DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzd5 and smo

DIOPT Version :9

Sequence 1:	NP_571209.2	Gene:	fzd5 / 30364	ZFINID:	ZDB-GENE-990415-218	Length:	592	Species:	Danio rerio
Sequence 2:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	131/507 - (25%)
Similarity:	220/507 - (43%)	Gaps:	88/507 - (17%)

- Green bases have known domain annotations that are detailed below.

Zfish    72 QDEVGLEVHQFWPLVRI-HCSPDLLFFLCSMYTPIC----------LQDYKKPLPPCRSVCERAK 125
            :.|:..:::.::.|..: .|...:..|||:::.|.|          |..|:.    ||...|
  Fly   120 EKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEM----CRITME--- 177

Zfish   126 RGCSPLMIQYGFE-WPERMSCEQLPMLGDTDRLCMDRNSSETTTLSPPFPKPTPKGTPRHRATAK 189
                |..|.|... :|:.:.|.:                    ||   ||.....|
  Fly   178 ----PCRILYNTTFFPKFLRCNE--------------------TL---FPTKCTNG--------- 206

Zfish   190 SAPPQKCDRECHCRGPLVPIKKEA--HPLHNRVNTGSLPNCALPCHQPYFSQDERTFTTFWIGLW 252
             |...|.:....|..||||....|  :|        .:..|.:.|..|.::.||.......||..
  Fly   207 -ARGMKFNGTGQCLSPLVPTDTSASYYP--------GIEGCGVRCKDPLYTDDEHRQIHKLIGWA 262

Zfish   253 SVLCFVSTFTTVATFLIDMERF-KYPERPIIFLAACYLFVSLGYIVRLLAG-HERVACEGTGDQQ 315
            ..:|.:|....|:||.||.:.. |||...:.::..|:|...:|::::..:| .|.:.|...|..:
  Fly   263 GSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCRKDGTLR 327

Zfish   316 HILYDTTGPAL-CTLVFLLIYFFGMASSIWWVVLSFTWFLAAGMKWGNEAIAGYSQYFHLAAWLV 379
            | ...|.|..| |.::|:|:|:|..|..:|:|.|::.|...| |....:.|.....||||.||.:
  Fly   328 H-SEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA-MGHVQDRIDKKGSYFHLVAWSL 390

Zfish   380 PSVKSIAVLALSSVDGDPVAGICYVG--NQSLEGLRGFVLAPLVVYLFTGSLFLLAGFVSLFRIR 442
            |.|.:|..:|.|.|||:.:.|||:||  |.|:..  |.:|.||...:..|..|:..|.|.||.::
  Fly   391 PLVLTITTMAFSEVDGNSIVGICFVGYINHSMRA--GLLLGPLCGVILIGGYFITRGMVMLFGLK 453

Zfish   443 SVIK--QGGTKTDKLEKLMIRIGLFTVLYTVPATIVVACLVYEQHYRPSWERA----LACSCPS- 500
            ....  :..:.::|:..:::|:|:..:|..|...:.:||.|.|..:...|.::    :.|...|
  Fly   454 HFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEWAQSFRQFIICKISSV 518

Zfish   501 --ERQ--RLGMGPDYAVFMLKYFMCLV-VGITSGVWIWSGKTLESWRRFIAR 547
              |:.  |:...|...|..| :.:||. .||....|.|:..::|:|:|:|.:
  Fly   519 FEEKSSCRIENRPSVGVLQL-HLLCLFSSGIVMSTWCWTPSSIETWKRYIRK 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzd5	NP_571209.2	CRD_FZ5_like	44..163	CDD:143565	18/102 (18%)
		7tmF_FZD5	235..546	CDD:320377	96/327 (29%)
		TM helix 1	244..269	CDD:320377	7/24 (29%)
		TM helix 2	278..299	CDD:320377	3/20 (15%)
		TM helix 3	328..354	CDD:320377	9/25 (36%)
		TM helix 4	371..387	CDD:320377	9/15 (60%)
		TM helix 5	409..438	CDD:320377	8/28 (29%)
		TM helix 6	458..485	CDD:320377	8/26 (31%)
		TM helix 7	507..532	CDD:320377	7/25 (28%)
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	26/144 (18%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	95/326 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820