DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rnf43 and plr-1

DIOPT Version :9

Sequence 1:	XP_006247152.1	Gene:	Rnf43 / 303412	RGDID:	1305204	Length:	802	Species:	Rattus norvegicus
Sequence 2:	NP_499473.2	Gene:	plr-1 / 176575	WormBaseID:	WBGene00023404	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	559	Identity:	132/559 - (23%)
Similarity:	205/559 - (36%)	Gaps:	169/559 - (30%)

- Green bases have known domain annotations that are detailed below.

  Rat     6 QLQLAVLWPWLLMAT--LHA--GFGHTGL-------------VLAAAVESERSAEQKAIIRVIPL 53
            :|.|.:|....|::|  :||  ...||.|             |....:..:|:.::|.|
Worm     2 RLLLFILLNTTLLSTNYVHARPSVSHTTLASQFKFAEKADIFVTHTNINEDRTQDEKTI------ 60

  Rat    54 KMDPTGKLNLTLEGVFAGVAEVSPAEGKLMQSHPLYLCNASDD--DNLEPGFISIVKLESPRRAP 116
                      .|.|.|:.|.......|.::|......|:|...  ||.....:.:|..:...:..
Worm    61 ----------KLSGTFSPVGSNYETGGDIVQVSSFRACDARRKGLDNTVFEHVPVVFYDDVEKFL 115

  Rat   117 RPCLSLASKARMAGERGASAVLFDITEDRSAAEQLQQPL---GLTKPVVLIWGSDAEKL------ 172
            ..|::|.::||.|.:.||.|:   |....|..|:..:|:   |...||:::.....|:|
Worm   116 TGCVALDNQARFAEKSGAMAL---IVGPASRVERTTRPMMIGGSKIPVIVLDDEQTERLRSELRS 177

  Rat   173 -----------MEFVYKNRKAYVWIELKEPPAWANYDVWILLTVVGTVFVII----LASVLRIRC 222
                       :.|:.:.....:.:::..|..       :.:|::|.:.::|    |..|::|||
Worm   178 ASERGAVTKLRISFIDEKPTKVLKLQVFRPTV-------LNITLLGLLIILIVFVSLLVVVKIRC 235

  Rat   223 RPHPSRPDPLQQRTARAISQLATRRYQ------------ASCRRARAEWPDSGSSSSSAPV---- 271
            :|...|...|:.....|::::..|.:|            .|...||.:...|.||..|:.:
Worm   236 QPTMHRELWLRALARTALTKMEIRSFQKEKNVEAGQKKKTSSTFARLKQHRSSSSRHSSYLAVFG 300

  Rat   272 ----------------CAICLEEFTEGQELRVISCLHEFHRTCVDPWLHQHRTCPLCMFNIVEGD 320
                            |.|||||:.||.||||:.|.||||..||||||...|.||||.|::|
Worm   301 SLTSVAQSSSHSAQERCVICLEEYEEGTELRVLFCGHEFHPKCVDPWLLSKRRCPLCQFDVV--- 362

  Rat   321 SFSQALGASPSYQEPGRRLHLIRQHPGHAHYHLPSA----YLLGPSRNSVAQTPRPRPF--LPSQ 379
                                         :.|.|..    .|.|.|.::.:..||..|.  |||.
Worm   363 -----------------------------YKHYPKVDSPEKLSGRSDDTTSLLPRTSPSEDLPSA 398

  Rat   380 EPSMGSRHQRLPRASHLRAPEEQQHLAVSPGHPYAQGWGPNRLRCTSQHPNACPVALR-RARPHE 443
            ..|..:|..|..|.:|        ||..|...|           .:.|.|:..|.|.| |:.|..
Worm   399 PSSRSTRLTRPYRTTH--------HLIPSSTRP-----------SSHQRPSLQPTAPRTRSCPRR 444

  Rat   444 ---SSGSGESYCTERSGYLADGPASDSSSGPCHGSSSDS 479
               .|.:...:.....||     :||.||.  |...|.|
Worm   445 RQLRSRNQIDFSIRIGGY-----SSDVSSS--HAEQSRS 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf43	XP_006247152.1	ZNRF_3_ecto	85..187	CDD:408039	23/123 (19%)
		RING-H2_RNF43	270..316	CDD:319712	29/65 (45%)
		dnaA	598..>743	CDD:237605
plr-1	NP_499473.2	zf-rbx1	305..358	CDD:289448	27/52 (52%)
plr-1	NP_499473.2	zf-RING_2	317..357	CDD:290367	26/39 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I6857
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138786at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto27722
orthoMCL	1	0.900	-	-		OOG6_118517
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.780