DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzd4 and smo

DIOPT Version :9

Sequence 1:	NP_001292398.1	Gene:	fzd4 / 30363	ZFINID:	ZDB-GENE-990415-217	Length:	523	Species:	Danio rerio
Sequence 2:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster

Alignment Length:	496	Identity:	134/496 - (27%)
Similarity:	217/496 - (43%)	Gaps:	96/496 - (19%)

- Green bases have known domain annotations that are detailed below.

Zfish    74 CSSQLKFFLCSVYVPMCTEKV---PIPIGPCGSMCMSVKRKCLPVLQEFGFVWPELLNC--SLFP 133
            |.:.::.|||:|:.|.| ||:   .:...|...||......| .:|....| :|:.|.|  :|||
  Fly   139 CWAAIQPFLCAVFKPKC-EKINGEDMVYLPSYEMCRITMEPC-RILYNTTF-FPKFLRCNETLFP 200

Zfish   134 P--TNDQNHMCMEGPGDEDPPFHAVRPVAPQEEECIALGAGVEQYAWVKRSGSCSLQCG---YDT 193
            .  ||....|...|.|      ..:.|:.|.:... :...|:|         .|.::|.   |..
  Fly   201 TKCTNGARGMKFNGTG------QCLSPLVPTDTSA-SYYPGIE---------GCGVRCKDPLYTD 249

Zfish   194 GLYRRQAKVFTDVWMAVWA-VLCFISTTFTVLTFLVD-SSRFSYPERPIIFLSMCCNIYSVAFIV 256
            ..:|:..|:..      || .:|.:|..|.|.||.:| .:...||...:.::::|..|..|.:::
  Fly   250 DEHRQIHKLIG------WAGSICLLSNLFVVSTFFIDWKNANKYPAVIVFYINLCFLIACVGWLL 308

Zfish   257 RLTVG-RERISCDLEEAAVPVLVQEGL---------KNTGCAIVFLLTYFFGMASSIWWVILTLT 311
            :.|.| ||.|.|.          ::|.         :|..|.::|:|.|:|..|..:|:|.||..
  Fly   309 QFTSGSREDIVCR----------KDGTLRHSEPTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYA 363

Zfish   312 WFLAAGLKWGH--EAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADDLAGMCYVGNQNLDALTG 374
            |...|   .||  :.|:...||||:.||::|.|.||..:....||.:.:.|:|:||..|.....|
  Fly   364 WHWRA---MGHVQDRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAG 425

Zfish   375 FVVAPLFTYLVIGTLFIAAGLVALFKIR--SNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVI 437
            .::.||...::||..||..|:|.||.::  :|..|..:.::|:..:::::||.::|..|.....|
  Fly   426 LLLGPLCGVILIGGYFITRGMVMLFGLKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAI 490

Zfish   438 ACY---FYEISNWA-DFRQ------------------TARDS--YMAAEMLRIFMSLLVGITSGM 478
            ||:   |.....|| .|||                  ..|.|  .:...:|.:|.|   ||....
  Fly   491 ACHVTEFRHADEWAQSFRQFIICKISSVFEEKSSCRIENRPSVGVLQLHLLCLFSS---GIVMST 552

Zfish   479 WVWSAKTLHTWQR-----CSHRLVHTGRNNRVKRTANGWVK 514
            |.|:..::.||:|     |...:|...:..:.|..|..|.|
  Fly   553 WCWTPSSIETWKRYIRKKCGKEVVEEVKMPKHKVIAQTWAK 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzd4	NP_001292398.1	CRD_FZ4	26..150	CDD:143557	26/82 (32%)
fzd4	NP_001292398.1	Frizzled	195..492	CDD:279827	95/341 (28%)
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	26/90 (29%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	96/343 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920