DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment flt4 and htl

DIOPT Version :9

Sequence 1:	NP_571020.2	Gene:	flt4 / 30121	ZFINID:	ZDB-GENE-980526-326	Length:	1368	Species:	Danio rerio
Sequence 2:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	692	Identity:	224/692 - (32%)
Similarity:	322/692 - (46%)	Gaps:	152/692 - (21%)

- Green bases have known domain annotations that are detailed below.

Zfish   578 YVTTIPEGFDIEMEPSEDPLEQDLVQLKCNADNFTYENLRWYRLDPQTVPPELDCKSLHQYATFL 642
            ::.|.|.|              .|:.|.|:|......|:.|||               :....:.
  Fly   111 FLQTRPSG--------------SLLTLNCHALGNPEPNITWYR---------------NGTVDWT 146

Zfish   643 EGQLSFQTTSNNWVLQLNITNIQLQDEGNYVCEVQNRRTGVKHCHRKYIPVKAMEAPRYRHNPTN 707
            .|..|.:  .|.|.|.:.  ::...|.|||.|:|.|....::|..:..:..:....|.....|.|
  Fly   147 RGYGSLK--RNRWTLTME--DLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTGPLN 207

Zfish   708 HTVNVSESLQMNCDVEGTPFPQLSWFKDNQPLHQIS------GILLQDSNRTLSIQRVREEDAGL 766
            .|:.|:.:..|:|........:.:|.  ..|.|.::      .|:.:|.:: |....||.|..|.
  Fly   208 LTLVVNSTGSMHCKYLSDLTSKKAWI--FVPCHGMTNCSNNRSIIAEDKDQ-LDFVNVRMEQEGW 269

Zfish   767 YTCSACNQKGCVQSSATVSVI------------GSDDKTNVEIVILIGTGVIAIFF--------- 810
            |||...|..|...|:|.:.|:            ||...|:...:.:.| |:|.||.
  Fly   270 YTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFG-GLIFIFMTTLFVFYAI 333

Zfish   811 ------------------WVLLLVIFCNVKRVNPADIKTGYLSIIMDPGEVPLEEQ--------- 848
                              |...::||   |.....| .:|.:..::.| .|.:::|
  Fly   334 RKMKHEKVLKQRIETVHQWTKKVIIF---KPEGGGD-SSGSMDTMIMP-VVRIQKQRTTVLQNGN 393

Zfish   849 -----CEY-LPYDSSQWEISRDRLRLGKVLGHGAFGKVIEASIFGHDKKSSANTVAVKMLKEGAT 907
                 .|| .|.||: ||:.|..|.||..||.||||:|:.|.:       :...|||||:|||.|
  Fly   394 EPAPFNEYEFPLDSN-WELPRSHLVLGATLGEGAFGRVVMAEV-------NNAIVAVKMVKEGHT 450

Zfish   908 ASEHKALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEYCKYGNLSNFLRAKREFFLPYRD 972
            ..:..:|:.|::::..||.|:|::||||.|:: ||||.|||||..:|||.:||...|.|   .||
  Fly   451 DDDIASLVREMEVMKIIGRHINIINLLGCCSQ-NGPLYVIVEYAPHGNLKDFLYKNRPF---GRD 511

Zfish   973 RSPKTQSQVRRMIEAGQASQSEHQPSTSSTNPPRVTVDDLWKTPLTIEDLICYSFQVARGMEFLA 1037
            :                 .:...||..|   ||...:        |.:|||.::.|:||||::||
  Fly   512 Q-----------------DRDSSQPPPS---PPAHVI--------TEKDLIKFAHQIARGMDYLA 548

Zfish  1038 SRKCIHRDLAARNILLSENNVVKICDFGLARDIYKDPDYVRKG-NARLPLKWMAPESIFDKVYTS 1101
            ||:||||||||||:|:|::.|:||.|||||||| :..||.||. |.|||:|||||||:.:|.|.|
  Fly   549 SRRCIHRDLAARNVLVSDDYVLKIADFGLARDI-QSTDYYRKNTNGRLPIKWMAPESLQEKFYDS 612

Zfish  1102 QSDVWSFGVLLWEIFSLGASPYPGIQIDEDFCKRLKDGTRMRAPDNASPEIYGIMLACWQGEPRE 1166
            :|||||:|:|||||.:.|..|||.|...|:....|..|.||..|...|..||.:|..||.....:
  Fly   613 KSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADD 677

Zfish  1167 RPTFPALVEILGDLLQ--ENSLP------EIPFNVSQSSEDD 1200
            ||.|..:||.:..|||  |:.|.      :.|.:.|...||:
  Fly   678 RPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPPSTSDEEEDE 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
flt4	NP_571020.2	IG_like	258..348	CDD:214653
		Ig1_VEGFR	265..350	CDD:143270
		IG_like	362..445	CDD:214653
		Ig	373..445	CDD:299845
		Ig	602..685	CDD:143165	19/82 (23%)
		IG	602..678	CDD:214652	18/75 (24%)
		I-set	705..786	CDD:254352	23/86 (27%)
		IGc2	714..776	CDD:197706	16/67 (24%)
		PKc_like	858..1184	CDD:304357	147/328 (45%)
		Pkinase_Tyr	866..1177	CDD:285015	141/311 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	978..1007		5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1190..1212		4/11 (36%)
htl	NP_524394.2	Ig	112..191	CDD:299845	24/111 (22%)
		IG_like	113..191	CDD:214653	24/110 (22%)
		IG_like	205..289	CDD:214653	23/86 (27%)
		PKc_like	404..692	CDD:304357	147/328 (45%)
		STYKc	416..688	CDD:214568	141/311 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910