DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rnf43 and Rnf43

DIOPT Version :9

Sequence 1:	XP_006247152.1	Gene:	Rnf43 / 303412	RGDID:	1305204	Length:	802	Species:	Rattus norvegicus
Sequence 2:	NP_766036.2	Gene:	Rnf43 / 207742	MGIID:	2442609	Length:	784	Species:	Mus musculus

Alignment Length:	792	Identity:	719/792 - (90%)
Similarity:	740/792 - (93%)	Gaps:	12/792 - (1%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MSGGHQLQLAVLWPWLLMATLHAGFGHTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGKLNLTL 65
            |||||||||||||||||||||||||||||.||||||||||||||||:||||||||||||||||||
Mouse     1 MSGGHQLQLAVLWPWLLMATLHAGFGHTGRVLAAAVESERSAEQKAVIRVIPLKMDPTGKLNLTL 65

  Rat    66 EGVFAGVAEVSPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAG 130
            ||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 EGVFAGVAEVTPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAG 130

  Rat   131 ERGASAVLFDITEDRSAAEQLQQPLGLTKPVVLIWGSDAEKLMEFVYKNRKAYVWIELKEPPAWA 195
            ||||:||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||.|
Mouse   131 ERGANAVLFDITEDRSAAEQLQQPLGLTKPVVLIWGSDAAKLMEFVYKNRKAYVWIELKEPPAGA 195

  Rat   196 NYDVWILLTVVGTVFVIILASVLRIRCRPHPSRPDPLQQRTARAISQLATRRYQASCRRARAEWP 260
            ||||||||||||||||||||||||||||||.||||||||||||||||||||||||.|||||||||
Mouse   196 NYDVWILLTVVGTVFVIILASVLRIRCRPHHSRPDPLQQRTARAISQLATRRYQAGCRRARAEWP 260

  Rat   261 DSGSSSSSAPVCAICLEEFTEGQELRVISCLHEFHRTCVDPWLHQHRTCPLCMFNIVEGDSFSQA 325
            |||||.||.||||||||||:|||||||||||||||||||||||:|||||||||||||||||||||
Mouse   261 DSGSSCSSTPVCAICLEEFSEGQELRVISCLHEFHRTCVDPWLYQHRTCPLCMFNIVEGDSFSQA 325

  Rat   326 LGASPSYQEPGRRLHLIRQHPGHAHYHLPSAYLLGPSRNSVAQTPRPRPFLPSQEPSMGSRHQRL 390
            ..||||||||||||||||||||||||||||||||||||.|||:||||||||||||||||||||||
Mouse   326 PAASPSYQEPGRRLHLIRQHPGHAHYHLPSAYLLGPSRTSVARTPRPRPFLPSQEPSMGSRHQRL 390

  Rat   391 PRASHLRAPEEQQHLAVSPGHPYAQGWGPNRLRCTSQHPNACPVALRRARPHESSGSGESYCTER 455
            ||.|||||||||||||||| ||||||||.||||||||||.|||||||||||||||||||||||||
Mouse   391 PRTSHLRAPEEQQHLAVSP-HPYAQGWGLNRLRCTSQHPAACPVALRRARPHESSGSGESYCTER 454

  Rat   456 SGYLADGPASDSSSGPCHGSSSDSVVNCTDISLQGVHGSSSTFRSSLSSDFDPLVYCSPEGALQG 520
            ||||||||||||||||||||||||||||||:||||:|||||||||||||||||||||||||.|||
Mouse   455 SGYLADGPASDSSSGPCHGSSSDSVVNCTDVSLQGIHGSSSTFRSSLSSDFDPLVYCSPEGDLQG 519

  Rat   521 KEVQPSMTSRPRSLDSVVPTGETQVSSHIHYHRHRHHHYKKQFQWHSRKPGLETGVPQSRPAASH 585
            |.:|||:||||||||||||.||||||||||||||||||||:|||||.||||.|||:|||.|||||
Mouse   520 KGIQPSVTSRPRSLDSVVPRGETQVSSHIHYHRHRHHHYKRQFQWHGRKPGPETGIPQSMPAASH 584

  Rat   586 TQLEPSLPDQQLTTPNPAVSSMLPNPQRPRALTEPAPGLAEAVSPSPSPNPS---LLNLQKSNLP 647
            ||||||||||||.||||..|||||||||||||||||||||||.||||||.|:   |||||||:|.
Mouse   585 TQLEPSLPDQQLITPNPTASSMLPNPQRPRALTEPAPGLAEASSPSPSPKPNPSGLLNLQKSSLT 649

  Rat   648 VRYPQRKRRGGPSEALPTSQPQDLTVHTACPVPPHYSPSLAYPWPPEVHPLIFRPPGLDRRLLHD 712
            ||:|.|||||||||.||||.|.||||||||||.|||||.||||||||||||:|||||.||||||:
Mouse   650 VRHPHRKRRGGPSEPLPTSLPPDLTVHTACPVFPHYSPRLAYPWPPEVHPLMFRPPGPDRRLLHE 714

  Rat   713 VPGPCYSSSQPVWLYLNPRQPLGPCLPGEGHSKWSFDTPEDRRCPYSHCQVLPAQPGECSGKQVF 777
            ||||||||||||||||||.|||||||||||||||:||:||.||||||||||||||||.
Mouse   715 VPGPCYSSSQPVWLYLNPCQPLGPCLPGEGHSKWTFDSPEGRRCPYSHCQVLPAQPGS------- 772

  Rat   778 WEKETISGCWRA 789
             |:|....|.:|
Mouse   773 -EEELEELCEQA 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf43	XP_006247152.1	ZNRF_3_ecto	85..187	CDD:408039	99/101 (98%)
		RING-H2_RNF43	270..316	CDD:319712	43/45 (96%)
		dnaA	598..>743	CDD:237605	125/147 (85%)
Rnf43	NP_766036.2	zf-RING_2	270..312	CDD:290367	39/41 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..407		39/42 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..478		18/18 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..671		131/157 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C55137539
Domainoid	1	1.000	903	1.000	Domainoid score	I2621
eggNOG	1	0.900	-	-		E33208_3BFF8
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37742
Inparanoid	1	1.050	1509	1.000	Inparanoid score	I3307
OMA	1	1.010	-	-		QHG38388
OrthoDB	1	1.010	-	-		D109650at7742
OrthoFinder	1	1.000	-	-		FOG0013512
OrthoInspector	1	1.000	-	-		oto179464
orthoMCL	1	0.900	-	-		OOG6_118517
Panther	1	1.100	-	-	LDO	PTHR16200
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770