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Protein Alignment HARS1 and HisRS

DIOPT Version :9

Sequence 1:	NP_002100.2	Gene:	HARS1 / 3035	HGNCID:	4816	Length:	509	Species:	Homo sapiens
Sequence 2:	NP_573305.2	Gene:	HisRS / 32841	FlyBaseID:	FBgn0027087	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	327/555 - (58%)
Similarity:	396/555 - (71%)	Gaps:	57/555 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     4 RAALEELVKLQGERVRGLKQQKASAE--------------------------------------- 29
            |..:.|.:|:||:.||.||..|.|.|
  Fly     5 REQILEQIKVQGDLVRQLKAAKESKEKTAPSGGGRVSSSGVPAQRQQQQQPQKQQQAQVQQQQHE 69

Human    30 ---LIEEEVAKLLKLKAQLGPD--ESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGA 89
               .|:||||:||.|||.||.|  .:.|||.||||||||||.|:||.:|:.|.|.|::.|||||.
  Fly    70 QLHQIDEEVARLLALKATLGGDAAPTNQKFTLKTPKGTRDYGPQQMTLRQGVLDKIVQVFKRHGG 134

Human    90 EVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAK 154
            |.||||||||||.|.|||||||||||||||||||:||:|||||||.||||||||:::||||||||
  Fly   135 EAIDTPVFELKEVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNKISSIKRYHIAK 199

Human   155 VYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDG 219
            ||||||||||:|||||||||||||||.:|||:|||||:||:.|||.:|.|||:::|:|.|::|||
  Fly   200 VYRRDNPAMTKGRYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIKLNHRQLLDG 264

Human   220 MFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLL 284
            ||..|||....||||||:||||||..|.:|:.|||.||||....|||||:||:..||..||||||
  Fly   265 MFQACGVPADSFRTICSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRLSGGAELVEQLL 329

Human   285 QDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVL--------- 340
            .:.||.....|::||..:|.|.:|.::||:|.::|||||||||||||||||||.||
  Fly   330 ANEKLKAVPNAVKGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEGVLKGESATVAS 394

Human   341 -LQTPAQAGE---EPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALE 401
             .:|..|.||   ||..|||||.|||||.|||||||:|:.|||||:|||||||||::|.|..|..
  Fly   395 PAKTSQQNGEQANEPATVGSVAGGGRYDNLVGMFDPRGKAVPCVGVSIGVERIFSVLEARAAASG 459

Human   402 EKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAII 466
            .|:||::.:|.||||.|.|.|:|||:::.|||||:|||..||.|||||.|||:|||..||||.::
  Fly   460 LKLRTSDVEVYVASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHCEEHQIPLVVVL 524

Human   467 GEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRR 501
            |:.||..|::|||.||:|||.:|:.|||..||:||
  Fly   525 GDAELAQGLVKLREVTTREETNVKLEDLAAEIRRR 559

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.