DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment copg2 and gammaCOP

DIOPT Version :9

Sequence 1:	NP_571069.1	Gene:	copg2 / 30187	ZFINID:	ZDB-GENE-000208-8	Length:	873	Species:	Danio rerio
Sequence 2:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	877	Identity:	529/877 - (60%)
Similarity:	668/877 - (76%)	Gaps:	14/877 - (1%)

- Green bases have known domain annotations that are detailed below.

Zfish     6 DKKDEESGSGSNPFQHLEKSAVLQEARIFNETPINPRRCLHILTKIIYLLNQGEHFGTTEATEAF 70
            :|.|||.|. ||.:|:|||::||||.|.|||||:|||:|:||||||:||:||||.....|||:.|
  Fly     7 EKDDEEDGP-SNAYQNLEKTSVLQETRTFNETPVNPRKCIHILTKILYLINQGEQLVAREATDCF 70

Zfish    71 FAMTRLFQSNDQTLRRMCYLTIKEMANISEDVIIVTSSLTKDMTGKEDVYRGPAIRALCRITDTT 135
            ||||:||||.|..||||.||.|||:::|:|||||||||||||||||||:||..||||||.|||.|
  Fly    71 FAMTKLFQSKDVVLRRMVYLGIKELSSIAEDVIIVTSSLTKDMTGKEDLYRAAAIRALCSITDNT 135

Zfish   136 MLQAIERYMKQAIVDKVPSVSSSALVSSLHMVKMSFDVVKRWVNEAQEAASSDNIMVQYHALGLL 200
            ||||:||||||.||||..:||.:||||||.:...:.||||||.||||||.:||||||||||||||
  Fly   136 MLQAVERYMKQCIVDKNAAVSCAALVSSLRLANTAGDVVKRWANEAQEALNSDNIMVQYHALGLL 200

Zfish   201 YHLRKNDRLAVTKMLNKFTKSGLKSPFAYCMMIRIASKLLEE----TEGGHDSPLFDFIESCLRN 261
            ||:||:|||||:|::||.|:..||||:|.||:||||.||:||    :|...|||||.|||||||:
  Fly   201 YHIRKSDRLAVSKLVNKLTRGSLKSPYAVCMLIRIACKLIEEEDIPSEELSDSPLFTFIESCLRH 265

Zfish   262 KHEMVVYEAASAIVHMPNCTARELAPAVSVLQLFCSSPKAALRYAAVRTLNKVAMKHPSAVTACN 326
            |.|||:||||.|||::.|...|.|:||.|:||||||||||.||:|||||||||||.||:|||.||
  Fly   266 KSEMVIYEAAHAIVNLKNTNPRMLSPAFSILQLFCSSPKATLRFAAVRTLNKVAMTHPAAVTTCN 330

Zfish   327 LDLENLITDSNRSIATLAITTLLKTGSESSVDRLMKQISSFVSEISDEFKVVVVQAISALCQKYP 391
            ||||.||||||||:||||||||||||:||||:|||||||:||:||||||||||||||.|||.|||
  Fly   331 LDLEGLITDSNRSVATLAITTLLKTGAESSVERLMKQISTFVAEISDEFKVVVVQAICALCTKYP 395

Zfish   392 RKHSVMMNFLSNMLRDDGGFEYKRAIVDCIISIIEENPESKETGLAHLCEFIEDCEHTVLATKIL 456
            |||:|:|||||.|||::||.|||.:|||.||:|||||.::||:||:|||||||||||..||.:||
  Fly   396 RKHTVLMNFLSGMLREEGGLEYKTSIVDTIITIIEENADAKESGLSHLCEFIEDCEHVSLAVRIL 460

Zfish   457 HLLGKEGPRTPTPSKYIRFIFNRVVLESEAVRAAAVSALAKFGAQNDDLLPSVLVLMQRCMMDSD 521
            ||||||||...|||||||||:|||:|||..||||||:|:|:|||....||.::|||:.||.||.|
  Fly   461 HLLGKEGPFAATPSKYIRFIYNRVILESPIVRAAAVTAMAQFGASCPALLSNILVLLGRCQMDPD 525

Zfish   522 DEVRDRATFYMNVLQQKQKALNAAYIFNGLSVSVLGLEKSLHQYTLEPSEKPFDMKTVPLA--TA 584
            ||||||||:|:::|..::..|...||....:.|:..|||||.::.....:..||:..||.|  ..
  Fly   526 DEVRDRATYYLSILNSERPELYKNYIIERENCSLALLEKSLVEHLNGDVDTRFDISIVPKAAIVK 590

