DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbx2b and bi

DIOPT Version :9

Sequence 1:	NP_571126.1	Gene:	tbx2b / 30253	ZFINID:	ZDB-GENE-990726-27	Length:	687	Species:	Danio rerio
Sequence 2:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster

Alignment Length:	842	Identity:	305/842 - (36%)
Similarity:	378/842 - (44%)	Gaps:	297/842 - (35%)

- Green bases have known domain annotations that are detailed below.

Zfish    12 AYHPFHAHRPTDFPMSAFLAAAQPSFFPALTLPPGA--LTKPIPDH------------------- 55
            |.||  :|.||....|....||.|        |.||  |..|.|.|
  Fly   191 AAHP--SHHPTAAHHSPSTGAAAP--------PAGATGLPPPTPPHHLQQQQQQQQHPAPPPPPY 245

Zfish    56 -------TLAGAAEAGLHPAL--------SHHHQAAH---------------------------- 77
                   .||| :.||.||.|        ..||..||
  Fly   246 FPAAALAALAG-SPAGPHPGLYPGGGLRFPPHHPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHP 309

Zfish    78 -LRSLKSLEPEEE-VEDDPKVTLEAKDLWDQFHKLGTEMVITKSGRRMFPPFKVRINGLDKKAKY 140
             :|.|::|:||:: |.||||||||.||||::|||||||||||||||:|||..|.|::|||.||||
  Fly   310 AMRPLRALQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKY 374

Zfish   141 ILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNIS 205
            |||:|||||||.||||||||||||||||||||||||||||||.||||||.|.|:|||||||||||
  Fly   375 ILLLDIVAADDYRYKFHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNIS 439

Zfish   206 DKHGF---TILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKIDN 267
            |||||   ||||||||||||||:|||||||||||||||||||.||:|||||||||:|||||||||
  Fly   440 DKHGFVSTTILNSMHKYQPRFHLVRANDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDN 504

Zfish   268 NPFAKGFRDTGNGRREKRKQLTLPSLRMYEDQCKVDRDGADSD-------ASSSEPTTGRDAGHS 325
            |||||||||||.|:|||::.|             :...|:|||       :||..|.....||..
  Fly   505 NPFAKGFRDTGAGKREKKQAL-------------MSNRGSDSDKLNPTHVSSSRAPLHLGHAGRP 556

Zfish   326 P-----------------------GPVSSPLRFNRGSRDDKTCTDSEHEMD-HQN--------DR 358
            |                       ||..|||         ...:.|..:|. ||:        :.
  Fly   557 PHLHPHAALLDNQQDDDDKLLDVVGPPQSPL---------LPLSHSLQQMHAHQHSAALAAWFNH 612

Zfish   359 CGGSSSPAPKPSSPFRSRSEDWGREKPIAEKKDDYPDSRKTSDSIFSIRNLEKDKLESRSRKDTD 423
            ..|:.:.|.:.::...:.:.                               .:|.|..|.:.|.|
  Fly   613 LAGAGAGASEHAAAAAANAS-------------------------------AEDALRRRLQADAD 646

Zfish   424 SSKKDTENS---GISGSKDSFSPLMVQTESPSHFGAGHLQSLALSGLHSQQFFNPLNTGQPLLFH 485
            ..:..:::|   .:.||..               ||                |.|.:||.|
  Fly   647 VERDGSDSSCSESVGGSTG---------------GA----------------FRPTSTGSP---- 676

Zfish   486 PGQFAMAPGAFSAMGMGHLLASVSGAGGLENGSLSAQGTGSTPSPF-----PFHLSQHMLASQGI 545
                ..|.||          |:.:.|.||..|.      ||.|||.     |.|.|.|:|
  Fly   677 ----KEAVGA----------AAAAAAAGLNPGG------GSYPSPNISVGPPIHPSPHLL----- 716

Zfish   546 PMPTFGGLFPYPYTYMAAAAAAASALPASSSTASSLSRNPFLSSSTRPRL--------------- 595
            |.....||:|.|:..:....|||:|:..:......|.......::..|.|
  Fly   717 PYLYPHGLYPPPHLGLLHNPAAAAAMSPAGLNPGLLFNAQLALAAQHPALFGHAYAAAGHTPVSP 781

Zfish   596 -------RFNPYQLPVSIPQSTNLLTT----------------GLPSGL---NPSSESSKCGSRE 634
                   ||:||.||.|:..:.:.:|.                ||..|:   .|.|.||....|.
  Fly   782 LQGLKSHRFSPYSLPGSLGSAFDAVTPGSNANRSGDPPGGGGGGLGGGVVENGPRSLSSSPRPRP 846

Zfish   635 ASPVPDHKSGASQRNGSPKTTMKE---------------SINELQNIQRLVSGLESQRETSS 681
            ||..|..:. .|....:|.:.||:               |.:||::::::|:|||.|...|:
  Fly   847 ASHSPPTRP-ISMSPTTPPSLMKQPRGGGAGAGVAQSQHSPSELKSMEKMVNGLEVQHNGSA 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbx2b	NP_571126.1	TBOX	95..278	CDD:238106	162/185 (88%)
		TBX	294..361	CDD:204975	19/105 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	303..452		29/190 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..687		25/105 (24%)
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	10/57 (18%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	159/182 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I1085
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	407	1.000	Inparanoid score	I1860
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002445
OrthoInspector	1	1.000	-	-		otm26063
orthoMCL	1	0.900	-	-		OOG6_105359
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	1	1.000	-	-		X1628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.850