DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tnn and Ten-m

DIOPT Version :9

Sequence 1:	XP_005171321.1	Gene:	tnn / 30234	ZFINID:	ZDB-GENE-990415-262	Length:	1020	Species:	Danio rerio
Sequence 2:	NP_001262211.1	Gene:	Ten-m / 40464	FlyBaseID:	FBgn0004449	Length:	3349	Species:	Drosophila melanogaster

Alignment Length:	1184	Identity:	237/1184 - (20%)
Similarity:	374/1184 - (31%)	Gaps:	454/1184 - (38%)

- Green bases have known domain annotations that are detailed below.

Zfish   119 CAQGCC---KGGAGVDTS------------CSGHGTYQQDSCSCKCNPGWEGPDCSISSCPDECN 168
            ||.|.|   ||..|.|.:            ||||||:..|:.:|.|...|.|.|||...|..:|.
  Fly  1178 CADGTCICKKGWKGPDCATMDQDALQCLPDCSGHGTFDLDTQTCTCEAKWSGDDCSKELCDLDCG 1242

Zfish   169 DNGRCVDGRCVCYEGYTGHDCSQLTCPNDCKDKGHCVDGKCVCFSGFSGEDCSIATCPNDCIGNG 233
            .:|||....|.|...:.|..|:...|...|.:.|.|.:|.|:|.:|::|:.|:|..|||.|.|:|
  Fly  1243 QHGRCEGDACACDPEWGGEYCNTRLCDVRCNEHGQCKNGTCLCVTGWNGKHCTIEGCPNSCAGHG 1307

Zfish   234 RC-VDG----QCICDEGFFGIDCSMVL----GPKGLRLIKVTDVSLLVEWESVRGAEYYILSYHP 289
            :| |.|    :|.|.||:.|.||.:.|    |..     |..|...||:.|.......::.
  Fly  1308 QCRVSGEGQWECRCYEGWDGPDCGIALELNCGDS-----KDNDKDGLVDCEDPECCASHVC---- 1363

Zfish   290 KGNK---GAIKEVQVENTKNSYLITGLKPGVT--------YIV-----QVYAVIRGIN------- 331
            |.::   .|.|.:.|       |:....|.:|        :::     |.||.:...|
  Fly  1364 KTSQLCVSAPKPIDV-------LLRKQPPAITASFFERMKFLIDESSLQNYAKLETFNESIFWNY 1421

Zfish   332 ---SESDQITATTEVS---GIEGIKVLSQT---------EDS----------------------- 358
               |.|..|......|   |:.|::|.:.|         :|.
  Fly  1422 FNASRSAVIRGRVVTSLGMGLVGVRVSTTTLLEGFTLTRDDGWFDLMVNGGGAVTLQFGRAPFRP 1486

Zfish   359 ----IQVDWKNPGIIVDYFKLTHASHDGQG--------GHENVVMSQE--ARTKHTIVGLNPGTE 409
                :||.| |..:|:|...::.:...|..        .|:..:|...  |..||...|..|
  Fly  1487 QSRIVQVPW-NEVVIIDLVVMSMSEEKGLAVTTTHTCFAHDYDLMKPVVLASWKHGFQGACP--- 1547

Zfish   410 YQIGVQAIKGENEGKASFATGVTDIDAPTNLATREVTENSATVTWDGVRAEIDGYMLTY--SSAE 472
                                     |....||..:|.:.|..:...|:.       |.|  |.|.
  Fly  1548 -------------------------DRSAILAESQVIQESLQIPGTGLN-------LVYHSSRAA 1580

Zfish   473 GTSREIKVAAG----ATSYQLTSLK---------------PGVLYTVFLWAYKGSRSSRKSMTEA 518
            |....||:...    .||..|..|:               ||:.:|   :|:......|:.:...
  Fly  1581 GYLSTIKLQLTPDVIPTSLHLIHLRITIEGILFERIFEADPGIKFT---YAWNRLNIYRQRVYGV 1642

Zfish   519 ETDIDAPTNLMTREVTEDSASVTWNKVQADIDGYMLKYSSLDGSGQEVRVGADSTSYRFTGLKPG 583
            .|.:.......|     |...:.|:.....:.|:.:..|.:.|...::.       :|: ....|
  Fly  1643 TTAVVKVGYQYT-----DCTDIVWDIQTTKLSGHDMSISEVGGWNLDIH-------HRY-NFHEG 1694

Zfish   584 VLYTVYVWAIKGARSSKKSSTEAETDIDAPTNLLTQ---------EVTEDSASVTWNKVQADI-- 637
            :|.       ||..|:.....:       |..:||.         |..:.....|..::.|.:
  Fly  1695 ILQ-------KGDGSNIYLRNK-------PRIILTTMGDGHQRPLECPDCDGQATKQRLLAPVAL 1745

Zfish   638 ----DGYM-------LKYSSLDGSGQE-VRVGADSISYRF-TGLKP--GVLYT--------VSV- 678
                ||.:       ::....|||.:. |::.|..:|||: ..|.|  |.||.        :.|
  Fly  1746 AAAPDGSLFVGDFNYIRRIMTDGSIRTVVKLNATRVSYRYHMALSPLDGTLYVSDPESHQIIRVR 1810

