DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rnf43 and rnf43

DIOPT Version :9

Sequence 1:	XP_006247152.1	Gene:	Rnf43 / 303412	RGDID:	1305204	Length:	802	Species:	Rattus norvegicus
Sequence 2:	XP_002935238.2	Gene:	rnf43 / 100491274	XenbaseID:	XB-GENE-952685	Length:	689	Species:	Xenopus tropicalis

Alignment Length:	790	Identity:	305/790 - (38%)
Similarity:	411/790 - (52%)	Gaps:	178/790 - (22%)

- Green bases have known domain annotations that are detailed below.

  Rat     6 QLQLAVLWPWLLMATLHAGFGHTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGKL---NLTLEG 67
            :||||.|| .||..||.|       |.:|...:||..:.||:|||.||:.:.:|.:   ||||||
Frog     5 RLQLASLW-LLLTVTLQA-------VASAMGTTEREMDVKALIRVTPLQAEESGGVGQGNLTLEG 61

  Rat    68 VFAGVAEVSPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAGER 132
            :||.|||:|||||:|:|.|||.|||.|:||..:||||||||||:|.|..:||||||:|||:||||
Frog    62 LFARVAEISPAEGRLLQFHPLSLCNTSEDDQTKPGFISIVKLETPDRDTQPCLSLANKARLAGER 126

  Rat   133 GASAVLFDITEDRSAAEQLQQPLGLTKPVVLIWGSDAEKLMEFVYKNRKAYVWIELKEPPAWANY 197
            ||.|||||||.||.|.:|||||.|:.:|||||||.||||||:.|.||::|.|.||::|.|.|.::
Frog   127 GAHAVLFDITNDRGALQQLQQPAGINQPVVLIWGPDAEKLMDVVNKNKEALVKIEVQEQPKWLHH 191

  Rat   198 DVWILLTVVGTVFVIILASVLRIRCRPHPSRPDPLQQRTARAISQLATRRYQASC---RRARAEW 259
            |:||||||.|||...:|.:|.|:.||..|.: |.:||:|..|||:|.|||||...   :||...|
Frog   192 DIWILLTVAGTVMFFVLYAVARLLCRQPPPQ-DSIQQQTLLAISRLGTRRYQQRMLKDQRASGGW 255

  Rat   260 PDSGSSSSSAPVCAICLEEFTEGQELRVISCLHEFHRTCVDPWLHQHRTCPLCMFNIVEGDSFSQ 324
            .::.|:|||.|||||||||||:|||||::.|.||:|..||||||.|:.||||||::|::.
Frog   256 VETASTSSSVPVCAICLEEFTDGQELRILPCCHEYHLGCVDPWLRQNHTCPLCMYDILDS----- 315

  Rat   325 ALGASP---SYQEPGRRLHLIRQHPGHAHY--HLP--SAYLLGPSRNSVAQTPRPRPFLPSQEPS 382
              |..|   :::.|. :..|..::||.|..  |||  ...::.|:.|:....||...:|..
Frog   316 --GTPPRPLAHRAPS-QTQLWGRYPGSARLMSHLPPHGTPMVFPTPNNSLFLPRAPYYLDH---- 373

  Rat   383 MGSRHQRLPR------ASHLRAPEEQQHLAVSPGHPYAQGWGPNRLRCTSQHPNACPVALRRARP 441
              :.|.::|.      .:|.|..|..:.|.:|||
Frog   374 --THHWQMPEQMAMQMRTHRRGAEGTRELGISPG------------------------------- 405

  Rat   442 HESSGSGESYCTERSGYLADGPASDSSSGPCHGSSSDSVVNCTDISLQGVHG-SSSTFRSSLSSD 505
                      |.:.||||.|.|.|||||||||||||:   |||||||..:|| |||:..||.|:.
Frog   406 ----------CQDSSGYLPDDPGSDSSSGPCHGSSSE---NCTDISLHCLHGTSSSSVHSSQSNQ 457

  Rat   506 FD---PLV--YCSPEGALQGKEVQPSMTSRPRSLDSVVPTGETQVS--SHIHYHRHRHHHYKKQF 563
            .|   |.:  |..|:|.|      |::.          |...||.|  ||:|:|:||||||::
Frog   458 EDSSPPALASYLLPQGEL------PALN----------PLLSTQASYASHVHFHQHRHHHYRR-- 504

  Rat   564 QWHSRKPGLETGVP-QSRPAASHTQLEPSL--PDQQLTTPNPAVSSML----PNPQRPRALTEP- 620
                .:|.:....| :|:.....::.:||.  ..:..|..|..:.|::    |.|...|...:|
Frog   505 ----NQPSMSHSHPHRSKRRTKVSRADPSYYREHRHTTGANGELRSLMVRREPRPSCSRTCFDPR 565

  Rat   621 -----------APGLAEAVSPSPSPN-PSLLNLQKSNLPVRYPQRKRRGGPSEALPTSQPQDLTV 673
                       .|..|..|..|..|: .:.|...:::.|.|..::|:...||.
Frog   566 TNREHPRHQQSMPQAASVVQGSSEPDVATSLRGSRTDPPSRTYRKKKSSAPSH------------ 618

  Rat   674 HTACPVPPHYSPSLAYP-------------WPPEVHPLIFRPPGLDRRLLHDVPGPCYSSSQPVW 725
                 :|..|||...:|             |..||            ||||........::..:.
Frog   619 -----LPLLYSPRHCHPANSVQMSESSHPRWAEEV------------RLLHSRVNSHRENTAMMH 666

  Rat   726 LYLNPRQPLG 735
            ||..|....|
Frog   667 LYHPPHHNQG 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf43	XP_006247152.1	ZNRF_3_ecto	85..187	CDD:408039	70/101 (69%)
		RING-H2_RNF43	270..316	CDD:319712	33/45 (73%)
		dnaA	598..>743	CDD:237605	34/168 (20%)
rnf43	XP_002935238.2	ZNRF_3_ecto	80..182	CDD:375639	71/101 (70%)
		HRD1	<244..366	CDD:227568	53/129 (41%)
		RING-H2_RNF43_like	267..311	CDD:319580	32/43 (74%)
		RING-H2 finger (C3H2C3-type)	268..308	CDD:319580	28/39 (72%)
		DUF4573	523..643	CDD:373595	25/136 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	148	1.000	Domainoid score	I20357
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I8058
OMA	1	1.010	-	-		QHG38388
OrthoDB	1	1.010	-	-		D138786at33208
OrthoFinder	1	1.000	-	-		FOG0013512
OrthoInspector	1	1.000	-	-		oto210646
Panther	1	1.100	-	-	LDO	PTHR16200
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080