DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pou3f2b and Antp

DIOPT Version :9

Sequence 1:	NP_571235.1	Gene:	pou3f2b / 30397	ZFINID:	ZDB-GENE-980526-370	Length:	378	Species:	Danio rerio
Sequence 2:	NP_996167.1	Gene:	Antp / 40835	FlyBaseID:	FBgn0260642	Length:	378	Species:	Drosophila melanogaster

Alignment Length:	363	Identity:	67/363 - (18%)
Similarity:	103/363 - (28%)	Gaps:	172/363 - (47%)

- Green bases have known domain annotations that are detailed below.

Zfish    74 PLGEQDIKPAVQSPRDEMHNSSNLQHQSRPPHLVHQ-THGNHHDSRAWRTTTAAHIPSMATSNGQ 137
            |...|..:.|.|:|:         |.|.:.|.:..| ||......                   |
  Fly   119 PSQNQQQQQAQQAPQ---------QLQQQLPQVTQQVTHPQQQQQ-------------------Q 155

Zfish   138 SLIYS----QPSFSVNGLIPGSG--------QGIH--------HH----------------SMRD 166
            .::|:    |.:....|::|..|        .|.|        ||                .:.:
  Fly   156 PVVYASCKLQAAVGGLGMVPEGGSPPLVDQMSGHHMNAQMTLPHHMGHPQAQLGYTDVGVPDVTE 220

Zfish   167 AHEDHHSPHLSDH-------GHPPSQHQHQSH---QSHHDHSDEDTPTSDD-------------- 207
            .|::||:..:...       |.||....||..   |.|..|..:.||.|.:
  Fly   221 VHQNHHNMGMYQQQSGVPPVGAPPQGMMHQGQGPPQMHQGHPGQHTPPSQNPNSQSSGMPSPLYP 285

Zfish   208 --LEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWL 270
              ..||.|..:::|                      .:.|..|::.|:
  Fly   286 WMRSQFGKCQERKR----------------------GRQTYTRYQTLE----------------- 311

Zfish   271 EEADSTSGSPTSLDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPAASEITSLADSLQLEKEV 335
                        |:|.....|...:|..||:                        |.:|.|.:..
  Fly   312 ------------LEKEFHFNRYLTRRRRIEI------------------------AHALCLTERQ 340

Zfish   336 VRVWFCNRRQK-EKRMTPPGGPLPGTEDVYGD--TPPH 370
            :::||.|||.| :|.....|.|..|.|   ||  |||:
  Fly   341 IKIWFQNRRMKWKKENKTKGEPGSGGE---GDEITPPN 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pou3f2b	NP_571235.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	86..118		7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..205		19/95 (20%)
		POU	200..274	CDD:197673	10/89 (11%)
		Homeobox	295..348	CDD:278475	12/53 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..378		10/26 (38%)
Antp	NP_996167.1	KLF1_2_4_N	<161..306	CDD:425360	27/166 (16%)
Antp	NP_996167.1	Homeobox	301..354	CDD:395001	18/105 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030