DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment her4.5 and E(spl)m5-HLH

DIOPT Version :9

Sequence 1:	NP_571165.3	Gene:	her4.5 / 30301	ZFINID:	ZDB-GENE-081031-106	Length:	152	Species:	Danio rerio
Sequence 2:	NP_524511.1	Gene:	E(spl)m5-HLH / 43158	FlyBaseID:	FBgn0002631	Length:	178	Species:	Drosophila melanogaster

Alignment Length:	184	Identity:	54/184 - (29%)
Similarity:	79/184 - (42%)	Gaps:	38/184 - (20%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MAPTITGS---ISSRETLLTNKLRKPMVEKIRRERINSSIEKLKTLLAQEFVKQQPDSRQEKADI 62
            |||....|   :|..:..|  |::||::|:.||.|:|..::.||||:| ||.......|.:||::
  Fly     1 MAPQSNNSTTFVSKTQHYL--KVKKPLLERQRRARMNKCLDTLKTLVA-EFQGDDAILRMDKAEM 62

Zfish    63 LEMTLDFLRRSQKSSAAG------DGRSRCVQEAVSFLSQCPVQTQS------HTRLMKLFLHMQ 115
            ||..|.|:|:......|.      |........|||.:|:....|.:      .|.:..|.:..|
  Fly    63 LEAALVFMRKQVVKQQAPVSPLPMDSFKNGYMNAVSEISRVMACTPAMSVDVGKTVMTHLGVEFQ 127

Zfish   116 --TPADQHTRVDNPQTTET-----------HANS----SAKQHTPAHSHIWRPW 152
              ..|||   |....||.|           |:::    ||....|....:||||
  Fly   128 RMLQADQ---VQTSVTTSTPRPLSPASSGYHSDNEDSQSAASPKPVEETMWRPW 178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
her4.5	NP_571165.3	HLH	19..75	CDD:238036	23/55 (42%)
her4.5	NP_571165.3	ORANGE	77..123	CDD:128787	13/59 (22%)
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	22/52 (42%)
E(spl)m5-HLH	NP_524511.1	ORANGE	87..131	CDD:128787	9/43 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573752
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1378299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940