DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment acvr1ba and sax

DIOPT Version :9

Sequence 1:	XP_005162281.1	Gene:	acvr1ba / 30183	ZFINID:	ZDB-GENE-980526-527	Length:	519	Species:	Danio rerio
Sequence 2:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	230/525 - (43%)
Similarity:	306/525 - (58%)	Gaps:	69/525 - (13%)

- Green bases have known domain annotations that are detailed below.

Zfish    36 CTACE-------STGYVCETDGACMASTSYINGQEEQQVRICIPRVSLVPPGQPIYC----LSAK 89
            |.:||       ...:.|:....|..|.:.....:.|:.|.|    |..|...|:.|    |...
  Fly    79 CYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGC----STSPDQLPMICSQNSLKIN 139

Zfish    90 G--------LLNTHCCYTDFCNSINLQ--IPNGSS-----TGQTQYLSNVWGIADGKGGSWGPVE 139
            |        .:|..||..|:||..:..  :|..|:     |..|..:|.:
  Fly   140 GPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISKM--------------- 189

Zfish   140 LVAVIAGPVFLFCLLLIVGVLLFQHHQRNYNHRQRLDV----EDPSCDHLYL----------AKD 190
            ||||: ||..:..||..|.:...:.     :||:||..    :||..   ||          |.|
  Fly   190 LVAVL-GPFLVIALLGAVTIFFIRR-----SHRKRLAASRTKQDPEA---YLVNDELLRATSAGD 245

Zfish   191 KTLQDLIFDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREE 255
            .||::.:....||||||||||.||||:|:.:.|.|.||:|::||||||.|.|..:|||||.||:|
  Fly   246 STLREYLQHSVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDE 310

Zfish   256 RSWFREAEIYQTIMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNHYSVTIEGMIK 320
            .||.||.|||.||:||||||||||.:|.....:.|||||::.|:..|||||:||..:::...|:.
  Fly   311 ESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVW 375

Zfish   321 LSLSAASGLAHLHMEILGTQGKPGIAHRDLKSKNILVKKNGTCAIADLGLAVRHESITDTIDIAP 385
            :.||.|:||.|||.||.|.||||.:||||||||||||..||:|.|||.||||.|..:|..:|:..
  Fly   376 ICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGN 440

Zfish   386 NQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNAGGIHEDYQLPYYDLVPS 450
            |.:||||||||||||||:|:::.|::.:..||||.|||.||:.||..:.||.|:|::|:||:||.
  Fly   441 NPKVGTKRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPM 505

Zfish   451 DPSIEEMRKVVCDQRLRPNVPNWWQSYEALRVMGKIMRECWYANGAARLTALRIKKTLSQL-SVQ 514
            |||.|:||||||....||::||.|.|...:..|.|:|:|||:.|...||.|||||||:.:| |..
  Fly   506 DPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASAD 570

Zfish   515 EDIKI 519
            |.|::
  Fly   571 EKIRL 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
acvr1ba	XP_005162281.1	Activin_recp	32..105	CDD:279413	21/87 (24%)
		TGF_beta_GS	192..219	CDD:285687	16/26 (62%)
		S_TKc	223..506	CDD:214567	161/282 (57%)
		STKc_TGFbR1_ACVR1b_ACVR1c	225..512	CDD:271045	164/287 (57%)
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	21/92 (23%)
		TM_EGFR-like	182..218	CDD:213052	13/56 (23%)
		TGF_beta_GS	247..274	CDD:285687	16/26 (62%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	167/296 (56%)
		TyrKc	276..553	CDD:197581	155/276 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820