DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Znrf4 and HRD1

DIOPT Version :9

Sequence 1:	NP_001020049.1	Gene:	Znrf4 / 301127	RGDID:	1563631	Length:	327	Species:	Rattus norvegicus
Sequence 2:	NP_014630.1	Gene:	HRD1 / 854149	SGDID:	S000005373	Length:	551	Species:	Saccharomyces cerevisiae

Alignment Length:	259	Identity:	53/259 - (20%)
Similarity:	87/259 - (33%)	Gaps:	69/259 - (26%)

- Green bases have known domain annotations that are detailed below.

  Rat   124 EVTVRCDQSARVLLPHGEPCPEPECHPVVAASWALARAL---------ALAASTLFVLR------ 173
            |.||..|||..||....:...:......:...:...:|:         ||..|.|...|
Yeast   236 ENTVESDQSQPVLNDDDDDDDDDRQFTGLEGKFMYEKAIDVFTRFLKTALHLSMLIPFRMPMMLL 300

  Rat   174 ---------------QLWPWVRGWGSRGTAVKTQTCQKAQVRTFTRLSDLCAICLDDY------- 216
                           .||...|........:.|.|.:  |::......::|.||:|:.
Yeast   301 KDVVWDILALYQSGTSLWKIWRNNKQLDDTLVTVTVE--QLQNSANDDNICIICMDELIHSPNQQ 363

  Rat   217 ---EEGERLKILPCAHAYHCRCIDPWFSRAARRSCPLCKQSV------------ASTHDGSTDGS 266
               .:.::.|.|||.|..|..|:..|..|:  ::||:|:..|            .|..|.:|..:
Yeast   364 TWKNKNKKPKRLPCGHILHLSCLKNWMERS--QTCPICRLPVFDEKGNVVQTTFTSNSDITTQTT 426

  Rat   267 I---GGDEAPLPGHRPPIWAIQARLRSRRLELLARTVPCRRCNSTTSLGMAENVAPSEATPEPS 327
            :   .|......|....:..:..|..|..:    |.||.:..:   :|.|...   |.:||.|:
Yeast   427 VTDSTGIATDQQGFANEVDLLPTRTTSPDI----RIVPTQNID---TLAMRTR---STSTPSPT 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Znrf4	NP_001020049.1	Peptidases_S8_S53	31..>93	CDD:299169
Znrf4	NP_001020049.1	zf-RING_2	207..252	CDD:290367	15/54 (28%)
HRD1	NP_014630.1	HRD1	5..551	CDD:227568	53/259 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910