Protein Alignment fzd5 and fz

DIOPT Version :9

• Sequence 1: NP_571209.2
• Gene: fzd5 / 30364
• ZFINID: ZDB-GENE-990415-218
• Length: 592
• Species: Danio rerio
• Sequence 2: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Alignment Length: 582
• Identity: 241/582 - (41%)
• Similarity: 332/582 - (57%)
• Gaps: 60/582 - (10%)

Zfish    45 CEPITVPMCKGIGYNHTYMPNQFNHDNQDEVGLEVHQFWPLVRIHCSPDLLFFLCSMYTPICLQD 109
            |||||:.:||.|.||.|.|||...|..|:|.|||||||.|||:|.||.||..||||:|.|:| ..
  Fly    53 CEPITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVC-TI 116

Zfish   110 YKKPLPPCRSVCERAKRGCSPLMIQYGFEWPERMSCEQLPMLGDTDRLCMDRN--SSETTTLSPP 172
            .::|:|||||:||.| |.|..||..|.|.|||.:.|.:.|:.|..| ||:..|  ||.:|..:|
  Fly   117 LERPIPPCRSLCESA-RVCEKLMKTYNFNWPENLECSKFPVHGGED-LCVAENTTSSASTAATP- 178

Zfish   173 FPKPTPKGTPRHRATAKSAPPQKCDRECHCRGPLVPIKKEAHPL----HNRVNTGSLPNCALPCH 233
             .:...|.|.|...|...:|.:.....|       |::.:. ||    ..:|....|.:|..|||
  Fly   179 -TRSVAKVTTRKHQTGVESPHRNIGFVC-------PVQLKT-PLGMGYELKVGGKDLHDCGAPCH 234

Zfish   234 QPYFSQDERTFTTFWIGLWSVLCFVSTFTTVATFLIDMERFKYPERPIIFLAACYLFVSLGYIVR 298
            ..:|.:.|||...:|:|.|:.:|..|...||.|||||..||:||||.|:|||.|||.|...|:..
  Fly   235 AMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAG 299

Zfish   299 LLAGHERVACE---------------GTGDQQHILYDTTGPALCTLVFLLIYFFGMASSIWWVVL 348
            |.|| :.|:|.               .|..|.|  ..||.   ||::|:.:||..||:..||..|
  Fly   300 LGAG-DSVSCREPFPPPVKLGRLQMMSTITQGH--RQTTS---CTVLFMALYFCCMAAFAWWSCL 358

Zfish   349 SFTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLEGLR 413
            :|.||||||:|||:|||...|..|||.||.||::::|:||||:.|:||.::|:|:||......|.
  Fly   359 AFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLG 423

Zfish   414 GFVLAPLVVYLFTGSLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGLFTVLYTVPATIVVA 478
            .|::.||.:||..|:|||||||:||||||:|:|..|.:|||||:||:|||.|:.|:.:||..::.
  Fly   424 AFLILPLCIYLSIGALFLLAGFISLFRIRTVMKTDGKRTDKLERLMLRIGFFSGLFILPAVGLLG 488

Zfish   479 CLVYEQH----YRPSWERAL----ACSCPSERQRLGMG-----PDYAVFMLKYFMCLVVGITSGV 530
            ||.||.:    :...|.|.:    :..||:.|   ..|     |.:.:||:||...::||:||.|
  Fly   489 CLFYEYYNFDEWMIQWHRDICKPFSIPCPAAR---APGSPEARPIFQIFMVKYLCSMLVGVTSSV 550

Zfish   531 WIWSGKTLESWRRFIARYVPCRTRKPPVSASSMYSEASTALTARAGTAPTGTYHKSAPSSHV 592
            |::|.||:.|||.|:.|.    ..|.|.:.:..|....|.....|.:.|.....::|..|::
  Fly   551 WLYSSKTMVSWRNFVERL----QGKEPRTRAQAYVXYETGPAGGAKSTPLTPDPEAANESYL 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fzd5	NP_571209.2	CRD_FZ5_like	44..163	CDD:143565	64/119 (54%)
		7tmF_FZD5	235..546	CDD:320377	149/338 (44%)
		TM helix 1	244..269	CDD:320377	9/24 (38%)
		TM helix 2	278..299	CDD:320377	11/20 (55%)
		TM helix 3	328..354	CDD:320377	11/25 (44%)
		TM helix 4	371..387	CDD:320377	8/15 (53%)
		TM helix 5	409..438	CDD:320377	14/28 (50%)
		TM helix 6	458..485	CDD:320377	13/26 (50%)
		TM helix 7	507..532	CDD:320377	11/29 (38%)
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	63/116 (54%)
		Frizzled	237..564	CDD:279827	148/335 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810