DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment th and ple

DIOPT Version :9

Sequence 1:	NP_571224.1	Gene:	th / 30384	ZFINID:	ZDB-GENE-990621-5	Length:	489	Species:	Danio rerio
Sequence 2:	NP_001286955.1	Gene:	ple / 38746	FlyBaseID:	FBgn0005626	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	483	Identity:	241/483 - (49%)
Similarity:	332/483 - (68%)	Gaps:	32/483 - (6%)

- Green bases have known domain annotations that are detailed below.

Zfish    20 ELERSDSITSQKFVGRRQ------SLIEDARKEREAAAAA--AEAAGLSEQIVFEESDGKALISL 76
            |.|:|:| .||:..|.:|      .|.||......||:.:  ||||..|..:|....:|   ||
  Fly   111 EQEQSES-QSQEPEGNQQPTKNDYGLTEDEILLANAASESSDAEAAMQSAALVVRLKEG---IS- 170

Zfish    77 FFTLRCSKSPALSRTLKVFETFEAKIHHLETRPSRKPKDGLEDLEYYVQCEVHLSDVSTLVSSLK 141
                      :|.|.||..|||...:.|:|:|.||  .:|: |.:..::.::...::..|:.||:
  Fly   171 ----------SLGRILKAIETFHGTVQHVESRQSR--VEGV-DHDVLIKLDMTRGNLLQLIRSLR 222

Zfish   142 RSAE------DVKTTKEVKFHWFPRKIAELDKCHHLVTKYDPDLDQDHPGFTDPVYRKRRKMIGD 200
            :|..      .......||..|||:..:|||.|:||:|||:||||.:||||.|.|||:|||.|.:
  Fly   223 QSGSFSSMNLMADNNLNVKAPWFPKHASELDNCNHLMTKYEPDLDMNHPGFADKVYRQRRKEIAE 287

Zfish   201 IAFKYRHGEPIPRVDYTEEEIGTWREVYSTLRDLYTTHACSEHLEAFRLLEKHCGYSPDNIPQLE 265
            |||.|::|:|||.:||::.|:.|||.|:.|::||...|||:|:..||:.|:....:....:|||:
  Fly   288 IAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAFQKLQDEQIFVETRLPQLQ 352

Zfish   266 DVSCFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCVHELLGHVPI 330
            ::|.||::.|||.|||.||||:|||||||||||:||.|||:||.:||.|:||||.:||||||:|:
  Fly   353 EMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPYHTPEPDSIHELLGHMPL 417

Zfish   331 LSDRTFAQFSQSIGLASLGASDEDIEKLSTMYWFTVEFGLCKQGGVIKAYGAGLLSSYGELVHSL 395
            |:|.:||||||.|||||||||||:||||||:|||||||||||:.|.|||||||||||||||:|::
  Fly   418 LADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQIKAYGAGLLSSYGELLHAI 482

Zfish   396 SDEPERREFDPDIVAVQPYQDQTYQPVYFVSESFVDATEKLRTYVTRIKRPFSVRFDPYTDSIEV 460
            ||:.|.|.|:|...||||||||.|||:|:|:|||.||.:|.|.:|:.:.|||.|||:|:|:.:||
  Fly   483 SDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVSTMSRPFEVRFNPHTERVEV 547

Zfish   461 LDNPLKIQKGLETIKDELKILTDALNVL 488
            ||:..|::..:..:..|:..||:|::.|
  Fly   548 LDSVDKLETLVHQMNTEILHLTNAISKL 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
th	NP_571224.1	Tyr_3_monoox	36..489	CDD:130336	234/467 (50%)
		ACT	36..151	CDD:298841	33/128 (26%)
		Biopterin_H	157..486	CDD:278766	198/328 (60%)
ple	NP_001286955.1	Tyr_3_monoox	130..576	CDD:130336	233/463 (50%)
		ACT	130..234	CDD:298841	32/120 (27%)
		Biopterin_H	243..573	CDD:278766	198/329 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581373
Domainoid	1	1.000	432	1.000	Domainoid score	I563
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H307
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1578
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	1	1.000	-	-		otm25545
orthoMCL	1	0.900	-	-		OOG6_108343
Panther	1	1.100	-	-	LDO	PTHR11473
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4798
SonicParanoid	1	1.000	-	-		X3954
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790