Protein Alignment Ube2o and Bruce

DIOPT Version :9

• Sequence 1: XP_221132.5
• Gene: Ube2o / 303689
• RGDID: 1310297
• Length: 1291
• Species: Rattus norvegicus
• Sequence 2: NP_001262460.1
• Gene: Bruce / 41260
• FlyBaseID: FBgn0266717
• Length: 4976
• Species: Drosophila melanogaster
• Alignment Length: 1305
• Identity: 268/1305 - (20%)
• Similarity: 450/1305 - (34%)
• Gaps: 452/1305 - (34%)

  Rat   251 FFDDSYGFYPG------QVLIGPAKIFSSVQWLSGVKPVLSTKSKFRVVVEEVQVVELKVTWITK 309
            ||......:||      .:||| |.|...:::..||:|.:|..:  |.:|.::.:....:|...:
  Fly  3813 FFTRVSACHPGNQENLTSLLIG-AIICKPLRFSHGVRPTISGFT--RQMVLQLLLENEHITVSVR 3874

  Rat   310 SFCP-----------GGTDSVSPPPSVIAQENLGRVKRLGCFDHAQ----------RQLGERCLY 353
            |..|           ||..|.:.....:|..|....:|...  |..          :::.:.|:.
  Fly  3875 SQQPLQRRDTLSAVLGGISSGASTSLPVAAVNNHPARRSSA--HHMLFTVTTSTTCQEIMQNCVS 3937

  Rat   354 VFPAKVEPAKIAWECPEKNCAQGEGS---------MAKKVKRLLKK--------------QVVRI 395
            ||      :.:.::.|....| ||.|         .||..:..::|              :.:.:
  Fly  3938 VF------SNLVYQQPTDQRA-GETSASSSGVSSATAKSSESKMEKSSFLNFNNVEAGSMEFLTV 3995

  Rat   396 MSCTPDAQCSRDHAMEDPDKKGEARAGSEVGSASP---------EEQLDGSASPV---------- 441
            .:    |..::|..::|...:.......|..::|.         :|.|..||:.|
  Fly  3996 GA----AVAAKDKRIKDAKNQAAMNKDKETQTSSTNLASNIFNVDEFLLQSANAVNGNQLVIPEY 4056

  Rat   442 ----------------EMQDEGSEELHETGEPLPPFLLKEGGDEGLHSAEQDADDEAADDTDDTS 490
                            .:|:.|    |....|...|.|          ..|...|:.::.....:
  Fly  4057 SDIVLAGDATISQVLASLQNAG----HSLSTPCISFDL----------VLQQRSDDTSEAKKTKA 4107

  Rat   491 SVTSSASSTTSSQSGSG----------------TGRKKSIPLSIKNLKRKHKRKKNKITRDF--- 536
            :.|....|.....|.||                :|||.::..|        :::|:....|:
  Fly  4108 ACTEPLPSPLQRFSSSGGLSLLAHYLPTVYPEHSGRKTTLVFS--------EKEKSPPLSDWVKL 4164

  Rat   537 KPGDRVAVEVVTTMTSADVMWQDGSVECNIRSNDLFPVHHLDNNEFCPGDFVVDKRVQSCPDPAV 601
            :|.|.:..::      .|.:.:..:....:.|   .|.|.|       ..|.:..|:     ||
  Fly  4165 EPNDEIYEDL------EDTLCEPAAKLATVSS---VPQHSL-------AAFGLFLRL-----PA- 4207

  Rat   602 YGVVQSGDHVGRTCMVKWFKLRPSGDDVELIGEEEDVSVYDIADH-PDFRFR-----------TT 654
            |..|...|.:...|::: ..|..:||     |:..|:....:|.. |...|.           :|
  Fly  4208 YSDVLLRDKMRAQCLLR-LVLGVTGD-----GDGNDIYSLSLAPSLPTLPFEVFRQLLDSVPLST 4266

  Rat   655 D-------IVIRIG-----------------NTEDGALPKEDEPS-----VGQVARVDVSSKVEV 690
            |       :||.:|                 |...||...|..||     .|.:.....:..|
  Fly  4267 DDGVLLRRVVIEVGAMHLVLNCLGIFSHQSHNNRIGAPISEPSPSGTSSGSGTIGNGSGNGSV-- 4329

  Rat   691 VWADNSKTIILPQHLYNIESEIEESDYDSVEGSTSGASSDE-----WE--------DDSDSWETD 742
               ..:||                   ::.|.:|..|:||:     |.        ..:.||..:
  Fly  4330 ---SGTKT-------------------NAPEEATPSATSDDKSHMYWAKGTGFGTGSTTQSWNVE 4372

