DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment atoh1a and twi

DIOPT Version :9

Sequence 1:	NP_571166.2	Gene:	atoh1a / 30303	ZFINID:	ZDB-GENE-990415-17	Length:	292	Species:	Danio rerio
Sequence 2:	NP_001033967.1	Gene:	twi / 37655	FlyBaseID:	FBgn0003900	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	207	Identity:	65/207 - (31%)
Similarity:	86/207 - (41%)	Gaps:	49/207 - (23%)

- Green bases have known domain annotations that are detailed below.

Zfish    18 HSSLGRGEQSEYPPALALMASSDPRAWLAPVQAGTCAAHAEYLLHSPGSSAEGVSSASN-FRKSS 81
            :||..| :..||....||.:.||..   ..|.:..|.|..    .|.||..:|..:... |||..
  Fly   288 YSSSDR-DDMEYARHNALSSVSDLN---GGVMSPACLADD----GSAGSLLDGSDAGGKAFRKPR 344

Zfish    82 KSPVKVRELCRLKGAVGADEGRQRAPS-SKSTNVVQKQRRMAANARERRRMHGLNHAFDELRSVI 145
            :         |||          |.|| ::.|:....||.| ||.|||:|...||.||..|:.:|
  Fly   345 R---------RLK----------RKPSKTEETDEFSNQRVM-ANVRERQRTQSLNDAFKSLQQII 389

Zfish   146 PAFDNDKKLSKYETLQMAQIYINALSDLL-------------QG-PGAKADPPNCDLLHANVLET 196
            |...:| ||||.:||::|..||:.|..:|             || |.|.....:.....||..|.
  Fly   390 PTLPSD-KLSKIQTLKLATRYIDFLCRMLSSSDISLLKALEAQGSPSAYGSASSLLSAAANGAEA 453

Zfish   197 D----RSPRGSP 204
            |    |...|:|
  Fly   454 DLKCLRKANGAP 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atoh1a	NP_571166.2	HLH	117..175	CDD:238036	28/70 (40%)
twi	NP_001033967.1	HLH	363..413	CDD:278439	26/51 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910