DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ckma and Argk

DIOPT Version :9

Sequence 1:	NP_571007.2	Gene:	ckma / 30095	ZFINID:	ZDB-GENE-980526-109	Length:	381	Species:	Danio rerio
Sequence 2:	NP_729446.1	Gene:	Argk / 39041	FlyBaseID:	FBgn0000116	Length:	562	Species:	Drosophila melanogaster

Alignment Length:	358	Identity:	164/358 - (45%)
Similarity:	225/358 - (62%)	Gaps:	17/358 - (4%)

- Green bases have known domain annotations that are detailed below.

Zfish    16 VDEEYPDL--SKHNNHMAKVLTKEMYGKLRDKQTST-GFTVDDVIQTGVDNPGHPFIMTVGCVAG 77
            ::|.|..|  |...:.:.|.||||::..|::|.|.| ..|:.||||:|::|  |.  ..||..|.
  Fly   216 LEEGYAKLAASDSKSLLKKYLTKEVFDNLKNKVTPTFKSTLLDVIQSGLEN--HD--SGVGIYAP 276

Zfish    78 DEESYEVFKDLFDPVISDRHGGYKATDKHKTDLNFENLKGGDDLDP--NYVLSSRVRTGRSIKGY 140
            |.|:|.||.|||||:|.|.|||:|.||||... ||.::....::||  .||:|:|||.|||::||
  Fly   277 DAEAYTVFADLFDPIIEDYHGGFKKTDKHPAS-NFGDVSTFGNVDPTNEYVISTRVRCGRSMQGY 340

Zfish   141 ALPPHNSRGERRAVEKLSVEALSSLDGEFKGKYYPLKSMTDAEQEQLIADHFLFDKPVSPLLLAA 205
            ...|..:..:.:.:|......||.|:||.|||:|||..|..|.|:|||.||||| |.....|.||
  Fly   341 PFNPCLTEAQYKEMESKVSSTLSGLEGELKGKFYPLTGMEKAVQQQLIDDHFLF-KEGDRFLQAA 404

Zfish   206 GMARDWPDARGIWHNENKTFLVWVNEEDHLRVISMQKGGNMKEVFKRFCVGLQRIEEIFKKHNHG 270
            ...|.||..|||:||:.||||||.|||||||:||||:||::.:::||....:..||:     ...
  Fly   405 NACRFWPSGRGIYHNDAKTFLVWCNEEDHLRIISMQQGGDLGQIYKRLVTAVNEIEK-----RVP 464

Zfish   271 FMWNEHLGFVLTCPSNLGTGLRGGVHVKLPKL-STHAKFEEILTRLRLQKRGTGGVDTASVGGVF 334
            |..::.|||:..||:||||.:|..||:|:||| |..||.||:..:..||.|||.|..|.:.|||:
  Fly   465 FSHDDRLGFLTFCPTNLGTTIRASVHIKVPKLASNKAKLEEVAAKYNLQVRGTRGEHTEAEGGVY 529

Zfish   335 DISNADRIGSSEVEQVQCVVDGVKLMVEMEKKL 367
            ||||..|:|.:|.|.|:.:.||:..::::||.|
  Fly   530 DISNKRRMGLTEFEAVKEMYDGITELIKLEKSL 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ckma	NP_571007.2	creatine_kinase_like	17..373	CDD:153076	164/357 (46%)
Argk	NP_729446.1	arginine_kinase_like	215..562	CDD:153079	163/356 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581296
Domainoid	1	1.000	198	1.000	Domainoid score	I3023
eggNOG	1	0.900	-	-		E1_COG3869
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	288	1.000	Inparanoid score	I2808
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287050at33208
OrthoFinder	1	1.000	-	-		FOG0000437
OrthoInspector	1	1.000	-	-		mtm6403
orthoMCL	1	0.900	-	-		OOG6_100675
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2592
SonicParanoid	1	1.000	-	-		X315
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.690