DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment desma and LamC

DIOPT Version :9

Sequence 1:	NP_001315305.1	Gene:	desma / 30148	ZFINID:	ZDB-GENE-980526-221	Length:	488	Species:	Danio rerio
Sequence 2:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster

Alignment Length:	477	Identity:	139/477 - (29%)
Similarity:	227/477 - (47%)	Gaps:	86/477 - (18%)

- Green bases have known domain annotations that are detailed below.

Zfish    62 RASGSFG-GGSVVRSYAGLGEKLDFNLADAINQDFLNTRTNEKAELQHLNDRFASYIEKVRFLEQ 125
            |||.|.. ||:...|..|         |.:.......:|..||.||||||||.|.||:::|.||.
  Fly    14 RASTSTPVGGASTSSRVG---------ATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLEN 69

Zfish   126 QNSALTVEIERLR---GREPTRIAELYEEEMRELRRQVEALTNQRSRVEIERDNLVDDLQKLKLR 187
            :||.||.|:...:   .||.:.:..:||:|:...|:.::....:::::||:...|.::...||.|
  Fly    70 ENSRLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPR 134

Zfish   188 LQEEIHQKEEAENN------------------------------------------LSAFRADVD 210
            |.::..:...||||                                          |...|..::
  Fly   135 LDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLDDLRKQLE 199

Zfish   211 AATLARLDLERRIEGLHEEIAFLRKIHEEEIRELQNQMQESQVQIQMDMSK---PDLTAALRDIR 272
            |.||||:|||.:.:.|.||:||..::|.:|:.|.:::.|....:|...:|:   ..|..:|:::|
  Fly   200 AETLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEAKLQQSLQELR 264

Zfish   273 LQYEAIAAKNISEAEDWYKSKVSDLNQAVNKNNEALREAKQETMQFRHQLQSYTCEIDSLKGTNE 337
            .|||.....|..|.|..|.:::.:|..|.|:..:....|.:|....|.::.....::.:|:.||.
  Fly   265 DQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNA 329

Zfish   338 SLRRQMSEMEERLGREAGGYQDTIARLEAEIAKMKDEMARHLREYQDLLNVKMALDVEIATYRKL 402
            .|..::.|:|..|..|...:...||.||||:.:|:||||..|:|||.|:::|::||:|||.|.||
  Fly   330 GLNARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKL 394

Zfish   403 LEGEESRISLPVQSFSSLSFRESSPEQHHHQQQQPQRSSEVHSKKTVLIKTIETRDGET-----R 462
            |.|||.|:::            .||       .:|...|.:.|..:.|..:..:|.|..     |
  Fly   395 LCGEERRLNI------------ESP-------GRPTTDSGISSNGSHLTASASSRSGRVTPSGRR 440

Zfish   463 TTSEGMSALSA----QRVVSES 480
            :.:.|:|..||    :.|:.||
  Fly   441 SATPGISGSSAVKRRRTVIDES 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
desma	NP_001315305.1	Filament_head	15..100	CDD:282575	9/38 (24%)
		Filament	101..409	CDD:278467	112/355 (32%)
		Mis14	<118..204	CDD:285804	26/130 (20%)
LamC	NP_001260974.1	Filament	45..401	CDD:278467	112/355 (32%)
		ATP-synt_B	<67..>142	CDD:304375	20/74 (27%)
		MreC	<178..>224	CDD:302802	15/45 (33%)
		LTD	473..574	CDD:279300
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0977
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810