DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment acvr1ba and tkv

DIOPT Version :9

Sequence 1:	XP_005162281.1	Gene:	acvr1ba / 30183	ZFINID:	ZDB-GENE-980526-527	Length:	519	Species:	Danio rerio
Sequence 2:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	230/531 - (43%)
Similarity:	311/531 - (58%)	Gaps:	78/531 - (14%)

- Green bases have known domain annotations that are detailed below.

Zfish    31 ALKCNCT-ACE---STGYVCET--DGACMASTSYINGQ-----EEQQVRICIP----------RV 74
            :|.|.|. :|.   |.| .|||  .|:|.::...:..:     ||::...|:|          :|
  Fly    80 SLTCYCDGSCPDNVSNG-TCETRPGGSCFSAVQQLYDETTGMYEEERTYGCMPPEDNGGFLMCKV 143

Zfish    75 SLVP--PGQPIYCLSAKGLLNTHCCYTDFCN---------SINLQIPNGSSTGQTQYLSNVWGIA 128
            :.||  .|:.|.|          |...||||         .:....|:...:.::.:...|:|
  Fly   144 AAVPHLHGKNIVC----------CDKEDFCNRDLYPTYTPKLTTPAPDLPVSSESLHTLAVFG-- 196

Zfish   129 DGKGGSWGPVELVAVIAGPVFLFCLLLIVGVLLFQHHQRNYNHRQRLDVEDPSCDHLYLAKDKTL 193
                         ::|   :.|...:|||..|.|     .|..|::|..:....:.:..::...|
  Fly   197 -------------SII---ISLSVFMLIVASLCF-----TYKRREKLRKQPRLINSMCNSQLSPL 240

Zfish   194 QDLIFDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSW 258
            ..|:  ..:|||||||||.||||:|:.|.:..::||||:||||..:||...||||.|.:.||.||
  Fly   241 SQLV--EQSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASW 303

Zfish   259 FREAEIYQTIMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNHYSVTIEGMIKLSL 323
            |||.|||||:::||:|||||||||.|.||:|||:.|::||||.|||.|||:...:..:.:..|:.
  Fly   304 FRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAF 368

Zfish   324 SAASGLAHLHMEILGTQGKPGIAHRDLKSKNILVKKNGTCAIADLGLAVRHESITDTIDIAPNQR 388
            |.||||||||.||.||.|||.|||||:||||||||:||.|||||.||||::.|..|.|.||.|.|
  Fly   369 SLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPR 433

Zfish   389 VGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRC--NAGGIH----EDYQLPYYDL 447
            |||:||||||||.:.::.|.|:.||.||:|::|||.||:.|||  ...|..    |||.|||:|:
  Fly   434 VGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDV 498

Zfish   448 VPSDPSIEEMRKVVCDQRLRPNVPNWWQSYEALRVMGKIMRECWYANGAARLTALRIKKTLSQLS 512
            |||||:.|:|..|||.:..||.:|:.||..:.|..:.|||:|||:.|...||||||:||||.:|.
  Fly   499 VPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRLE 563

Zfish   513 ----VQEDIKI 519
                :...|||
  Fly   564 TDCLIDVPIKI 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
acvr1ba	XP_005162281.1	Activin_recp	32..105	CDD:279413	26/104 (25%)
		TGF_beta_GS	192..219	CDD:285687	15/26 (58%)
		S_TKc	223..506	CDD:214567	166/288 (58%)
		STKc_TGFbR1_ACVR1b_ACVR1c	225..512	CDD:271045	170/292 (58%)
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	26/100 (26%)
		GS	238..266	CDD:197743	16/29 (55%)
		S_TKc	267..557	CDD:214567	166/289 (57%)
		STKc_BMPR1	270..562	CDD:271046	170/291 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577725
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750