  Rat   743 NGLV----DDEHPKIEDLAAIL----------PTE---QPAAPEEDKGVVISEEAATAAIQGAVA 790
            ..|:    ::||..:  |..:|          |:|   :......|...|..|  .....|..:.
  Fly  4373 QALLRQKSEEEHVTV--LLLVLASYINPGDCIPSEMCGEDILAYHDVRDVTGE--LPPIFQTLLQ 4433

  Rat   791 MAAPVAGLMEKAGKDGPPKSFRELKEAIKILESLKNMTVEQLL----------TGSPTSPTVEPE 845
            .:..:..|......|......|.:.....||:.|:.:::.::|          :|..|.|.|  |
  Fly  4434 QSCLIPALSSYLRNDSVLDITRHIPLYRAILKLLRALSLSKMLVSLLQPSASGSGDSTPPIV--E 4496

  Rat   846 KPTREKKFLDD-IKKLQENLKKTLD--------NVAIAEEEKME-AVPDTERKEDKPEVQSPVKA 900
            ..|..|..:|. .|:|:.|.|..:.        |:...::|.:. .:||..
  Fly  4497 LLTSMKTCVDTYAKRLKVNKKSNIKGQTHQLTFNIDDGDDEGLALLIPDIH-------------- 4547

  Rat   901 EWPSETPVLCQQ---CGGRPGVTFTSAKG------------------------EVFSVLEFAPSN 938
                ||.||.|:   ......:..|:..|                        :.|.::..:.:|
  Fly  4548 ----ETSVLVQKTTDADALINMLHTNEDGSAQLEPQSKSIEQRYLELMKKRQFDTFDMIVESDNN 4608

  Rat   939 -------HSFKKI------EFQPPEAKKFFSTVRKEMALLATSLP----DGIMVKTFEDRMDLFS 986
                   |.|:|:      .:.|...|:    :.:|...|:||||    ..:.|:...||:|:..
  Fly  4609 SFRFVVSHHFEKMVRLAGDRYHPSRVKR----LAQEAVTLSTSLPLSFSSSVFVRCDTDRLDIMK 4669

  Rat   987 ALIKGPTRTPYEDGLYLFDIQLPNIYPAVPP--HFCYLSQCSGRLNPNLYDNGKVCVSLLGTWIG 1049
            .||.||..|||.:|.:.||:..|..||..|.  :.....:.|.|.|||||::||||:|:|.||.|
  Fly  4670 VLITGPADTPYANGCFEFDVFFPPDYPNQPMLINLETTGRHSVRFNPNLYNDGKVCLSVLNTWHG 4734

  Rat  1050 KGTERWTSK-SSLLQVLISIQGLILVNEPYYNEAGFDSDRGLQEGYENSRCYNE---MALIRVVQ 1110
            :..|:|.:: ||.||||:|||.||||.|||:||.||:..||...|..:||.||.   .|.:|  .
  Fly  4735 RPEEKWNAQTSSFLQVLVSIQSLILVPEPYFNEPGFERSRGSPSGTNSSREYNSNIYQACVR--W 4797

  Rat  1111 SMTQLVRRPPEVFEQEIRQHFSVGGWRLVNRIESWLE-----------------THVVLER---- 1154
            :|.:.:|.|.:.|:..|.:||.:....:..:||.|:|                 ..:||.|
  Fly  4798 AMLEQIRSPSQCFKDVIHKHFWLKREEICAQIEGWIEELGKPQYTERASRTISFNSMVLRRHYRH 4862

  Rat  1155 -AQAL-----PNGV--------------PKDSSSLEPQAAAELSDSGREEPEDVGMTP----GEA 1195
             .:.|     |.|:              |.|.|::.|..||  :::.:.:|:|..:|.    ||.
  Fly  4863 LREELSKLKPPRGLEDLDAPFNPVATLPPMDVSAVAPSLAA--TNTVQAQPDDAIVTDITLLGEN 4925

  Rat  1196 SQGSDSEGGAQGPASASREHPEQTETAPDASAPPSVRPKRRRKSYRSFLPEKSGYPDIGFPLFPL 1260
            :...:::|.|:|                                        .|..|.||..||.
  Fly  4926 ADECEADGDAEG----------------------------------------DGEVDDGFKGFPQ 4950

  Rat  1261 SKGFI 1265
            .:|.:
  Fly  4951 EEGLL 4955

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube2o	XP_221132.5	UBCc	958..1108	CDD:238117	70/159 (44%)
Bruce	NP_001262460.1	BIR	251..321	CDD:279047
		DUF3643	3539..3664	CDD:289152
		UQ_con	4636..4790	CDD:278603	69/157 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0895
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810