Protein Alignment ek1 and Eph

DIOPT Version :10

• Sequence 1: NP_571170.1
• Gene: ek1 / 30311
• ZFINID: ZDB-GENE-990415-58
• Length: 981
• Species: Danio rerio
• Sequence 2: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Alignment Length: 1045
• Identity: 431/1045 - (41%)
• Similarity: 590/1045 - (56%)
• Gaps: 148/1045 - (14%)

Zfish    28 NEVTLLDSMSAPGDLGWEAYP------SEGWEEISVMD-ERNIPMRTYQVCNVMEANQNNWLRTG 85
            ::|.|||: :....|.|..||      :.||.|.|..| .:.|..|:|.||:|...|.||||.:.
  Fly    83 DQVVLLDT-TREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYHNVNNWLWSP 146

Zfish    86 LIQREGAQRVYVEIKFTLRDCNSLPGVPGTCKETFNVYYHESNNAVAAPLRHIRESQYIKIDTIA 150
            .|.|..|.|:|:||:||:|||:..||...:|||||::.::|.:.|...|.....:| |..|..||
  Fly   147 FIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDS-YRLIARIA 210

Zfish   151 ADES-FTQTDVGDRVMKLNTEVRDISGLSKRGLYLAFQDLGACIALVSVRVFYKRCPLAVLNLAR 214
            |.|. |.|....|    :||||:.|: ::|:|:|.||:|.||||::::|:|:|..||....|.|.
  Fly   211 AGEGRFNQNSDVD----INTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAH 270

Zfish   215 FPDTVTGGDSALVEVR-GTCVEDAEELEGPRMFCSADGGWLVPIGRCVCRPGFEE--VDGHCQPC 276
            |.:|.||.:..::|.: ||||::||..|.|...|..||.|.:..|.|.|:.|:|.  .:..|..|
  Fly   271 FNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTEC 335

Zfish   277 RSGFYKASAMDAYCVKCPPHSYSHQDKASECVCERGFYRAESDPRSMACTRPPSAPGN-PISMVN 340
            ..|.:|:..: ..|..|||:|.:.:..:..|.|..||||..:|.|.|.|..||:||.| .:..|:
  Fly   336 PLGTFKSPEV-TKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVD 399

Zfish   341 ETAVTLEWSPPRDSGG----------RGDVSYSVHCRKCSGETGASERCVPCGSGAHFNPRQFGL 395
            :|:..:.||.|..:..          ..|:.|.:.|..||             ....:||.....
  Fly   400 QTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICS-------------PNVVYNPSTDTF 451

Zfish   396 THPRVLVTELQPHTNYTFSVEALNGVSDLSPSPR-----QLVSVN------------------VT 437
            ...::.:|.|:|.|.||..:.|:|.||.::...|     .||:|:                  |.
  Fly   452 NETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVK 516

Zfish   438 TSQ------TVSVILK----------ERKGTDSVTLAWQGPEPVDGTVVEYEVTYYEKNQQDQ-N 485
            |.|      |.||:|.          ..|..|   |.|..|...|..:..|||.::.|.:.|. |
  Fly   517 TGQAEIVFTTESVLLSTVFNLRILAITNKDAD---LEWDKPVQSDFPLEFYEVRWFPKVELDAIN 578

Zfish   486 YTVLKTKSNSMTVDGLKPGTTYIFRVRARTDGGYGNYKGEIELETSHEDMLAVGDPNQQTILAIS 550
            .:.|.||.....:.||...|.|.|:||.:|:.|:|:|...|..:|    :.:||.....::....
  Fly   579 KSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQT----LQSVGSVYDDSVQIRF 639

Zfish   551 VAGGAVLLVLLVACFIVSGRRCGYIKAKQDPEEEKMQFQHGRVKLP------------------- 596
            :||..|..||.:..||::  ...::::|...:.:|....|  :.||
  Fly   640 IAGAIVTGVLFLVIFIIA--TVYFMRSKHQDDLDKKSTNH--LPLPLDYASNEVNSMDTTPIVKK 700

Zfish   597 -----------ETRTYIHPHTYEDPNQAVRDFAKEIEVSNIRIERVIGAGEFGEVCSGRLRLPSK 650
                       .:|:|:.||||||||||:|:||:||:.:.|.||.:||.||||:||.|||::|..
  Fly   701 LHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPN 765

Zfish   651 --REIQVAIKSLKAGYSEHQRRDFLSEASIMGQFDHPNIIRLEGVVTRCKPVMIVTEYMENGSLD 713
              ::|.||||:||.|.||..|.|||:||||||||||||:|.|:|||||..||||:||||||||||
  Fly   766 FVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLD 830

Zfish   714 TFLKKHDGQFTVIQLLGMLRGIAAGMQYLSEMNYVHRDLAARNILVNRNLVCKVSDFGLSRVLED 778
            |||:.:||:|..:||:.||||||:||.|||:||||||||||||:|||..|:||::||||||.:|:
  Fly   831 TFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIEN 895

Zfish   779 DPEAAYTTRGGKIPIRWTAPEAITYRKFTSASDVWSYGIVMWEVISYGERPYWEMSNQDVIKAVD 843
            ..: ||||||||||:||||||||.:|||||||||||||:|:|||:||||||||..|||||||:::
  Fly   896 ASD-AYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIE 959

Zfish   844 EGYRLPAPMDCPVVLHQLMLDCWEKNRSDRPKFGQIVNTLDRLIRNPSSLKQLANSAVWEDPVTP 908
            :|||||||||||..|:|||||||:|.|:.||.|..||:|||.|.|.|.||.....|        |
  Fly   960 KGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPS--------P 1016

Zfish   909 EAAVNTVED-------------WLDLIKMGQYKEHFSSAGYVTLDSVLYVSSSELDKMGVELAGH 960
            |:..|.:.|             ||:.|||.:|..||..|..:....:..:::.:|..||:.|.||
  Fly  1017 ESDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGH 1081

Zfish   961 QKKIL 965
            |||||
  Fly  1082 QKKIL 1086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ek1	NP_571170.1	EphR_LBD_A	29..204	CDD:198441	74/182 (41%)
		FN3	<326..>563	CDD:442628	73/287 (25%)
		fn3	451..522	CDD:394996	24/71 (34%)
		EphA2_TM	547..623	CDD:464211	29/105 (28%)
		PTKc_EphR_A	621..887	CDD:270651	186/267 (70%)
		SAM_EPH-R	911..971	CDD:188887	22/68 (32%)
		PDZ-binding. /evidence=ECO:0000255	979..981
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	74/181 (41%)
		FN3	387..476	CDD:238020	23/101 (23%)
		FN3	536..623	CDD:238020	27/89 (30%)
		EphA2_TM	640..738	CDD:464211	29/101 (29%)
		PTKc_EphR	736..1002	CDD:270629	186/266 (70%)
		SAM_1	1029..1092	CDD:425739	20/58 (34%)