DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyp26a1 and Cyp6a14

DIOPT Version :9

Sequence 1:	NP_571221.2	Gene:	cyp26a1 / 30381	ZFINID:	ZDB-GENE-990415-44	Length:	492	Species:	Danio rerio
Sequence 2:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	105/498 - (21%)
Similarity:	189/498 - (37%)	Gaps:	126/498 - (25%)

- Green bases have known domain annotations that are detailed below.

Zfish    46 PGTMGLPFIGETLQLI-------LQRRKFLRMKRQKYGCIYKTHLFGNPTVRVMGADNVRQILLG 103
            |....||.:|....::       :.:|.:.:.|.|  |.|...::|...|..:...|.::|:::.
  Fly    32 PHETPLPIVGNMRGIVKKYHFRDINQRIYKKFKGQ--GPIAGMYMFFKRTALITDLDFIKQVMIK 94

Zfish   104 EHK----------------------LVSVQWPASVRTILGSDTLSNVHGVQHKNKKKAIMRAFSR 146
            :..                      |...:|.|....:....|...:     |...|.|:....|
  Fly    95 DFSYFQDRGAFTNPRDDPLTGHLFALEGEEWRAMRHKLTPVFTSGKI-----KQMSKVIVDVGLR 154

Zfish   147 --DALEHYIPVIQQEVKSAIQEWLQKDSCVLVYPEMKKLMFRIAMRIL----LGFEPEQIKTDEQ 205
              ||::           .|::|...::..|    |:|.|..|....::    .|.|...::....
  Fly   155 LGDAMD-----------KAVKEAKVEEGNV----EIKDLCARFTTDVIGSCAFGLECNSLQDPSA 204

Zfish   206 ELVEAFEEMIKNLFSLPIDVPFSGLYRGLRARN--------FIHSKIEENIRKKIQDDD------ 256
            |    |.:..:.:|:              |.|:        |.::::...:|.|:..||
  Fly   205 E----FRQKGREIFT--------------RRRHSTLVQSFIFTNARLARKLRIKVLPDDLTQFFM 251

Zfish   257 ----------NENEQKYKDALQLLIENSRRSDEP------------FSLQAMKEAATELLFGGHE 299
                      .:|..|..|.::.:||......|.            .:|:.|...|......|.|
  Fly   252 STVKNTVDYRLKNGIKRNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFVAGFE 316

Zfish   300 TTASTATSLVMFLGLNTEVVQKVREEVQEKVEMGMYTPGKGLSMELLDQLKYTGCVIKETLRINP 364
            |::||.:..:..|.|..::.|::|||::..:   ....|..|:.::|.|:.|...|:.||||.:|
  Fly   317 TSSSTMSLCLYELALQPDIQQRLREEIESVL---ANVDGGELNYDVLAQMTYLDQVLSETLRKHP 378

Zfish   365 PVPGGFRVALKTFELNGYQIP-------KGWNVIYSICDTHDVADVFPNKDEFQPERFMSKGLED 422
            .:|...|...|     .||||       ||...:..:.:.|...:::|..::|.|.||..:.:::
  Fly   379 LLPHLIRETTK-----DYQIPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKN 438

Zfish   423 GSRFNYIPFGGGSRMCVGKEFAKVLLKIFLVELTQHCNWILSN 465
            .....|:|||.|.|.|:|..|.|:..||.||.|.:...:.:||
  Fly   439 RHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSN 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyp26a1	NP_571221.2	p450	14..487	CDD:299894	105/498 (21%)
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	105/498 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940