DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment foxg1a and FoxK

DIOPT Version :9

Sequence 1:	NP_571142.1	Gene:	foxg1a / 30274	ZFINID:	ZDB-GENE-990415-267	Length:	420	Species:	Danio rerio
Sequence 2:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster

Alignment Length:	374	Identity:	103/374 - (27%)
Similarity:	153/374 - (40%)	Gaps:	106/374 - (28%)

- Green bases have known domain annotations that are detailed below.

Zfish    28 VQSDNHHHH---HH------QQQQH--------------HHRTVHEEEEK--------------- 54
            :|...|.||   ||      ||||.              ||..:|:::::
  Fly   309 LQQQQHPHHPPAHHLPLQQQQQQQQPAHHPLPHTPHHPLHHTALHQQQQRSGSIVVAPPAGAAAH 373

Zfish    55 ----------TPLPAQV--QEQKS-----------ENTCAKS-----------------DNSSHD 79
                      :||...:  :||||           .|:|..|                 :|::.|
  Fly   374 LIAGDGPGIYSPLKISIPKKEQKSPYLSPTGTISAANSCPASPRQGFIQNQPNNYNNYGNNNTQD 438

Zfish    80 SSSTDEKEKQEEKRDAKEGEGGKEGDKKNGKYEKPPFSYNALIMMAIRQSPEKRLTLNGIYEFIM 144
            ...|.........                   ||||:||..||:.||..:|:|:|||:|||.||:
  Fly   439 LFQTPSTASYNHN-------------------EKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIV 484

Zfish   145 KNFPYYR-ENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRR 208
            |::|||| |..:|||||||||||||:.|:||.|..|:||||::|.:||.|....|..:..|.|:|
  Fly   485 KHYPYYRKETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQR 549

Zfish   209 STTS-RAKLAFKRGARLTSTGLTFMDRAGSLY------WPMSPFLSLHHPRASSALSYNGASSAY 266
            |:.. |......|.|.::.:.:.....:..|.      .|.||.:||....|...:.|| :.:|:
  Fly   550 SSQGFRPPYGMPRSAPVSPSHMDNSRESSPLQDIVLQSAPGSPGMSLEQRAADPEIIYN-SQNAH 613

Zfish   267 PSHPMSYSTMLTQNSLGNNHSFPASNGLSVDRLVNGEIPYATHHLTAAA 315
            ............|....|::.:.:.:...|....:|.....||...:||
  Fly   614 QQQQQQQQQQQQQTLSNNSNQYSSGSPYYVTNQSSGVATPQTHVEGSAA 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
foxg1a	NP_571142.1	FH	113..201	CDD:214627	52/88 (59%)
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	51/86 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850