DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Znrf4 and znrf3

DIOPT Version :9

Sequence 1:	NP_001020049.1	Gene:	Znrf4 / 301127	RGDID:	1563631	Length:	327	Species:	Rattus norvegicus
Sequence 2:	NP_001072864.1	Gene:	znrf3 / 780325	XenbaseID:	XB-GENE-5937936	Length:	853	Species:	Xenopus tropicalis

Alignment Length:	408	Identity:	90/408 - (22%)
Similarity:	142/408 - (34%)	Gaps:	129/408 - (31%)

- Green bases have known domain annotations that are detailed below.

  Rat    12 LALVALWLVLSLSPTDA--------QVNL----SSGDFLDLPALL-------GVPVDPKRARGYL 57
            |.||.||::|:::|.::        :|.|    .:||:......|       |..:.   |.|.:
Frog    10 LPLVWLWVLLAVAPGESLAKETAFVEVVLFESSPNGDYKTHTTELQGRFSRAGATIS---AEGEI 71

  Rat    58 LVARPADAC----------------LAIEGPGLDNRSLDPLVLVQPLGCSWEHTGRRARRARATA 106
            :...|...|                :.:|.|     .:||...:..||     ..:||.:..|||
Frog    72 VQMHPLGLCNNNDEEDLYEYGWVGVVKLEQP-----EMDPKPCLTVLG-----KAKRAVQRGATA 126

  Rat   107 ----ASMGSEAPGQL-RVFED----------------LEVTVRCDQSARVLLPHGEPCPEPECHP 150
                .|...:|..|| :..||                |...|...:.||..:.|..|....|...
Frog   127 VIFDVSDNPDAVEQLNQGLEDPLKRPVVYMKGMDAIKLMNIVNKQKGARARIQHRPPRQPTEYFD 191

  Rat   151 --VVAASWALARALALAASTLFVLRQLWPWVRGWGSRGTAVKTQTCQKAQVRTF----------- 202
              :..|.:.:...:.|.......|:|     |...:....:..|..:|.:.|.|
Frog   192 MGIFLAFFVVVSLVCLILLIKIKLKQ-----RRSQNSMNRMAVQALEKMETRKFKAKGKVPREGS 251

  Rat   203 ---------TRLSDLCAICLDDYEEGERLKILPCAHAYHCRCIDPWFSRAARRSCPLCKQSVAST 258
                     :..|| |||||:.|.:||.|:::||.|.:|.||:|||..:  ..:||.|:.::...
Frog   252 CGGLDTLSSSSTSD-CAICLEKYIDGEELRVIPCTHRFHKRCVDPWLLQ--NHTCPHCRHNIIEQ 313

  Rat   259 HDGSTDGSIGGDEAPLPGHRPPIWAIQARLRSRRLE------------LLARTVPCRRCNSTTSL 311
            ..|              || .|:....:..|.|:.:            .:.||.|.....:.||:
Frog   314 KKG--------------GH-GPVCVENSSNRGRQQQQQRVILPVHYPGRVQRTGPIAAYPTRTSM 363

  Rat   312 GMAEN---VAPSEATPEP 326
            |...|   |...|...||
Frog   364 GPHGNPITVLTVERPLEP 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Znrf4	NP_001020049.1	Peptidases_S8_S53	31..>93	CDD:299169	15/88 (17%)
Znrf4	NP_001020049.1	zf-RING_2	207..252	CDD:290367	21/44 (48%)
znrf3	NP_001072864.1	ZNRF_3_ecto	74..180	CDD:375639	23/115 (20%)
		RING-H2_ZNRF3	266..309	CDD:319713	21/44 (48%)
		RING-H2 finger (C3H2C3-type)	266..306	CDD:319713	20/41 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	583..629
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	650..673
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..713
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..853
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920