DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ephb3a and Eph

DIOPT Version :9

Sequence 1:	XP_017213105.1	Gene:	ephb3a / 30313	ZFINID:	ZDB-GENE-990415-60	Length:	961	Species:	Danio rerio
Sequence 2:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster

Alignment Length:	1084	Identity:	424/1084 - (39%)
Similarity:	571/1084 - (52%)	Gaps:	202/1084 - (18%)

- Green bases have known domain annotations that are detailed below.

Zfish     7 LLLYSLWVPVILAVEETLMD-SRWATTELAWTTYP------ESGWEEVSGYDDHLSPI--RTYQV 62
            |::.|:...:..|.:..|:| :|.||.|  ||.||      ..||.|.| :.|.:..|  |:|.|
  Fly    70 LIIISIHFKLAHADQVVLLDTTREATLE--WTRYPYGPQAQTPGWVEES-FTDFVKGINWRSYVV 131

Zfish    63 CNVLEPNQNNWLRTDFIPRRGVLRVYVELKFSVRDCGSIPNIPGSCKETFNLFYYESDGDMATAS 127
            |:|...|.||||.:.||.|....|:|:|::|::|||...|....||||||:|.:||.|.  ||..
  Fly   132 CDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDA--ATRE 194

Zfish   128 SPPWRENPYVKVDTIAPDES-FSLLESGIVNTKVRSFGPLSKAGFYLAFQDLGACMSLISARVFF 191
            .|||:.:.|..:..||..|. |:......:||:|:|.. ::|.|.|.||:|.|||:|:::.:|::
  Fly   195 PPPWQTDSYRLIARIAAGEGRFNQNSDVDINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYY 258

Zfish   192 KKCSTSIANFAVFPETATGAEATSLVIAAGACVPNAAEESVPLKLYCNGDGEWMVPVGACTCMPG 256
            ..|.....|||.|.||.||.|.|.:....|.||.||.....|..| |.|||:|.:..|.|.|..|
  Fly   259 ITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYL-CKGDGKWTILTGGCRCKAG 322

Zfish   257 FEPAKKDTQCQACTPGTFKSKQGEGSCMPCPSNSRASSRASSVCPCQSGYYRADSDLPDTACTTV 321
            :||...:..|..|..|||||.: ...|.|||.||.||...|..|.|.||:||..:|.....|.:.
  Fly   323 YEPNYTNKTCTECPLGTFKSPE-VTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSP 386

Zfish   322 PSAPLNV-ISSVNETSVSLEWSEPRDSGG----------RGDVVYNVVCKKCLHDGGSCARCDDN 375
            |:||.|: :..|::||..:.||.|..:..          ..|:||.:          .|..|..|
  Fly   387 PAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI----------KCNICSPN 441

Zfish   376 VEVSPRRLGLAERQAAVRNLQAHTHYSFEIQAVNGVS-------PKSPSS---------PQYTTV 424
            |..:|......|.:..:.||:..|.|:.:|.|:|.||       ..:.||         ...:.:
  Fly   442 VVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLL 506

Zfish   425 NI----------------TTNQAAPSAVPTVHLMRATAGTLSLSWLPPEQPNGVILDYEIKYQER 473
            ||                ||.....|.|..:.::..|.....|.|..|.|.:..:..||:::..:
  Fly   507 NIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPK 571

Zfish   474 GESFS---HTVTAQHTSAKVEGLKAGTVYSVQVRARTVAGYGRYSNPVDFSTSLYVYPVSSSSTS 535
            .|..:   ..:..:.|.|.:.||...|.|..|||.:|..|:|.|||.: ::.:|      .|..|
  Fly   572 VELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMI-YAQTL------QSVGS 629

Zfish   536 VHLRCREELTTTTTGFKSREERFQKSDDPERSVQDLLPLIVGSASAGFVVILAMIVIAVVCLRRQ 600
            |:                        ||   |||  :..|.|:...| |:.|.:.:||.|...|.
  Fly   630 VY------------------------DD---SVQ--IRFIAGAIVTG-VLFLVIFIIATVYFMRS 664

Zfish   601 RTGSELE-------------------------YTEKLQQYVSPGV----KVYIDPFTYEDPNEAV 636
            :...:|:                         ..:||...|:..:    :.|:||.||||||:|:
  Fly   665 KHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAI 729

Zfish   637 HEFAREIDISCVKIEEVIGAGEFGEVCRGRLKQAGR--KETTVAIKTLKAGYTEHQRRDFLSEAS 699
            .|||||||.:.:.||.:||.||||:|||||||....  ::..|||||||.|.:|..|.|||:|||
  Fly   730 REFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEAS 794

Zfish   700 IMGQFDHPNVIHLEGVLTRSCPVLIVTEFMENGALDSFLRLNDGRFTVTQLVGMLRGIAAGMKYL 764
            |||||||||||:|:||:|||.||:|:||:||||:||:|||:|||:|...||:.||||||:||.||
  Fly   795 IMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYL 859

Zfish   765 SDMNYVHRDLAARNVLVNSNLVCKVSDFGLSRFLDDNSSDPTYTSSLGGKIPIRWTAPEAIAFRK 829
            ||||||||||||||||||:.|:||::||||||.: :|:|| .||:. |||||:||||||||||||
  Fly   860 SDMNYVHRDLAARNVLVNAQLICKIADFGLSREI-ENASD-AYTTR-GGKIPVRWTAPEAIAFRK 921

Zfish   830 FTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVMNAVEQDYRLPPPMDCPAVLHQLMLECWVKER 894
            |||||||||||:|:|||||:||||||:.|||||:.::|:.||||.|||||..|:||||:||.|:|
  Fly   922 FTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQR 986

Zfish   895 NMRPRFGQIVSTLDKLLR----------------------------------------------- 912
            ..||.|..||||||.|.|
  Fly   987 THRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHH 1051

Zfish   913 -------NAASLKVLTSTHSGDLCRIGGTLPGHQRKSIGDAQDI 949
                   ||..:..||:....|:   |.||.|||:|.:..|:.:
  Fly  1052 FKEANLINAQQISRLTAQQLSDM---GITLVGHQKKILHQARQL 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ephb3a	XP_017213105.1	None
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	72/180 (40%)
		FN3	387..476	CDD:238020	25/98 (26%)
		FN3	536..623	CDD:238020	23/87 (26%)
		EphA2_TM	644..736	CDD:291255	25/92 (27%)
		PTKc_EphR	736..1002	CDD:270629	185/268 (69%)
		Pkinase_Tyr	741..999	CDD:285015	180/260 (69%)
		SAM_1	1033..1092	CDD:278937	13/61 (21%)
		SAM	1039..1092	CDD:197735	13/55 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	396	1.000	Domainoid score	I723
eggNOG	1	0.900	-	-		E2759_KOG0196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.680