DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frzb and Corin

DIOPT Version :9

Sequence 1:	NP_571018.1	Gene:	frzb / 30119	ZFINID:	ZDB-GENE-990715-1	Length:	315	Species:	Danio rerio
Sequence 2:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster

Alignment Length:	298	Identity:	64/298 - (21%)
Similarity:	112/298 - (37%)	Gaps:	79/298 - (26%)

- Green bases have known domain annotations that are detailed below.

Zfish    30 SCEPIRIPMCK--SMPWNMTKMPNHLHHSTQANAVLAIEQFEGLLGTQCSADLLFFLCAMYAPIC 92
            :|.||.:..|:  .:|:|.|..||::.|..|......::.:|.|:..:|...:..|||.::.|.|
  Fly   778 TCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKC 842

Zfish    93 TIDFQHDPIKPCKSVCERAKCGCEPVMKRYNHTWPESLAC---EELPVYDRGVCISP--EAIVKA 152
              ......:.|||::|......|......:..:.||.|.|   ::.|..:..|.:..  |.:..|
  Fly   843 --GQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVREVMRAA 905

Zfish   153 EGPDNSYYQ-DPAKCNPEGNPDFPMDSHNTNCKGANDRCKCKSVKFNQKTYSKNNYNYVIRARVK 216
            ..|....:| |..:|.|:   ::..|.| .:|....|..||:                  |....
  Fly   906 THPKCDGFQCDQNRCLPQ---EYVCDGH-LDCMDQADEAKCE------------------RCGPD 948

Zfish   217 EIRIRNHDLSAIVEVKEVLKSSLVNIPRDTVTLYYNSGCL-CPPLTANDEYIIMGYENEERSRLL 280
            ||...:   |..:..|.:.                 .|.: ||            |..:||:.|.
  Fly   949 EIYCGD---SQCIGTKHIC-----------------DGIIDCP------------YGQDERNCLR 981

Zfish   281 LIDRS------IAQKWKEKIGRK------VKRWDQAAN 306
            |.:|:      :.:.:  :||::      ||.||:|.:
  Fly   982 LSERNGDVGTGVLEVY--RIGQRQWMPACVKNWDRAVS 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frzb	NP_571018.1	CRD_SFRP3	28..153	CDD:143550	31/129 (24%)
frzb	NP_571018.1	NTR_Sfrp3_like	200..310	CDD:239636	21/120 (18%)
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	29/117 (25%)
		LDLa	911..942	CDD:238060	8/34 (24%)
		LDLa	945..979	CDD:238060	10/65 (15%)
		SR	980..>1034	CDD:214555	10/40 (25%)
		SRCR	992..1086	CDD:278931	7/28 (25%)
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900