DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hoxb3a and Scr

DIOPT Version :9

Sequence 1:	NP_571192.2	Gene:	hoxb3a / 30339	ZFINID:	ZDB-GENE-990415-104	Length:	417	Species:	Danio rerio
Sequence 2:	NP_001368995.1	Gene:	Scr / 40833	FlyBaseID:	FBgn0003339	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	450	Identity:	127/450 - (28%)
Similarity:	171/450 - (38%)	Gaps:	136/450 - (30%)

- Green bases have known domain annotations that are detailed below.

Zfish    15 GYSYQGANGF-----GY------DAPAPAFQNSAHLEG-------DY---QRSACSLQSLGTSAP 58
            |.:..|||.:     .|      :.|...:.|.|...|       ||   |.....||.  ....
  Fly    66 GAATPGANDYFPAAAAYTPNLYPNTPQAHYANQAAYGGQGNPDMVDYTQLQPQRLLLQQ--QQQQ 128

Zfish    59 PQPQHAKTKELNGSCMRPSLPPEHHPPPQVSPPQNTVNVAATNATQQPGGSGGGGVAGSGGTSKS 123
            .|.|||.......:..:..|..:.||..|....|..::....|....|||||||||:||...:.|
  Fly   129 QQQQHAHAAAAVAAQQQQQLAQQQHPQQQQQQQQANISCKYANDPVTPGGSGGGGVSGSNNNNNS 193

Zfish   124 ----SSKSSSMATNPTL-TKQIFPWMKESR--------------------------QNTKQKNS- 156
                ::.|.|:|:...| |:.|.|.:..|.                          .|.....|
  Fly   194 ANSNNNNSQSLASPQDLSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSG 258

Zfish   157 -------------SPSASSANAES-----------SG-GEKSPP-----------------GSAA 179
                         ||....:::||           || |:|:||                 .:..
  Fly   259 VSGGPGNVNVPMHSPGGGDSDSESDSGNEAGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNANGE 323

Zfish   180 SKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKSKGI 244
            :||.||:||..|.:||||||||||||.|.||:|:|:.|.|:||||||||||||||:||:.|...:
  Fly   324 TKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKMASM 388

Zfish   245 GSSSGGPSPTGSP-----PLPMQ-SSAGFMNSMHSMGSYDAPSPPSFNKPHQNAYAMSTA--YQN 301
            ........|.|.|     ..|.| :.... ::.|..|: . .....:.:|:|.|.|.|.|  ||:
  Fly   389 NIVPYHMGPYGHPYHQFDIHPSQFAHLSAXDAWHFSGT-GXRLNQLYQEPYQTAAAASAASGYQS 452

Zfish   302 ----PMKGCPPQQKYGNTPPDYDPHGLQGNSGNYGTPNMQGSPVYVGGNYVDAMPATGPS 357
                |:.|                 |..|..|..|.|   ||....|.|      .:||:
  Fly   453 QDGGPIGG-----------------GSVGVGGGAGGP---GSLANGGSN------GSGPN 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hoxb3a	NP_571192.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..135		26/87 (30%)
		Antp-type hexapeptide	140..145		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..184		15/105 (14%)
		Homeobox	184..236	CDD:278475	38/51 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..290		10/58 (17%)
		DUF4074	353..415	CDD:290032	2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..417
Scr	NP_001368995.1	Homeobox	328..381	CDD:395001	38/52 (73%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810