Zfish   585 PITEHKTEIAPVATSKLPEKLAPSRQDIYQEQLSAIPEFQGLGPLFKSSEPVQLTEAETEYVVRC 649
            |:..:...:   .||..|.....:|::....:|:.:|..|.|||:.:|:.|:||||:||||.|:|
  Fly   591 PVIANDVML---VTSSAPRPPKITREEESAARLAQLPGIQVLGPIHRSTAPIQLTESETEYTVQC 652

Zfish   650 IKHTFANHMIFQFDCTNTLNDQLLQKVLVQMEPSESYEVLHYVPAANLPYSQPGSCYSLVRLPED 714
            |||.|..|::|||||.|||:||:|:.|.|::...|.:.....:|...|||:...:.:.:|..|.|
  Fly   653 IKHIFGQHVVFQFDCLNTLSDQILENVRVELTLPEGFTTRAVIPCPKLPYNDLQTTFVIVEFPPD 717

Zfish   715 DPTAVSCTFSCTMKYLVRDCDPNTGEPD-DDGYDDEYVLEDLEVTVADHIQKVLKPNFAAAWDEV 778
            ...::: ||..|::::|:|||||||||: ::||||||:|||||:||||.|||..|.||..:||..
  Fly   718 AANSIA-TFGATLRFVVKDCDPNTGEPESEEGYDDEYMLEDLELTVADQIQKTRKNNFQVSWDAA 781

Zfish   779 GDE--CEKEETFALATVRTLDEAVNNIVSFLGMQPCERSDKVPENKNSHVLFLAGVFRGGHDVLV 841
            ..|  .:.|:||.|:.|.||.:|||.||..||:.....|:.|||..:.|.|..:|.||||.::||
  Fly   782 DSEEWLQAEDTFVLSAVTTLQDAVNTIVKILGLGAANLSENVPEGTHLHTLLCSGTFRGGAEILV 846

Zfish   842 RARLALADGVTMQVTVRSTDDNVVDVILASVG 873
            ||:|||::|||:.:||||||.:|.::|.|::|
  Fly   847 RAKLALSEGVTLNLTVRSTDQDVAELITAAIG 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
copg2	NP_571069.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		7/14 (50%)
		SEC21	7..868	CDD:227565	526/869 (61%)
		HEAT 1	64..101		23/36 (64%)
		HEAT 2	283..320		29/36 (81%)
		HEAT repeat	288..313	CDD:293787	20/24 (83%)
		HEAT 3	321..355		29/33 (88%)
		HEAT repeat	323..354	CDD:293787	27/30 (90%)
		UNC45-central	325..497	CDD:288539	135/171 (79%)
		HEAT 4	356..392		30/35 (86%)
		HEAT repeat	357..385	CDD:293787	24/27 (89%)
		HEAT 5	395..430		24/34 (71%)
		HEAT repeat	398..423	CDD:293787	17/24 (71%)
		HEAT repeat	435..461	CDD:293787	20/25 (80%)
		HEAT 6	467..504		26/36 (72%)
		HEAT repeat	471..501	CDD:293787	22/29 (76%)
		COP-gamma_platf	615..758	CDD:285908	68/143 (48%)
		Coatomer_g_Cpla	760..872	CDD:292991	55/113 (49%)
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	526/870 (60%)
		HEAT repeat	402..427	CDD:293787	17/24 (71%)
		HEAT repeat	439..465	CDD:293787	20/25 (80%)
		HEAT repeat	475..505	CDD:293787	22/29 (76%)
		HEAT repeat	512..538	CDD:293787	17/25 (68%)
		COP-gamma_platf	620..761	CDD:285908	68/141 (48%)
		Coatomer_g_Cpla	763..877	CDD:292991	55/113 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578715
Domainoid	1	1.000	738	1.000	Domainoid score	I102
eggNOG	1	0.900	-	-		E1_COG5240
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56292
Inparanoid	1	1.050	1025	1.000	Inparanoid score	I274
OMA	1	1.010	-	-		QHG53896
OrthoDB	1	1.010	-	-		D207992at33208
OrthoFinder	1	1.000	-	-		FOG0002163
OrthoInspector	1	1.000	-	-		oto41586
orthoMCL	1	0.900	-	-		OOG6_101348
Panther	1	1.100	-	-	LDO	PTHR10261
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R230
SonicParanoid	1	1.000	-	-		X1625
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.300