DRSC/TRiP Functional Genomics Resources

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Protein Alignment fzd7a and smo

DIOPT Version :10

Sequence 1:NP_571214.2 Gene:fzd7a / 30369 ZFINID:ZDB-GENE-990415-223 Length:559 Species:Danio rerio
Sequence 2:NP_523443.1 Gene:smo / 33196 FlyBaseID:FBgn0003444 Length:1036 Species:Drosophila melanogaster


Alignment Length:518 Identity:129/518 - (24%)
Similarity:222/518 - (42%) Gaps:104/518 - (20%)


- Green bases have known domain annotations that are detailed below.


Zfish    69 HTNQEDAGLEVHQFYPLVKV-QCSMDLKFFLCSMYAPVCTVL---EQAIPPCRSLCERARQGCEA 129
            ||.:| ...:::.:|.|..| :|...::.|||:::.|.|..:   :....|...:|....:.|..
  Fly   118 HTEKE-LNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCRI 181

Zfish   130 LMNKFGFQWPERLRCEN--FPV-----------HGAGEICVGQNTSDAGSPTSNPTPYVPELITL 181
            |.|...|  |:.|||..  ||.           :|.|: |:....     ||.....|.|     
  Fly   182 LYNTTFF--PKFLRCNETLFPTKCTNGARGMKFNGTGQ-CLSPLV-----PTDTSASYYP----- 233

Zfish   182 QPNLVVRPNQQFTCPLQLKVPTYLKYHFMGEKDCGAPCEPTRPNGLMYFREEEVKFGRL--WVGI 244
                                         |.:.||..|:..     :|..:|..:..:|  |.| 
  Fly   234 -----------------------------GIEGCGVRCKDP-----LYTDDEHRQIHKLIGWAG- 263

Zfish   245 WSILCCVSTLFTVLTYLVDMRRF-RYPERPIIFLSGCYFMVAVAYAAGFF--LEDKVVCIDKFSD 306
              .:|.:|.||.|.|:.:|.:.. :||...:.:::.|:.:..|.:...|.  ..:.:||    ..
  Fly   264 --SICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVC----RK 322

Zfish   307 DGYKTVAQGTKKE--GCTILFMILYFFGMASSIWWVILSLTWFLSAGMKWGH--EAIEANSQYFH 367
            ||....::.|..|  .|.::|:::|:|..|..:|:|.|:..|...|   .||  :.|:....|||
  Fly   323 DGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA---MGHVQDRIDKKGSYFH 384

Zfish   368 LAAWAVPAVKTITILAMGQVDGDMLTGVCYVGIYNVDSLRGFVLAPLFVYLFIGTSFLLAGFVSL 432
            |.||::|.|.|||.:|..:|||:.:.|:|:||..|.....|.:|.||...:.||..|:..|.|.|
  Fly   385 LVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIGGYFITRGMVML 449

Zfish   433 FRIRTIMKH------DGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFREQWEKTW-HM 490
            |.    :||      ..:.:.|:..:::|:||.::|..|...:.|||:..|....::|.::: ..
  Fly   450 FG----LKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQF 510

Zfish   491 QTCKRFAV-----PCPVNNFAPMSPDFTVFMIKYLMTMIVGITSGFWIWSGKTLQSWRRFYKR 548
            ..||..:|     .|.:.|    .|...|..:..|.....||....|.|:..::::|:|:.::
  Fly   511 IICKISSVFEEKSSCRIEN----RPSVGVLQLHLLCLFSSGIVMSTWCWTPSSIETWKRYIRK 569

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fzd7aNP_571214.2 CRD_FZ 41..163 CDD:470581 27/110 (25%)
7tm_GPCRs 228..558 CDD:475119 94/342 (27%)
TM helix 1 238..262 CDD:320374 9/25 (36%)
TM helix 2 271..292 CDD:320374 2/20 (10%)
TM helix 3 322..344 CDD:320374 7/21 (33%)
TM helix 4 365..381 CDD:320374 10/15 (67%)
TM helix 5 403..426 CDD:320374 7/22 (32%)
TM helix 6 457..479 CDD:320374 8/21 (38%)
TM helix 7 508..533 CDD:320374 5/24 (21%)
smoNP_523443.1 CRD_SMO 86..221 CDD:143560 27/106 (25%)
7tmF_SMO_homolog 245..568 CDD:320158 94/345 (27%)
TM helix 1 254..279 CDD:320158 9/27 (33%)
TM helix 2 289..310 CDD:320158 2/20 (10%)
TM helix 3 340..366 CDD:320158 8/25 (32%)
TM helix 4 382..398 CDD:320158 10/15 (67%)
TM helix 5 420..449 CDD:320158 9/28 (32%)
TM helix 6 471..498 CDD:320158 9/26 (35%)
TM helix 7 529..554 CDD:320158 6/28 (21%)

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