DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyp19a1a and Cyp4d20

DIOPT Version :9

Sequence 1:	NP_571229.3	Gene:	cyp19a1a / 30390	ZFINID:	ZDB-GENE-990415-43	Length:	517	Species:	Danio rerio
Sequence 2:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	126/546 - (23%)
Similarity:	214/546 - (39%)	Gaps:	121/546 - (22%)

- Green bases have known domain annotations that are detailed below.

Zfish    47 LLLLLCLLLAIRHHRP---HKSHIPGPSFFFGLGPVVSYCRFIWSGIGTASNYYN------SKYG 102
            |:|||......:..|.   .||.||||.....||     |......:| |.|...      .|||
  Fly    10 LILLLTWDFGRKRQRVLAFEKSAIPGPISIPILG-----CGLQALHLG-AENIIGWVGEKFDKYG 68

Zfish   103 DIVRVWINGE-----------ETLI----LSRSSAVYHVLRKSLYTSRFGSKLGLQCIGMHEQGI 152
            ...|.||.||           ||::    |.....:|..||..|                 ..|:
  Fly    69 KTFRFWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRPFL-----------------NDGL 116

Zfish   153 IFNSNVALWKKVRAFYAKALTGPGLQRTMEICTTSTNSHLDDLSQLTDAQGQLDILNLLRCIVVD 217
            :.::. ..|...|..:..|.....|:..:||....::..:|:|.::.|.:..:|:|..:....:|
  Fly   117 LVSTG-RKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALD 180

Zfish   218 VSNRLFLGVPLNEHDLLQKIHKYFDTWQTVL-IKPDVYFRL----DW--------LHKKHKRDAQ 269
            |.....:||.:|..:  .....|....::|: |:||..||.    :|        ||::...|.:
  Fly   181 VITEAAMGVQVNAQN--DPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPLLHRQLLSDIR 243

Zfish   270 ELQDAITALIEQKK--------------VQLAHAE-----KLDHLDFTAELIFAQS---HGELSA 312
            .:.|....:|.:::              :.|..||     ::..||     |..||   :..||.
  Fly   244 VMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLD-----ILLQSSINNQPLSD 303

Zfish   313 ENVRQCVLEMVIAAPDTLSISLFFMLLLLKQNPDVELKILQEMDSVL---AGQSLQHSHLSKLQI 374
            .::|:.|...:....||.|..:...|..:.::|:|:.:|.:|:..||   |...:..:.|..|:.
  Fly   304 ADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKY 368

Zfish   375 LESFINESLRFHPVVDFTMRRALDDDVIEGYNVKKGTNIILNVGRMHR-SEFFSKPNQFSLDNFH 438
            |:..|.|::|.:|.|....|.|..:..|....:...|:|.|.:...|| :.:|..|..|.
  Fly   369 LDCVIKETMRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFR----- 428

Zfish   439 KNVPSRFFQ------------PFGSGPRSCVGKHIAMVMMKSILVALLSRFSVCPMKACTVENIP 491
               |.||.:            ||.:||::|:|:..|::.||.::..:|..:.:.|:..   |..|
  Fly   429 ---PERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGE---ELKP 487

Zfish   492 QTNNLSQQPVEEPSSLSVQLILRNTL 517
            ..|.:    :...|.::|.|..|..|
  Fly   488 MLNFI----LRSASGINVGLRPRKAL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyp19a1a	NP_571229.3	None
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	113/504 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589901
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950