Zfish   679 -----------W-AVKGSRSSRKATTEA---------ETEIDAPK----------------NLKA 706
                       | ||.||........||         :.::..||                |::.
  Fly  1811 DTNDYSQPELNWEAVVGSGERCLPGDEAHCGDGALAKDAKLAYPKGIAISSDNILYFADGTNIRM 1875

Zfish   707 TDVQTQTSTLT--------WK-----------------------APQAN----IEGYILTYRAED 736
            .|.....|||.        ||                       :|..|    |:.:::.....|
  Fly  1876 VDRDGIVSTLIGNHMHKSHWKPIPCEGTLKLEEMHLRWPTELAVSPMDNTLHIIDDHMILRMTPD 1940

Zfish   737 GSMQTV--------------------EKTL--------------------TARENRFALSG---- 757
            |.::.:                    ..||                    :.|.||..:.|
  Fly  1941 GRVRVISGRPLHCATASTAYDTDLATHATLVMPQSIAFGPLGELYVAESDSQRINRVRVIGTDGR 2005

Zfish   758 -------------LEMG------KKYIVTL------------------IAYRGSKRSKIVETTFS 785
                         ||.|      :.|:.|.                  ||.:.:.|.:.|.::..
  Fly  2006 IAPFAGAESKCNCLERGCDCFEAEHYLATSAKFNTIAALAVTPDSHVHIADQANYRIRSVMSSIP 2070

Zfish   786 TVGLAYQFPM---DCTQI---------MRNGNMESG----VYTIYVNNNRSRTMQVYCDMKTDGG 834
            ....:.::.:   |..:|         :...|:.:|    |:|..||.:..:...|     ||..
  Fly  2071 EASPSREYEIYAPDMQEIYIFNRFGQHVSTRNILTGETTYVFTYNVNTSNGKLSTV-----TDAA 2130

Zfish   835 GWIVFQRRN-TGKVDFMKKWRDYMKGFGELTEEFWLGLDKIHELTNTPTQYEARFDLG------- 891
            |..||..|: |.:|:.::..:      |:........:..:||| :||..|...::..
  Fly  2131 GNKVFLLRDYTSQVNSIENTK------GQKCRLRMTRMKMLHEL-STPDNYNVTYEYHGPTGLLR 2188

Zfish   892 ---SGSDRKYAV-YDNF-----KVAPSKQKFKLTIG-SYKG-------NA---------GDAMTY 930
               ..:.|.|.. ||.|     .|.|:.:..:|:.. |.||       ||         |..:..
  Fly  2189 TKLDSTGRSYVYNYDEFGRLTSAVTPTGRVIELSFDLSVKGAQVKVSENAQKEMSLLIQGATVIV 2253

Zfish   931 HQGAPFS--TVDSD 942
            ..||..|  |||.|
  Fly  2254 RNGAAESRTTVDMD 2267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tnn	XP_005171321.1	EGF_alliinase	<133..163	CDD:282688	14/41 (34%)
		EGF_2	161..189	CDD:285248	8/27 (30%)
		EGF_2	193..220	CDD:285248	9/26 (35%)
		EGF_2	224..251	CDD:285248	14/31 (45%)
		fn3	257..333	CDD:278470	16/101 (16%)
		fn3	344..426	CDD:278470	20/130 (15%)
		fn3	435..514	CDD:278470	22/99 (22%)
		fn3	523..602	CDD:278470	12/78 (15%)
		fn3	611..683	CDD:278470	25/118 (21%)
		fn3	699..773	CDD:278470	27/205 (13%)
		FReD	792..1003	CDD:238040	45/203 (22%)
Ten-m	NP_001262211.1	TNFRSF	1069..1198	CDD:304602	8/19 (42%)
		CRD2	1106..1151	CDD:276900
		EGF_2	1139..1162	CDD:285248
		Keratin_B2	1162..1330	CDD:279797	56/151 (37%)
		EGF_2	1167..1194	CDD:285248	7/15 (47%)
		DUF3844	1171..>1235	CDD:289707	22/56 (39%)
		EGF_2	<1272..1294	CDD:285248	8/21 (38%)
		NHL	1750..2065	CDD:302697	51/314 (16%)
		NHL repeat	1784..1830	CDD:271320	12/45 (27%)
		NHL repeat	1854..1888	CDD:271320	7/33 (21%)
		NHL repeat	1911..1950	CDD:271320	5/38 (13%)
		NHL repeat	1972..2005	CDD:271320	4/32 (13%)
		NHL repeat	2039..2065	CDD:271320	3/25 (12%)
		RHS_repeat	2183..2218	CDD:283287	7/34 (21%)
		RhsA	2347..3020	CDD:225750
		YD_repeat_2x	2795..2836	CDD:273728
		Rhs_assc_core	2905..2980	CDD:274730
		Tox-GHH	3193..3268	CDD:292269
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1225
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900