DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyp19a1a and Cyp313a4

DIOPT Version :9

Sequence 1:	NP_571229.3	Gene:	cyp19a1a / 30390	ZFINID:	ZDB-GENE-990415-43	Length:	517	Species:	Danio rerio
Sequence 2:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster

Alignment Length:	490	Identity:	108/490 - (22%)
Similarity:	197/490 - (40%)	Gaps:	88/490 - (17%)

- Green bases have known domain annotations that are detailed below.

Zfish    40 CGATATILLLLLCLLLAIRHHRPHKSHIPGPSFFFGLG-PVVSYCRFIW--SGIGTASNYYNSKY 101
            ||   .:.||.:..|.:.|........||||     || |::....::.  ..|..|...:..|:
  Fly     8 CG---LLFLLWIYFLWSRRRFYLLTLKIPGP-----LGYPILGMAHWLMRREDILNAFGCFLDKH 64

Zfish   102 GDIVRVWINGEETLILSRSSAVYHVLRKSLYTSRFGSKLGLQCIGMHEQGIIF-----NSNVALW 161
            |..:..|:.....:|:|....|     :.::||.       .|:   .:|||:     .:.|.|:
  Fly    65 GPTIFSWLGPIPFMIVSDPQVV-----QDIFTSP-------HCV---NKGIIYKAVDDGAGVGLF 114

Zfish   162 --KKVRAFYAKALTGPG-----LQRTMEICTTSTNSHLDDLSQLTDAQGQLDILNLLRCIVVDVS 219
              |..|....:.|..|.     |...:.|....|...||.|..|.| .|:.|::.||:...:.::
  Fly   115 SLKDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQD-DGEKDLIPLLQSFTLGIA 178

Zfish   220 NRLFLGVPLNEHD------LLQKIHKYFDTWQTVLIKPDVYFRLDWLHKK----------HKRDA 268
            .:..:|..:.:.:      ||.:.....:|...:...|       ||:.:          |...|
  Fly   179 TQTTMGSDVKDEESFRSNSLLGRYQCILETMTDMCFSP-------WLNSRFCRQLAGKESHYYQA 236

Zfish   269 Q-ELQDAITALIEQKKVQ--------LAHAEKLDHLDFTAELIFAQSHGELSAENVRQCVLEMVI 324
            : |::..|..:||:|..:        :...:|...|:...:|:   ..|..:.:||......:|.
  Fly   237 KTEIRQFIRKIIERKLAEDEMGALPSIQSNDKNLFLNLVTDLM---RRGVFTLKNVEDESNIIVF 298

Zfish   325 AAPDTLSISLFFMLLLLKQNPDVELKILQEMDSVLAGQ---SLQHSHLSKLQILESFINESLRFH 386
            .|.:|.:.::::.|:||...|:.:.:..:|:.::....   .:.::...::..|:..:|||:|..
  Fly   299 GAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLILNESMRVI 363

Zfish   387 PVVDFTMRRALDD-DVIEGYNVKKGTNIILNVGRMHRS--------EFFSKPNQFSLDNFHKNVP 442
            |.|....|:...| .:..|..|.||..|.:::..||||        |.|: |:.|...|.....|
  Fly   364 PPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFN-PDHFLPHNIQDKHP 427

Zfish   443 SRFFQPFGSGPRSCVGKHIAMVMMKSILVALLSRF 477
            ..:. ||..|.|:|:|...|::..|..|..||..:
  Fly   428 YAYI-PFTKGIRNCIGWRYALISAKVTLAKLLRNY 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyp19a1a	NP_571229.3	None
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	101/462 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910