Protein Alignment fzd4 and fz2

DIOPT Version :9

• Sequence 1: NP_001292398.1
• Gene: fzd4 / 30363
• ZFINID: ZDB-GENE-990415-217
• Length: 523
• Species: Danio rerio
• Sequence 2: NP_001262037.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 806
• Species: Drosophila melanogaster
• Alignment Length: 584
• Identity: 230/584 - (39%)
• Similarity: 317/584 - (54%)
• Gaps: 117/584 - (20%)

Zfish    24 EEEMTCDPIRISMCQDLGYNVTKMPNLVGNVLQSDAELQLTTFTPLIQYGCSSQLKFFLCSVYVP 88
            :..:.|:.|.|.||:.:|||:|..||.:.:..|.:|.|::..|.||::..||..|||||||:|.|
  Fly    59 DPNLRCEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTP 123

Zfish    89 MCTEKVPIPIGPCGSMCMSVKRKCLPVLQEFGFVWPELLNCSLFPPTNDQNHMCMEGP------- 146
            :|.|....|:..|.|:|...:..|.|::|::.|.|||.:.|...|...|.:::|||.|
  Fly   124 ICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGS 188

Zfish   147 ---------------------------------GDEDPPFHAVRPVA---------PQEE----- 164
                                             |.....  :.:|..         ||.|
  Fly   189 GGSSGGSGGSGSGSGSGGKRKQGGSGSGGSGAGGSSGST--STKPCRGRNSKNCQNPQGEKASGK 251

Zfish   165 ECIA------LGAGVEQ--------------YAW-----VKRSG---SCSLQCGYDTGLYRRQAK 201
            ||..      :..|.||              :.|     |:|..   :|.:.|  ....:....|
  Fly   252 ECSCSCRSPLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPC--KGPFFSNDEK 314

Zfish   202 VFTDVWMAVWAVLCFISTTFTVLTFLVDSSRFSYPERPIIFLSMCCNIYSVAFIVRLTVGRERIS 266
            .|..:|:|:|:.|||.||..|:.||::|:.||.||||||:|||.|..:.:|.::.|..:..|.|:
  Fly   315 DFAGLWIALWSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIA 379

Zfish   267 CDLEEAAVPVLVQEGLKNTG---CAIVFLLTYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMH 328
            ||      .:|::|  .:||   |.:|||||||||||||||||||:.|||||||||||:|||..|
  Fly   380 CD------GLLLRE--SSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKH 436

Zfish   329 SSYFHIAAWAIPAVKTIVILIMRLVDADDLAGMCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAA 393
            |.|||:|||.||.|:::.:|::..||.|.:.|:|||||.|.|.|..||:||||.||||||.|:.|
  Fly   437 SQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMA 501

Zfish   394 GLVALFKIRSNLQKD-----GTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYE---ISNW--- 447
            |.|:||:|||.:::.     |.|.||||:||::||:||||||||||.||.||.||   ..:|
  Fly   502 GFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIKA 566

Zfish   448 -----ADFRQTARDSYMAAEMLRIFMSLLVGITSGMWVWSAKTLHTWQRCSHRLV----HTGRN 502
                 |..:...:....:..||:.||:|.||||||:|:||.|||.:|:|...||:    .||.|
  Fly   567 LACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGAPDRTGAN 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fzd4	NP_001292398.1	CRD_FZ4	26..150	CDD:143557	49/163 (30%)
		Frizzled	195..492	CDD:279827	161/315 (51%)
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	47/118 (40%)
		Frizzled	308..618	CDD:279827	162/317 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920