DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment egr2b and cbt

DIOPT Version :9

Sequence 1:	NP_571072.2	Gene:	egr2b / 30190	ZFINID:	ZDB-GENE-980526-283	Length:	412	Species:	Danio rerio
Sequence 2:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster

Alignment Length:	283	Identity:	81/283 - (28%)
Similarity:	115/283 - (40%)	Gaps:	69/283 - (24%)

- Green bases have known domain annotations that are detailed below.

Zfish   172 QDPSAFLSTSTCPISYPPPSYSSPKPNADSGLFPIIPDYAGFFQPPCQRDMQSMPDRKPFSCPLD 236
            ||.::..|||.|       |.||....:.|.:.|.:.|  .:.:....|:::...:||..:
  Fly   118 QDENSSSSTSCC-------SSSSNTNTSTSSVPPTVED--DYPEANVWRNLKFKMNRKRAA---- 169

Zfish   237 SFKLPPPLTPLNTIRNFTLGGPVPDGPRLPTAYTPQNLPLRPILRP------------------- 282
            ...|||..||...:....    .|..|    |...:...::|||.|
  Fly   170 EVALPPVQTPETPVAKLV----TPPAP----AECIKEEEIKPILTPIYVSPVASSASQLILLSTV 226

Zfish   283 --RKYPNRPSKTP------------------VHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHK 327
              ::.|....|||                  ...|.|.|....|.:.:.:|..|..|.|:|||.:
  Fly   227 AAQQSPTPVPKTPTMSEEKLTTRITAAQAAATRSRIYECSFPDCGKNYFKSSHLKAHQRVHTGER 291

Zfish   328 PFQCR--ICMRNFSRSDHLTTHIRTHTGEKPFACDFCGRKFARSDERKRHTKIHLRQK----ERK 386
            ||.|:  .|.:.|||||.|:.|.|||||||.|.|..|.:||.|||...:|.|.|.:.|    .|.
  Fly   292 PFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKRHNKDKANGVNRH 356

Zfish   387 SSSSSTGVSSSERGVATSICSSS 409
            .|.::...|:|   ||.|:|.:|
  Fly   357 VSLANNNTSAS---VAASLCDAS 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
egr2b	NP_571072.2	DUF3446	92..164	CDD:288757
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..299		9/68 (13%)
		COG5048	295..>357	CDD:227381	29/63 (46%)
		zf-C2H2	299..323	CDD:278523	7/23 (30%)
		C2H2 Zn finger	301..323	CDD:275368	6/21 (29%)
		zf-H2C2_2	315..340	CDD:290200	11/26 (42%)
		COG5048	327..>411	CDD:227381	39/89 (44%)
		C2H2 Zn finger	331..351	CDD:275368	10/21 (48%)
		zf-H2C2_2	343..368	CDD:290200	14/24 (58%)
		C2H2 Zn finger	359..379	CDD:275368	9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..412		13/43 (30%)
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	7/23 (30%)
		C2H2 Zn finger	265..287	CDD:275368	6/21 (29%)
		COG5048	<270..362	CDD:227381	40/91 (44%)
		zf-H2C2_2	279..306	CDD:290200	11/26 (42%)
		C2H2 Zn finger	295..317	CDD:275368	10/21 (48%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		zf-C2H2	323..345	CDD:278523	10/21 (48%)
		C2H2 Zn finger	325..345	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940