DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slc39a7 and Catsup

DIOPT Version :9

Sequence 1:	NP_571006.3	Gene:	slc39a7 / 30094	ZFINID:	ZDB-GENE-991110-20	Length:	444	Species:	Danio rerio
Sequence 2:	NP_524931.1	Gene:	Catsup / 48805	FlyBaseID:	FBgn0002022	Length:	449	Species:	Drosophila melanogaster

Alignment Length:	483	Identity:	245/483 - (50%)
Similarity:	302/483 - (62%)	Gaps:	85/483 - (17%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MRVFSKSLLLIAVG-ILMSQQTL--------------------------AHSHHHHGHGDGGCHG 38
            ::::.|..|::.:| :|.|...|                          |..||||.      |.
  Fly    13 LQLYQKLALVVILGAVLFSLPALCAGQGNPSFKYSREANENFDPQKAPRAEHHHHHD------HD 71

Zfish    39 HSHGGAKMHHGASKWSAEANLPHAEEEHHVHDHGHTHNHAHDHGHAHSHGDIHDHGHAHKHGHAH 103
            |.||    ||                 ||.|||.|.|:|.||||| |.||  |||.|.|.||| |
  Fly    72 HDHG----HH-----------------HHGHDHDHDHDHGHDHGH-HHHG--HDHDHDHDHGH-H 111

Zfish   104 DHGAE----KSKKVVEAGKRNMVELWMQAIGATLLISAAPFLILFLIPVQSNTDQHQNLLKVLLS 164
            .||.:    |:|..::     |..:|:.:||:|||||||||::|::||: .|::..:..|||||:
  Fly   112 HHGHDERHTKAKPDLD-----MSTIWLHSIGSTLLISAAPFVLLYIIPL-DNSEAMKPRLKVLLA 170

Zfish   165 FASGGLLGDAFLHLIPHALEPHSH--HSQPHSEESHGQSHGEESHGHSHGAAHGHMMSVGLWVLG 227
            ||||||||||||||||||..||||  |...|..:.|....|||   |.||  |.|.||:||||||
  Fly   171 FASGGLLGDAFLHLIPHATHPHSHGEHGHDHGHDHHHHHDGEE---HEHG--HSHDMSIGLWVLG 230

Zfish   228 GIVAFLVVEKFVRLLKGGH-SHSHSHSPSAP-----KSKDSDEEDDKKGQKKGEKDKVVSQQKPT 286
            ||:|||.|||.||:||||| .|.|||....|     |.|.||:||...|.|..:..|:    |..
  Fly   231 GIIAFLSVEKLVRILKGGHGGHGHSHGAPKPKPVPAKKKSSDKEDSGDGDKPAKPAKI----KSK 291

Zfish   287 KKTVETSSDIKVSGYLNLAADFTHNFTDGLAIGASFLVGPAVGAVTTITILLHEVPHEIGDFAIL 351
            |...|...::::||||||||||.||||||||||||:|.|.::|.|||||||||||||||||||||
  Fly   292 KPEAEPEGEVEISGYLNLAADFAHNFTDGLAIGASYLAGNSIGIVTTITILLHEVPHEIGDFAIL 356

Zfish   352 VQSGCTKRKAMCLQLLTAVGALAGTACSLLAEGVGDAATAWILPFTAGGFVYIATVTVLPELLAG 416
            ::|||::||||.|||:||:|||||||.:||..|.||.:..|:||||||||:|||||:||||||..
  Fly   357 IKSGCSRRKAMLLQLVTALGALAGTALALLGAGGGDGSAPWVLPFTAGGFIYIATVSVLPELLEE 421

Zfish   417 HSSFWQSLLEILALLFGVGMMVLIAEYE 444
            .:...|||.||.|||.||.:|::||::|
  Fly   422 STKLKQSLKEIFALLTGVALMIVIAKFE 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slc39a7	NP_571006.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..112		38/91 (42%)
		Zip	122..441	CDD:308248	195/326 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..214		13/30 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..292		18/52 (35%)
Catsup	NP_524931.1	Zip	129..446	CDD:280666	195/326 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595808
Domainoid	1	1.000	267	1.000	Domainoid score	I1834
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I2434
OMA	1	1.010	-	-		QHG57827
OrthoDB	1	1.010	-	-		D548499at33208
OrthoFinder	1	1.000	-	-		FOG0001345
OrthoInspector	1	1.000	-	-		oto39481
orthoMCL	1	0.900	-	-		OOG6_103840
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1954
SonicParanoid	1	1.000	-	-		X2900
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.840