DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vdra and Hr96

DIOPT Version :9

Sequence 1:	NP_570994.1	Gene:	vdra / 30076	ZFINID:	ZDB-GENE-000210-31	Length:	453	Species:	Danio rerio
Sequence 2:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster

Alignment Length:	742	Identity:	147/742 - (19%)
Similarity:	222/742 - (29%)	Gaps:	373/742 - (50%)

- Green bases have known domain annotations that are detailed below.

Zfish    53 PPICGVCGDKATGFHFNAMTCEGCKGFFRRSMKRKASFTCPFNGNCTITKDNRRHCQACRLKRCI 117
            |..|.||||||.|::|||:|||.||.||||:...|..||||||.||.||...||.||.|||::|:
  Fly     4 PKNCAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQNCDITVVTRRFCQKCRLRKCL 68

Zfish   118 DIGMMKEFILTDE---------EVQRKKDLIMKR----------KEEE----------------- 146
            ||||..|.|:::|         |..|.|..:|:.          :|.:
  Fly    69 DIGMKSENIMSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNLDHYSG 133

Zfish   147 -----------------AAREARKPRLS-------------------DEQMQIINSLVEAHHKTY 175
                             :.|:|..|...                   |...|.||.|:....:..
  Fly   134 SQDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQAINRLMRTQKEAI 198

Zfish   176 D--------------------------------------------------------------DS 178
            .                                                              ||
  Fly   199 SVMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNALTVFTKFMSSPTDGVEIISKIVDS 263

Zfish   179 YSDFVRF-----------------------------------------------RPPVREGPVTR 196
            .:|.|.|                                               :|.:.:.|..:
  Fly   264 PADVVEFMQNLMHSPEDAIDIMNKFMNTPAEALRILNRILSGGGANAAQQTADRKPLLDKEPAVK 328

Zfish   197 SASRAASLHSL-------------SDASSDSFNHSP----------------------------- 219
            .|:.|....::             .||:.|...|||
  Fly   329 PAAPAERADTVIQSMLGNSPPISPHDAAVDLQYHSPGVGEQPSTSSSHPLPYIANSPDFDLKTFM 393

Zfish   220 -------------------ESV------------------------------------------- 222
                               |||
  Fly   394 QTNYNDEPSLDSDFSINSIESVLSEVIRIEYQAFNSIQQAASRVKEEMSYGTQSTYGGCNSAANN 458

Zfish   223 -----------------DTKLNFS-----------------------NLLMMYQDSGSPDSSEED 247
                             |.:||.:                       :.|||..|...||.:..:
  Fly   459 SQPHLQQPICAPSTQQLDRELNEAEQMKLRELRLASEALYDPVDEDLSALMMGDDRIKPDDTRHN 523

Zfish   248 QQSRLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLRSNQSFSLEDM 312
            .:     |..|.:|.:.:|:::|..||.|..|||:..|||:||||....|::::||...:..:..
  Fly   524 PK-----LLQLINLTAVAIKRLIKMAKKITAFRDMCQEDQVALLKGGCTEMMIMRSVMIYDDDRA 583

Zfish   313 SWSCGGPDFKYCINDVTKAGHTLE----LLEPLVKFQVGL-------------KKLKLHEEEHVL 360
            :|               |..||.|    :...|:||..|.             :|.::.|...::
  Fly   584 AW---------------KVPHTKENMGNIRTDLLKFAEGNIYEEHQKFITTFDEKWRMDENIILI 633

Zfish   361 LMAICLLSPDRPGV--QDHVRIEALQDRLCDVLQAYIRIQHPG--GRLLYAKMIQKLADLRSLNE 421
            :.||.|.:..|..|  :|.:|:|  |:....:|:.|:...:.|  .|..:.|:|||::|:..||:
  Fly   634 MCAIVLFTSARSRVIHKDVIRLE--QNSYYYLLRRYLESVYSGCEARNAFIKLIQKISDVERLNK 696

Zfish   422 EHSKQYRSLSFQPEHSMQLTPLVLEVF 448
            .....|  |:..|.   |:.||:.|:|
  Fly   697 FIINVY--LNVNPS---QVEPLLREIF 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vdra	NP_570994.1	NR_DBD_VDR	48..154	CDD:143513	54/153 (35%)
		Hinge	129..158		9/100 (9%)
		NR_LBD_VDR	156..452	CDD:132731	92/586 (16%)
		Vitamin D3 binding	255..265		3/9 (33%)
		Interaction with coactivator LXXLL motif	274..292		10/17 (59%)
		Vitamin D3 binding	299..306		2/6 (33%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P11473	442..450		4/7 (57%)
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	49/92 (53%)
		NR_LBD	462..>573	CDD:299703	28/115 (24%)
		NR_LBD_F1	523..702	CDD:132727	52/200 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6716
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I4089
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153746at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6384
SonicParanoid	1	1.000	-	-		X988
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	8.100