DRSC/TRiP Functional Genomics Resources

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Protein Alignment ek1 and Eph

DIOPT Version :9

Sequence 1:NP_571170.1 Gene:ek1 / 30311 ZFINID:ZDB-GENE-990415-58 Length:981 Species:Danio rerio
Sequence 2:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster


Alignment Length:1045 Identity:431/1045 - (41%)
Similarity:590/1045 - (56%) Gaps:148/1045 - (14%)


- Green bases have known domain annotations that are detailed below.


Zfish    28 NEVTLLDSMSAPGDLGWEAYP------SEGWEEISVMD-ERNIPMRTYQVCNVMEANQNNWLRTG 85
            ::|.|||: :....|.|..||      :.||.|.|..| .:.|..|:|.||:|...|.||||.:.
  Fly    83 DQVVLLDT-TREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYHNVNNWLWSP 146

Zfish    86 LIQREGAQRVYVEIKFTLRDCNSLPGVPGTCKETFNVYYHESNNAVAAPLRHIRESQYIKIDTIA 150
            .|.|..|.|:|:||:||:|||:..||...:|||||::.::|.:.|...|.....:| |..|..||
  Fly   147 FIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDS-YRLIARIA 210

Zfish   151 ADES-FTQTDVGDRVMKLNTEVRDISGLSKRGLYLAFQDLGACIALVSVRVFYKRCPLAVLNLAR 214
            |.|. |.|....|    :||||:.|: ::|:|:|.||:|.||||::::|:|:|..||....|.|.
  Fly   211 AGEGRFNQNSDVD----INTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAH 270

Zfish   215 FPDTVTGGDSALVEVR-GTCVEDAEELEGPRMFCSADGGWLVPIGRCVCRPGFEE--VDGHCQPC 276
            |.:|.||.:..::|.: ||||::||..|.|...|..||.|.:..|.|.|:.|:|.  .:..|..|
  Fly   271 FNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTEC 335

Zfish   277 RSGFYKASAMDAYCVKCPPHSYSHQDKASECVCERGFYRAESDPRSMACTRPPSAPGN-PISMVN 340
            ..|.:|:..: ..|..|||:|.:.:..:..|.|..||||..:|.|.|.|..||:||.| .:..|:
  Fly   336 PLGTFKSPEV-TKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVD 399

Zfish   341 ETAVTLEWSPPRDSGG----------RGDVSYSVHCRKCSGETGASERCVPCGSGAHFNPRQFGL 395
            :|:..:.||.|..:..          ..|:.|.:.|..||             ....:||.....
  Fly   400 QTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICS-------------PNVVYNPSTDTF 451

Zfish   396 THPRVLVTELQPHTNYTFSVEALNGVSDLSPSPR-----QLVSVN------------------VT 437
            ...::.:|.|:|.|.||..:.|:|.||.::...|     .||:|:                  |.
  Fly   452 NETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVK 516

Zfish   438 TSQ------TVSVILK----------ERKGTDSVTLAWQGPEPVDGTVVEYEVTYYEKNQQDQ-N 485
            |.|      |.||:|.          ..|..|   |.|..|...|..:..|||.::.|.:.|. |
  Fly   517 TGQAEIVFTTESVLLSTVFNLRILAITNKDAD---LEWDKPVQSDFPLEFYEVRWFPKVELDAIN 578

Zfish   486 YTVLKTKSNSMTVDGLKPGTTYIFRVRARTDGGYGNYKGEIELETSHEDMLAVGDPNQQTILAIS 550
            .:.|.||.....:.||...|.|.|:||.:|:.|:|:|...|..:|    :.:||.....::....
  Fly   579 KSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQT----LQSVGSVYDDSVQIRF 639

Zfish   551 VAGGAVLLVLLVACFIVSGRRCGYIKAKQDPEEEKMQFQHGRVKLP------------------- 596
            :||..|..||.:..||::  ...::::|...:.:|....|  :.||                   
  Fly   640 IAGAIVTGVLFLVIFIIA--TVYFMRSKHQDDLDKKSTNH--LPLPLDYASNEVNSMDTTPIVKK 700

Zfish   597 -----------ETRTYIHPHTYEDPNQAVRDFAKEIEVSNIRIERVIGAGEFGEVCSGRLRLPSK 650
                       .:|:|:.||||||||||:|:||:||:.:.|.||.:||.||||:||.|||::|..
  Fly   701 LHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPN 765

Zfish   651 --REIQVAIKSLKAGYSEHQRRDFLSEASIMGQFDHPNIIRLEGVVTRCKPVMIVTEYMENGSLD 713
              ::|.||||:||.|.||..|.|||:||||||||||||:|.|:|||||..||||:||||||||||
  Fly   766 FVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLD 830

Zfish   714 TFLKKHDGQFTVIQLLGMLRGIAAGMQYLSEMNYVHRDLAARNILVNRNLVCKVSDFGLSRVLED 778
            |||:.:||:|..:||:.||||||:||.|||:||||||||||||:|||..|:||::||||||.:|:
  Fly   831 TFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIEN 895

Zfish   779 DPEAAYTTRGGKIPIRWTAPEAITYRKFTSASDVWSYGIVMWEVISYGERPYWEMSNQDVIKAVD 843
            ..: ||||||||||:||||||||.:|||||||||||||:|:|||:||||||||..|||||||:::
  Fly   896 ASD-AYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIE 959

Zfish   844 EGYRLPAPMDCPVVLHQLMLDCWEKNRSDRPKFGQIVNTLDRLIRNPSSLKQLANSAVWEDPVTP 908
            :|||||||||||..|:|||||||:|.|:.||.|..||:|||.|.|.|.||.....|        |
  Fly   960 KGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPS--------P 1016

Zfish   909 EAAVNTVED-------------WLDLIKMGQYKEHFSSAGYVTLDSVLYVSSSELDKMGVELAGH 960
            |:..|.:.|             ||:.|||.:|..||..|..:....:..:::.:|..||:.|.||
  Fly  1017 ESDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGH 1081

Zfish   961 QKKIL 965
            |||||
  Fly  1082 QKKIL 1086

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ek1NP_571170.1 Ephrin_lbd 30..204 CDD:279712 74/181 (41%)
fn3 330..427 CDD:278470 25/107 (23%)
FN3 426..530 CDD:238020 38/143 (27%)
EphA2_TM 550..621 CDD:291255 27/100 (27%)
PTKc_EphR_A 621..887 CDD:270651 186/267 (70%)
Pkinase_Tyr 626..883 CDD:285015 182/258 (71%)
SAM_EPH-R 911..971 CDD:188887 22/68 (32%)
SAM 912..974 CDD:197735 22/67 (33%)
PDZ-binding. /evidence=ECO:0000255 979..981
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 74/181 (41%)
FN3 387..476 CDD:238020 23/101 (23%)
FN3 536..623 CDD:238020 27/89 (30%)
EphA2_TM 644..736 CDD:291255 25/95 (26%)
PTKc_EphR 736..1002 CDD:270629 186/266 (70%)
Pkinase_Tyr 741..999 CDD:285015 182/258 (71%)
SAM_1 1033..1092 CDD:278937 20/54 (37%)
SAM 1039..1092 CDD:197735 20/48 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 396 1.000 Domainoid score I723
eggNOG 1 0.900 - - E2759_KOG0196
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 753 1.000 Inparanoid score I540
OMA 1 1.010 - - QHG45908
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm24639
orthoMCL 1 0.900 - - OOG6_100189
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X82
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1312.880

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