DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rnf43 and gzl

DIOPT Version :9

Sequence 1:	XP_006247152.1	Gene:	Rnf43 / 303412	RGDID:	1305204	Length:	802	Species:	Rattus norvegicus
Sequence 2:	NP_001097695.1	Gene:	gzl / 40791	FlyBaseID:	FBgn0037442	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	121/536 - (22%)
Similarity:	188/536 - (35%)	Gaps:	158/536 - (29%)

- Green bases have known domain annotations that are detailed below.

  Rat    27 HTGLVLAAAVESERSAEQKAI--IRVIPLKMDPTGKLNLTLEGVFAGVAEVSPAEGKLMQSHPLY 89
            |...::...|...|.|..:.|  ...:|.:..|    ||...|:   ...|.||.      .|.|
  Fly    19 HEATLVGGHVLVYRKATSQLIEEFNDLPAQFGP----NLPSNGL---KVYVVPAR------RPYY 70

  Rat    90 LCNASDDD---NLEPG--FISIVKLESPRRAPRPCLSLASKARMAGERGASAVLFDITE----DR 145
            .|::.|..   ...|.  |:::|       |...|: ...|.|:|.....|||:....|    ::
  Fly    71 GCDSLDRPPHLKYPPSAKFVALV-------ARGECV-FERKIRVAQNASYSAVIVYNNEGDDLEQ 127

  Rat   146 SAAEQLQQPLGLTKPVVLIWGSDAEKLMEFVYKNRKAYVWIELKEPPAWANYDVWILL---TVVG 207
            .:||.:   .|:..|.|.:..:..:.|.  .|...:..:.|..:.|   .|.:..::|   .::|
  Fly   128 MSAENI---TGIRIPSVFVGHTTGKALA--TYFTTEVVLIINDELP---FNINTQLILPFSILIG 184

  Rat   208 TVFVIILASVLRIRCRPHPSRPDPLQQRTAR-------AISQLATRRYQASCRRARAEWPDSGSS 265
            ..|:|::..::....|         :||..|       .:.:|...||            ...::
  Fly   185 MCFIIMVIYMIYKCIR---------EQRRLRRHRLPKSMLKKLPVLRY------------TKNNA 228

  Rat   266 SSSAPVCAICLEEFTEGQELRVISCLHEFHRTCVDPWLHQH-RTCPLC----------------- 312
            ::....|.||||:|.|..:|||:.|.|.:|..|:||||.:: |.||:|
  Fly   229 NNKYDTCVICLEDFIEDDKLRVLPCSHPYHTHCIDPWLTENRRVCPICKRKVFTKGEARASRSRQ 293

  Rat   313 --MFNIVEGDSFSQALGASPSYQEPGRRLHLIRQHPGHAHYHLPSAYLLGPSRNS--------VA 367
              :.|:.:.|.     ..:|..|:        :|..|.....:.||...|.:..|        ||
  Fly   294 PSLDNVTDTDD-----DTTPLLQQ--------QQSNGRQVGQVSSASSAGGAAGSSSSVAAAAVA 345

  Rat   368 QTPR----------PRPFLPSQ-------------EPSMGS-RHQRLPRASHLRAPEEQQHLAVS 408
            .|.|          ..||..||             .|:..| .|:|:....  |||....|||..
  Fly   346 GTTRHGTFRRGHAGRNPFEESQSSDDENALLASTVRPATSSGAHERINPFD--RAPNLPAHLAEQ 408

  Rat   409 PGHPYAQGWGPNRLRCTS---QHPNACPVALRRARPH-ESSGSGESYCTERSGYLADG------P 463
            ........|  :|:...|   :.|....||   |.|: |...||    |...|....|      |
  Fly   409 LTESRRSVW--SRINFASFFRRQPAVISVA---APPYLERVESG----TSAMGLPVTGTIAVASP 464

  Rat   464 ASDSSSGP-CHGSSSD 478
            ||::...| ..||..|
  Fly   465 ASNNILNPNLSGSFKD 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf43	XP_006247152.1	ZNRF_3_ecto	85..187	CDD:408039	23/110 (21%)
		RING-H2_RNF43	270..316	CDD:319712	22/65 (34%)
		dnaA	598..>743	CDD:237605
gzl	NP_001097695.1	PA_C_RZF_like	14..171	CDD:239038	38/180 (21%)
gzl	NP_001097695.1	zf-RING_2	233..277	CDD:290367	21/43 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920