DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HAS2 and kkv

DIOPT Version :9

Sequence 1:NP_005319.1 Gene:HAS2 / 3037 HGNCID:4819 Length:552 Species:Homo sapiens
Sequence 2:NP_524233.1 Gene:kkv / 45884 FlyBaseID:FBgn0001311 Length:1615 Species:Drosophila melanogaster


Alignment Length:539 Identity:103/539 - (19%)
Similarity:177/539 - (32%) Gaps:195/539 - (36%)


- Green bases have known domain annotations that are detailed below.


Human    40 DNYYFSFGLYGAFLASHLIIQSLFAFLEHRKMKKSLETPIKLNKTVALCIAAYQEDPDYLRKCLQ 104
            |..|:.|       .:|:.....|...:|.      :..|:.|:.|.|.||...|....:.   |
  Fly   622 DPDYYEF-------ETHIFFDDAFEISDHS------DDDIQCNRFVKLLIATMDEAASEIH---Q 670

Human   105 SVKRL----TYP---GIKVVMVIDGNSEDDLYMMDIFSEVMGRDKSATYIWKNNFHEKGPGETDE 162
            :..||    .||   |.::|..:.|.::...::.|                              
  Fly   671 TTIRLRPPKKYPTPYGGRLVWTLPGKTKFITHLKD------------------------------ 705

Human   163 SHKESSQHVTQLVLSNKSICIMQKWGGKREVMYTAFRALGR-------SVD---------YVQVC 211
              |:..:|             .::|.   :||| .:..||.       |||         |:...
  Fly   706 --KDRIRH-------------RKRWS---QVMY-MYYLLGHRLMELPISVDRKDAIAENTYLLTL 751

Human   212 DSDTMLDPASSVEMVKVLEEDPMVGGVGGDVQILNKYDS-WIS-FLSSVRYWMAFNIERACQSYF 274
            |.|....|.:...:|.:::::..:|...|.:..:..... |.. |..::.:|    :::|.:...
  Fly   752 DGDIDFKPNAVTLLVDLMKKNKNLGAACGRIHPVGSGPMVWYQLFEYAIGHW----LQKATEHMI 812

Human   275 GCVQCISGPLGMYRNSLL----------------HEFVEDWYNQEFMGNQCSFGDDRHLTNRVLS 323
            |||.|..|...::|...|                ..:|:  |:|         |:||.|...:|.
  Fly   813 GCVLCSPGCFSLFRGKALMDDNVMKKYTTRSDEARHYVQ--YDQ---------GEDRWLCTLLLQ 866

Human   324 LGYATKYTARSKCLTETPIEYLRWLNQQTRWSKS---YFREWLYNAMWFHKHH-----LWMTYEA 380
            .||..:|:|.|...|..|..:..:.||:.||..|   ...:.|.:|....|.:     |::.|:.
  Fly   867 RGYRVEYSAASDAYTHCPEGFNEFYNQRRRWVPSTIANIMDLLADAKRTIKINDNISLLYIFYQM 931

Human   381 IITG---FFP---FFLIATVIQLFYRGKIW----------------------NILLFLLTVQ--- 414
            ::.|   ..|   |.::.......:|...|                      ||.||:..|.   
  Fly   932 MLMGGTILGPGTIFLMLVGAFVAAFRIDNWTSFHYNIVPILAFMFICFTCKSNIQLFVAQVLSTA 996

Human   415 ----------------------------LVGLIKSSF-ASCLRGN----IVMVFMSLYSVLYMSS 446
                                        |:.::.|.| |:||...    |....:.|.|:..|..
  Fly   997 YALIMMAVIVGTALQLGEDGIGSPSAIFLISMVGSFFIAACLHPQEFWCITCGLIYLLSIPSMYL 1061

Human   447 LLPAKMFAIATINKAGWGT 465
            ||  .:::|..:|...|||
  Fly  1062 LL--ILYSIINLNVVSWGT 1078

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HAS2NP_005319.1 GT2_HAS 84..361 CDD:133056 63/320 (20%)
kkvNP_524233.1 Chitin_synth_C 583..904 CDD:133033 71/361 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 53 1.000 Domainoid score I11344
eggNOG 1 0.900 - - E1_COG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2067
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
54.800

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