DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jak2b and Src42A

DIOPT Version :9

Sequence 1:	NP_571162.1	Gene:	jak2b / 30298	ZFINID:	ZDB-GENE-980526-123	Length:	1126	Species:	Danio rerio
Sequence 2:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster

Alignment Length:	940	Identity:	204/940 - (21%)
Similarity:	331/940 - (35%)	Gaps:	334/940 - (35%)

- Green bases have known domain annotations that are detailed below.

Zfish   437 LITRSESGNYNLSGTKKSFRS--LQDLLKCYQKETVKSDGIVFQFSKCCSP---RPKEKSSLLVC 496
            ||.|..|..      :|||.|  |.......:::|.|.:         ||.   :|.::..|.||
  Fly   727 LIKRQNSRQ------RKSFASYFLPHRHSTKEQKTEKEN---------CSRDPIKPSQEQQLAVC 776

Zfish   497 RS---HRGLEVPLSSSLQRHNI---SQMVFHKI-----KKED----------------------- 527
            ..   ||.....:|||..|.|.   .::|:..|     :|.|
  Fly   777 GKLPLHRSNTSDISSSYYRRNFKIYDKLVYGTIYDIIQRKNDIYQKYDKYMTYGTIYEILHRKTS 841

Zfish   528 --------------LELGESQGQ--------------------------------GTFTKIFKGI 546
                          ||.|.|.|.                                ||...|.:|:
  Fly   842 QSSDPWQRKSLSSILEGGRSSGDIIYDIGQRRERDKRTLGSSSSATVSTINPHKYGTIYDILQGV 906

Zfish   547 RKEQGDYGE-------------THKTEVIVKVL---------DKAHRNYSESFFEAASMMSQLTH 589
            :.:.|....             ...|..:|..:         |::.::..|.....::..:::..
  Fly   907 KIDAGHVKNKPDQKSKPTKPPLAKPTRFVVSQVVEPVQIPPTDQSGKSVQEQGAPKSNKPNKMRR 971

Zfish   590 KHLVLTYGICVCGDENIMVQEYVKFGSLDTYLKKNKSSVSV---NILWKLE--------VAKQLA 643
            ...:|:|      ..|....:....|..:|..|:.::...:   |:|..|:        :|:|..
  Fly   972 LSNILSY------SRNSGEDQQETTGKEETKPKRTQAKRRIGVTNLLLPLDSEELYTRIIAQQRG 1030

Zfish   644 WAMLYL---EEKSLAHGNVCAKNILLIREEDRALGNTPFIKLSDPGISITV---------LPREI 696
            ....:.   |||..:...:|.:|.|           |....|....:|:.:         .||..
  Fly  1031 LDKEHSQEPEEKCASEEQMCTRNAL-----------TKSSSLDAISLSVAISPASSPSPPRPRRS 1084

Zfish   697 LVERIPWVPPECILDPKNLSLATD--------------------KWSFGTTLWEIC--SGGEQPL 739
            |.:.      .|:...:...||..                    :||..|.|...|  :..|.||
  Fly  1085 LKQH------RCLQQHQQTPLAKKHSLDNCLQVVSSTTSRQPLRRWSNQTPLKCTCHPATEELPL 1143

Zfish   740 ANMDNSKKHLFYENHHQLPAPKWTELANLINSC-----MDYEPTFRPSF---------KAIIRDL 790
            ..::.|:         .|||   ...|:..::|     :|..|.....|         |...|.|
  Fly  1144 TAIEKSR---------SLPA---ACSASCSHTCAHLSVIDQSPATTKCFGKTSLTTAKKGKSRRL 1196

Zfish   791 N-------------------------SLFCPDYE----IVKESDIMPSRAAASIFNTGTFKN--- 823
            :                         .|..|:.|    ::::|:...:..:.|:.:..|.|:
  Fly  1197 SEFTRGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRI 1261

Zfish   824 --------------------------------------------NEPV------------QFEER 832
                                                        .:||            :.:..
  Fly  1262 RQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRT 1326

Zfish   833 HLIFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTTEHIRDFEREIEILKSLQHENIVK 897
            .|.|:::||.|.||.|    ::.|.:|| ..||:|.|:..|.:. :||..|.:|:|.|:|..:::
  Fly  1327 SLKFVRKLGSGQFGDV----WEGLWNNT-TPVAIKTLKSGTMDP-KDFLAEAQIMKKLRHTKLIQ 1385

Zfish   898 YKGVCYGAGRRNLRLVMEYLPYGSLRDYL----NKNRDRIDHQKLVHYASQICKGMEYLATKRYI 958
            ...||  .....:.::.|.:.:|||.:||    .|.|. :..|.|:..|:||..||.||.::.||
  Fly  1386 LYAVC--TVEEPIYIITELMKHGSLLEYLQAIAGKGRS-LKMQTLIDMAAQIAAGMAYLESQNYI 1447

Zfish   959 HRDLATRNILVESECRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWHAPESLTESKFSVASDVW 1023
            |||||.||:||.....|||.||||.:::.:|:  |:.:.....||.|.|||:...||||:.||||
  Fly  1448 HRDLAARNVLVGDGNIVKIADFGLARLIKEDE--YEARVGARFPIKWTAPEAANYSKFSIKSDVW 1510

Zfish  1024 SFGVVLYELFTYSDKLCSPPTVFLSMVGGDKQGQTIVYHLIELLKRGNRLPQPMGCPTEMFEIMQ 1088
            |||::|.||.||. ::..|             |.|.. .::..::.|.|:|||..|...::|||.
  Fly  1511 SFGILLTELVTYG-RIPYP-------------GMTNA-EVLTQVEHGYRMPQPPNCEPRLYEIML 1560

Zfish  1089 ECWDNDPSLRPNFKELALRVDLIRDSSDAD 1118
            |||..||..||.|:.|..:::....|..:|
  Fly  1561 ECWHKDPMRRPTFETLQWKLEDFYTSDQSD 1590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jak2b	NP_571162.1	B41	29..262	CDD:214604
		FERM_B-lobe	144..253	CDD:271216
		FERM_C_JAK2	258..370	CDD:270141
		SH2_Jak2	370..466	CDD:198242	9/30 (30%)
		PKc_like	528..791	CDD:304357	59/375 (16%)
		Pkinase_Tyr	528..790	CDD:285015	59/374 (16%)
		PKc_like	829..1112	CDD:304357	105/286 (37%)
		TyrKc	834..1104	CDD:197581	104/273 (38%)
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	7/90 (8%)
		PTKc_Frk_like	1319..1587	CDD:270653	105/293 (36%)
		Pkinase_Tyr	1328..1580	CDD:285015	105/277 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910