Protein Alignment Cpn2 and Fili

DIOPT Version :10

• Sequence 1: NP_001100555.2
• Gene: Cpn2 / 303861
• RGDID: 1305170
• Length: 565
• Species: Rattus norvegicus
• Sequence 2: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Alignment Length: 534
• Identity: 135/534 - (25%)
• Similarity: 210/534 - (39%)
• Gaps: 121/534 - (22%)

  Rat    29 WLCWA----SLLLLVRVTQP------CPVGCDCF----DRKIFCSDEQLAAIPLDIPSH------ 73
            |||.|    .||||..|..|      ||..|.|.    :.:..|.|..|..:|:.:...
  Fly    16 WLCGAIPVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINL 80

  Rat    74 -VTDIVFVETS----------------FTTVGTRAFSGSPNLTKVVFLNTRVHHLEPDAFGGLPR 121
             |..|..:|.|                ..|:|::.|.....|..:......|..|...||.||..
  Fly    81 TVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTN 145

  Rat   122 LEDLEVTGSPFSNLSANIFSNLSSLGKLTLDFNRLAALPEDLFHHMDTLESLQLQGNQLQTLPGR 186
            |..|:::.:....:.....|:|:||.:|.|..|.:.:|.::.|..|:|||.|..:.|:|..:|..
  Fly   146 LLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPAS 210

  Rat   187 LFQSLRYLRTLNLAQNLLTQLPKGMFQSLSSLQILKLSDNMFARLPEGVLSNLGSLQELFLDSNA 251
            ....|..|::|:::.||:..:....|:.|.  ::|.||                      :..|.
  Fly   211 NLWHLHALKSLDMSLNLVEFVRNDSFEGLK--ELLALS----------------------VQGNV 251

  Rat   252 ITELSPHLFSHLLSLEKLWLQHNAISLLPVSAFSSLRNLTFLNLKDNALRTLPAGLFTHNPGLLH 316
            ::||....|..|:||:.|.|..|.::::|....|.|.|||:|||..|....|||..|.:...|..
  Fly   252 MSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRE 316

  Rat   317 LSLS-YNQLETVPEGSFANLRKLASLTLSHN-AITHLPENVFRNLEQLVKLSLDSNNLTVLHPTL 379
            |.|| .:.|:.:...:|.:...|.:|.|::| .::.:|..:|:....::::.:.||:|..|:...
  Fly   317 LHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQ 381

  Rat   380 F--HNLSKLQLLDLSRNQLTMLPGGIFDTNYDLFNLALLGNPWQCDCRLSYLTSWLRLYNDRIFN 442
            |  ..|.||.|.|                           ||.||:|.|.:|  | ||...   |
  Fly   382 FPVDQLQKLYLGD---------------------------NPLQCNCSLLWL--W-RLVTG---N 413

  Rat   443 THTFCAGPAYLKGQLVPNLKQEQLVCPGNPGQLGLDDREPAGSWDLAVEGRAAHRQCIYGNPEGT 507
            ......|..:..|..|..|.:|            .||.|      ||.|..|     :....:|.
  Fly   414 FEGVDPGMEHAAGGAVAALAKE------------ADDEE------LADEATA-----VASTDDGV 455

  Rat   508 VLLACEEAQCRWLN 521
            ..||...|:...:|
  Fly   456 AALAAYIAEQHIVN 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpn2	NP_001100555.2	LRRNT	44..75	CDD:214470	9/47 (19%)
		leucine-rich repeat	77..97	CDD:275380	6/35 (17%)
		LRR	118..418	CDD:443914	77/303 (25%)
		leucine-rich repeat	122..145	CDD:275380	4/22 (18%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		leucine-rich repeat	170..193	CDD:275380	7/22 (32%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..241	CDD:275380	3/22 (14%)
		leucine-rich repeat	242..265	CDD:275380	5/22 (23%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	10/22 (45%)
		leucine-rich repeat	314..337	CDD:275380	6/23 (26%)
		leucine-rich repeat	338..361	CDD:275380	6/23 (26%)
		leucine-rich repeat	362..383	CDD:275380	5/22 (23%)
		leucine-rich repeat	386..405	CDD:275380	3/18 (17%)
		PCC	390..>499	CDD:188093	24/108 (22%)
Fili	NP_001369108.1	LRR	71..>348	CDD:443914	76/300 (25%)
		leucine-rich repeat	75..97	CDD:275378	4/21 (19%)
		leucine-rich repeat	98..121	CDD:275380	3/22 (14%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		leucine-rich repeat	146..169	CDD:275380	4/22 (18%)
		leucine-rich repeat	170..193	CDD:275380	7/22 (32%)
		leucine-rich repeat	194..217	CDD:275380	7/22 (32%)
		leucine-rich repeat	218..265	CDD:275380	14/70 (20%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	10/22 (45%)
		leucine-rich repeat	314..338	CDD:275380	6/23 (26%)
		LRR_8	337..397	CDD:404697	17/86 (20%)
		leucine-rich repeat	339..360	CDD:275380	6/20 (30%)