DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Znrf4 and rnf43

DIOPT Version :9

Sequence 1:	NP_001020049.1	Gene:	Znrf4 / 301127	RGDID:	1563631	Length:	327	Species:	Rattus norvegicus
Sequence 2:	XP_002935238.2	Gene:	rnf43 / 100491274	XenbaseID:	XB-GENE-952685	Length:	689	Species:	Xenopus tropicalis

Alignment Length:	375	Identity:	90/375 - (24%)
Similarity:	130/375 - (34%)	Gaps:	128/375 - (34%)

- Green bases have known domain annotations that are detailed below.

  Rat    10 APLALVALWLVLSLS----------------------PTDAQVNLSSG---DFLDLPALLGVPVD 49
            |.|.|.:|||:|:::                      .|..|...|.|   ..|.|..|.....:
Frog     4 ARLQLASLWLLLTVTLQAVASAMGTTEREMDVKALIRVTPLQAEESGGVGQGNLTLEGLFARVAE 68

  Rat    50 PKRARGYLLVARPADACLAIEG----PGL--------DNRSLDPLVLVQPLGCSWEHTGRRARRA 102
            ...|.|.||...|...|...|.    ||.        .:|...|.:.:             |.:|
Frog    69 ISPAEGRLLQFHPLSLCNTSEDDQTKPGFISIVKLETPDRDTQPCLSL-------------ANKA 120

  Rat   103 RATAASMGSEA--------PGQLRVF------------------EDLEVTVRCDQSARVLLPHGE 141
            | .|...|:.|        .|.|:..                  |.|...|..::.|.|.:...|
Frog   121 R-LAGERGAHAVLFDITNDRGALQQLQQPAGINQPVVLIWGPDAEKLMDVVNKNKEALVKIEVQE 184

  Rat   142 PCPEPECHPV-----VAAS------WALARAL--------ALAASTLFVLRQLWPWVRGWGSR-- 185
            . |:...|.:     ||.:      :|:||.|        ::...||..:.:|       |:|
Frog   185 Q-PKWLHHDIWILLTVAGTVMFFVLYAVARLLCRQPPPQDSIQQQTLLAISRL-------GTRRY 241

  Rat   186 -GTAVKTQTCQKAQVRTFTRLSD--LCAICLDDYEEGERLKILPCAHAYHCRCIDPWFSRAARRS 247
             ...:|.|......|.|.:..|.  :|||||:::.:|:.|:||||.|.||..|:|||..:  ..:
Frog   242 QQRMLKDQRASGGWVETASTSSSVPVCAICLEEFTDGQELRILPCCHEYHLGCVDPWLRQ--NHT 304

  Rat   248 CPLCKQSVASTHDGSTDGSIGGDEAPLPGHRPP----IWAI---QARLRS 290
            ||||...:..:         |....|| .||.|    :|..   .|||.|
Frog   305 CPLCMYDILDS---------GTPPRPL-AHRAPSQTQLWGRYPGSARLMS 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Znrf4	NP_001020049.1	Peptidases_S8_S53	31..>93	CDD:299169	16/76 (21%)
Znrf4	NP_001020049.1	zf-RING_2	207..252	CDD:290367	21/46 (46%)
rnf43	XP_002935238.2	ZNRF_3_ecto	80..182	CDD:375639	20/115 (17%)
		HRD1	<244..366	CDD:227568	38/113 (34%)
		RING-H2_RNF43_like	267..311	CDD:319580	22/45 (49%)
		RING-H2 finger (C3H2C3-type)	268..308	CDD:319580	20/41 (49%)
		DUF4573	523..643	CDD:373595
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920