DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sema3h and Sema1a

DIOPT Version :9

Sequence 1:	NP_001315307.1	Gene:	sema3h / 30252	ZFINID:	ZDB-GENE-990715-8	Length:	749	Species:	Danio rerio
Sequence 2:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster

Alignment Length:	665	Identity:	186/665 - (27%)
Similarity:	308/665 - (46%)	Gaps:	133/665 - (20%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MLALFCLMLLAAPLTDAWKSS-QPRLHFQ-----------HSELMRSGRLVSLSMPAGDLNSLLP 53
            |.....|.:|......||:.: :|:|:.:           :..::...:||:
  Fly    50 MQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFKLVT------------- 101

Zfish    54 DEDGRRLYIGMKDHLLSTSLDDITQNPRKIYWPANPDRIQDCTMAGKTLEMDCANFLRVLERYNQ 118
             :||..|.||.::.:.:.|:.|:.:..| :.|.:..|..:.|.:.||. |..|.|::|::...:.
  Fly   102 -KDGNSLLIGARNTVFNLSIHDLVEQQR-LVWTSPEDDTKMCLVKGKD-EEACQNYIRIMVVPSP 163

Zfish   119 THLYACGTGAFNPRCAFIPTNLFLRAEEQ-TLQDEDTESGRGKCPFDPHQRTATAIIDGELYAGI 182
            ..|:.|||.:|.|.|     |.::.::.. ||  |.|::|:..||:||...:.:.:.|.|||:|.
  Fly   164 GRLFVCGTNSFRPMC-----NTYIISDSNYTL--EATKNGQAVCPYDPRHNSTSVLADNELYSGT 221

Zfish   183 SSDFLSHDTAFIRSLGERHVIRTEQYDSTWLQGAEFVHVTAMSESDNEEDDKVYVFFTERAQEAE 247
            .:||...|....     |..::||||||..|....||       |...:.|.||.||.|.|.|..
  Fly   222 VADFSGSDPIIY-----REPLQTEQYDSLSLNAPNFV-------SSFTQGDFVYFFFRETAVEFI 274

Zfish   248 GAAGKVLYSRVARVCKNDIGGQRSLVNKWSTFQKARIVCSVPGPDGIQTHFDKLQD----IFIQH 308
            . .||.:|||||||||.|.||.....|:|::|.|:|:.||:||  ....:|:::|.    :..|:
  Fly   275 N-CGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPG--DYPFYFNEIQSASNLVEGQY 336

Zfish   309 GRDKKNPLVYGLFTTTSNVLNGSAVCVYRMQDIIRAFKGNFLHREG-HQYKLTEYTGRVPYPRPG 372
            | ...:.|:||:|.|.||.:.|||||.:.:|||...|:|.|..:.| :...|.....:||.||||
  Fly   337 G-SMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPG 400

Zfish   373 TCPSSTYGGFRSTREYPDDVIFFSRTHPLMQEVVRPLGGQPLLIRVGVPYKLTRLLVD-RVEAVD 436
            :|       ...:|..||..:.|.:||.||.|.|.....||:|:|....|:.|::.|| :::...
  Fly   401 SC-------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPG 458

Zfish   437 GQ-HDVMFIGTDSGLVLKVLHFPKANRQNQ--EVTLEQLQVFKHKSAITAMTLSKKKQW------ 492
            |: :||:|:|||.|.::|.::...|:..::  .|.:|::.|......|..:.:.:..|:
  Fly   459 GKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDG 523

Zfish   493 ------LFAGSAEGVVQLGLFQC--DLYGQACAECCLARDPYCTWD-------GHSCSQFM---- 538
                  |...:...||.:.|.:|  |.. .:|:||...:||||.||       .|...:::
  Fly   524 SYDDGKLIIVTDSQVVAIQLHRCHNDKI-TSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENY 587

Zfish   539 -------------PTGR--------------RRNI-----RQVNDDGNPLNQCVRQGAGLQVEAE 571
                         |:|:              |.::     |:.:.|...::...:...|.|:.|:
  Fly   588 FYQNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGPQISAD 652

Zfish   572 -------EKTLVVAV 579
                   .:|||:||
  Fly   653 IINAQYTVETLVMAV 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sema3h	NP_001315307.1	Sema_3	39..509	CDD:200500	153/491 (31%)
		PSI	508..>544	CDD:214655	14/75 (19%)
		Ig_Semaphorin_C	570..661	CDD:143180	6/17 (35%)
		IG_like	573..658	CDD:214653	5/7 (71%)
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	154/500 (31%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	12/34 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920