DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pou6f1 and pdm2

DIOPT Version :9

Sequence 1:	NP_571188.1	Gene:	pou6f1 / 30334	ZFINID:	ZDB-GENE-980526-530	Length:	610	Species:	Danio rerio
Sequence 2:	NP_001285877.1	Gene:	pdm2 / 34673	FlyBaseID:	FBgn0004394	Length:	893	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	130/511 - (25%)
Similarity:	194/511 - (37%)	Gaps:	141/511 - (27%)

- Green bases have known domain annotations that are detailed below.

Zfish   187 LAAASPAGGLLKLPFAGLQAATVLNSVQTQLQAPAQAVLQPQMSALQAMQQTQTTAATTASIVQK 251
            |..|.|..|...||              |..|.|...||.|..::.             ::||..
  Fly   384 LHIAPPRAGPTPLP--------------THQQPPVGEVLPPNSTSF-------------STIVDP 421

Zfish   252 ASEPSV-----------------------------SVATLQTAGLSINPAIISAASLGAQPQFIS 287
            ..|||:                             .:.:|...|.|.....:........||.:|
  Fly   422 PKEPSIYEQPAPNGRHCRPANKVMRHMSNSPTPPSPLRSLSDCGKSFEEEELELGENCEMPQNLS 486

Zfish   288 SLTTTPIITSAMSN----VAGLTSQLITNAQGQVIGTLPLLVNPASLAGAAAASALPAQGLQVQ- 347
            |......:.|.:.|    :|....:|....:.:.:.:    |||..  ..|.|.....|.||:|
  Fly   487 SKRQARELDSELENEVLDLAPPPKRLAEEQEEEKVAS----VNPPQ--PVAFAPEEMHQALQLQL 545

Zfish   348 ------------------TVAPQLLLNSQGQIIATIG-----------------NGPTAAIP--- 374
                              .:|.|.||.:..|.:|...                 :.|.|..|
  Fly   546 HSYIEMVRQLAPEAFPNPNLATQFLLQNSLQALAQFQALQQMKQQQREDPLPSYSTPLAKSPLRS 610

Zfish   375 STASVLPK------ATVPLTLTKTTTQGPVGKVAPSKVIIAPQP----SVVKPVTSLTAAGVIAC 429
            .:.|.:|:      .|.|.::|..:.......:.|:...:..||    |..||.:.||.|..:|
  Fly   611 PSLSPVPRHSKSQQRTPPNSMTANSLGMSSAVMTPNTPSMQQQPQLQQSTPKPTSGLTVASAMA- 674

Zfish   430 GEMPTVGQLVNKPSAVKDEEAINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAI 494
                   :|...|     ||..:|||:.:|||.||.||:.||.||..||.|:....|..:||:.|
  Fly   675 -------KLEQSP-----EETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTI 727

Zfish   495 CRFEKLDITPKSAQKLKPVLERWLAEAELWNQKGQ------QNLMEFVGGEP----SKKRKRRTS 549
            .|||.|:::.|:..||||:|::||.:|:....|..      ..:...:...|    .::||:|||
  Fly   728 SRFEALNLSFKNMCKLKPLLQKWLEDADSTVAKSGGGVFNINTMTSTLSSTPESILGRRRKKRTS 792

Zfish   550 FTPQAIEVLNTYFEKNSLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKIN 605
            ........|...|..|..||.:||:::::.||.|:||:|||||||||..|   :||
  Fly   793 IETTVRTTLEKAFLMNCKPTSEEISQLSERLNMDKEVIRVWFCNRRQKEK---RIN 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pou6f1	NP_571188.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..87
		POU	448..522	CDD:197673	35/73 (48%)
		Homeobox	546..599	CDD:278475	24/52 (46%)
pdm2	NP_001285877.1	POU	691..755	CDD:197673	30/63 (48%)
pdm2	NP_001285877.1	Homeobox	789..842	CDD:278475	24/52 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810