Protein Alignment HADHA and DCI1

DIOPT Version :10

• Sequence 1: NP_000173.2
• Gene: HADHA / 3030
• HGNCID: 4801
• Length: 763
• Species: Homo sapiens
• Sequence 2: NP_014823.3
• Gene: DCI1 / 854352
• SGDID: S000005706
• Length: 271
• Species: Saccharomyces cerevisiae
• Alignment Length: 301
• Identity: 64/301 - (21%)
• Similarity: 109/301 - (36%)
• Gaps: 82/301 - (27%)

Human    39 THINYGVKGDVAVVRINSPNSKVNTLSKE--------LHSEFSEVMNEIWASDQIRSAVLIS--- 92
            :.:.|.:.|...::::..| ..:|:|:.|        ||.     .|:|   |.:...||.|
Yeast     3 SRVCYHINGPFFIIKLIDP-KHLNSLTFEDFVYIALLLHK-----ANDI---DSVLFTVLQSSGK 58

Human    93 --SKPGCFIAGADINMLAACKTLQEVTQLSQEAQRIVEKLEKST-----------KPIVAAINGS 144
              |..|.|.|   :|.|.......||.::|    ::|..:....           |.:|..:||.
Yeast    59 YFSSGGKFSA---VNKLNDGDVTSEVEKVS----KLVSAISSPNIFVANAFAIHKKVLVCCLNGP 116

Human   145 CLGGGLEVAISCQYRIATKDRKTVLGTPEVLLGALPGAGGTQRLPKMVGVPAALDMMLTGRSIRA 209
            .:|....:...|....:..|...:| .|...||.:...|.:..|.:.:|:.:|.:.|:....:
Yeast   117 AIGLSASLVALCDIVYSQNDSVFLL-FPFSNLGFVAEVGTSVTLTQKLGINSANEHMIFSTPV-- 178

Human   210 DRAKKMGLVDQLVEPLGPGLKPPEERTIEYLEEVAITF-AKGLADKK-----ISPKRDKGLVEKL 268
                   |..:|:..:         .|..|......|| .|.|.|.|     :.||...|:.|.|
Yeast   179 -------LFKELIGTI---------ITKNYQLTNTETFNEKVLQDIKQNLEGLYPKSVLGMKELL 227

Human   269 ---------TAYAM----TIPFVRQ----QVYKKVEEKVRK 292
                     .|.||    |:||...    :.:|:::|..|:
Yeast   228 HSEMKQKLIKAQAMETNGTLPFWASGEPFKRFKQLQEGNRR 268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HADHA	NP_000173.2	fa_ox_alpha_mit	27..762	CDD:131494	64/301 (21%)
DCI1	NP_014823.3	crotonase-like	7..178	CDD:119339	40/187 (21%)