd7b	NP_739569.1	Frizzled	228..545	CDD:279827	165/328 (50%)
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	73/116 (63%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827	165/327 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4077
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20750
Inparanoid	1	1.050	548	1.000	Inparanoid score	I1115
OMA	1	1.010	-	-		QHG48699
OrthoDB	1	1.010	-	-		D167933at33208
OrthoFinder	1	1.000	-	-		FOG0001848
OrthoInspector	1	1.000	-	-		otm24936
orthoMCL	1	0.900	-	-		OOG6_104642
Panther	1	1.100	-	-	O	PTHR11309
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3233
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.870