Protein Alignment HADHA and Echs1

DIOPT Version :10

• Sequence 1: NP_000173.2
• Gene: HADHA / 3030
• HGNCID: 4801
• Length: 763
• Species: Homo sapiens
• Sequence 2: NP_610910.1
• Gene: Echs1 / 36536
• FlyBaseID: FBgn0033879
• Length: 295
• Species: Drosophila melanogaster
• Alignment Length: 290
• Identity: 90/290 - (31%)
• Similarity: 137/290 - (47%)
• Gaps: 63/290 - (21%)

Human    25 ICRNFTGSSALLTRTHINYGVKGD---VAVVRINSPNSKVNTLSKELHSEFSEVMNEIWASDQIR 86
            :...|:.||......:|...|.|:   |.|:.:|.|.: :|.|...|..|.|..:.: ::.|:..
  Fly    25 VATRFSSSSTNNNWEYIKTEVAGEGKNVGVITLNRPKA-LNALCNGLMKELSTALQQ-FSKDKTI 87

Human    87 SAVLISSKPGCFIAGADI-----NMLAAC---KTLQEVTQLSQEAQRIVEKLEKSTKPIVAAING 143
            ||::::.....|.|||||     |..:.|   ..|.:.|:::           ::.|||:||:||
  Fly    88 SAIVLTGSEKAFAAGADIKEMVGNTYSQCIQGNFLNDWTEVA-----------RTQKPIIAAVNG 141

Human   144 SCLGGGLEVAISCQYRIATKDRKTVLGTPEVLLGALPGAGGTQRLPKMVGVPAALDMMLTGRSIR 208
            ..||||.|:|:.|.  |.....|...|.||:.||.:|||||||||.::||...|::|.|||..|.
  Fly   142 YALGGGCELAMMCD--IIYAGDKAKFGQPEIALGTIPGAGGTQRLTRVVGKSKAMEMCLTGNMIG 204

Human   209 ADRAKKMGLVDQLV---EPLGPGLKPPEE-----RTIEYLEEVAI------TFAKGL-------- 251
            |..|:|:||..::|   :.||..:|..|:     ..|..|.:.|:      |..:||
  Fly   205 AQEAEKLGLASKVVPADQLLGEAVKLGEKIGTHSNLIVQLCKEAVNTAYETTLQEGLKFERRTFH 269

Human   252 -----ADKKISPKRDKGLVEKLTAYAMTIP 276
                 ||:|          |.:||:|...|
  Fly   270 ATFSTADRK----------EGMTAFAEKRP 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HADHA	NP_000173.2	fa_ox_alpha_mit	27..762	CDD:131494	90/288 (31%)
Echs1	NP_610910.1	crotonase-like	37..294	CDD:474030	87/278 (31%)