DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbx4 and byn

DIOPT Version :9

Sequence 1:	NP_570989.2	Gene:	tbx4 / 30070	ZFINID:	ZDB-GENE-991124-5	Length:	543	Species:	Danio rerio
Sequence 2:	NP_524031.2	Gene:	byn / 39349	FlyBaseID:	FBgn0011723	Length:	697	Species:	Drosophila melanogaster

Alignment Length:	570	Identity:	172/570 - (30%)
Similarity:	260/570 - (45%)	Gaps:	122/570 - (21%)

- Green bases have known domain annotations that are detailed below.

Zfish    13 GMTVAQSGGRPELASDSSH--LGLPTTPSNPQNNEPDQSIENIKVVLHDRELWKKFHEAGTEMII 75
            |...|.|||...::.:..|  :|...:|     ||.|:   |:::.|.|||||.:|.....|||:
  Fly    53 GGVAAVSGGGASVSGNGGHRVVGGAGSP-----NELDR---NLRISLDDRELWLRFQNLTNEMIV 109

Zfish    76 TKAGRRMFPSYKVKVTGMNPKTKYILLTDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDS 140
            ||.||||||..|:..:|::|...|.:|.:.|..|.||:|:.:.:|:..||||......:||||:|
  Fly   110 TKNGRRMFPVVKISASGLDPAAMYTVLLEFVQIDSHRWKYVNGEWVPGGKAEVPPSNPIYVHPES 174

Zfish   141 PATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTAYCTHVF 205
            |..|||||::.:||.|:||||. .:..|.|:|||:|||:||:|:|:.      ||:.....|:.|
  Fly   175 PNFGAHWMKEPISFAKVKLTNK-TNGNGQIMLNSLHKYEPRVHLVRV------GSEQRHVVTYPF 232

Zfish   206 HETAFISVTSYQNHKITQLKIENNPFAKGFRGSDEGDLRVSRLQGKD------YPVISKNMVRQR 264
            .||.||:||:|||.::|.|||:.|||||.|..:.|   |...|...|      .|..:.......
  Fly   233 PETQFIAVTAYQNEEVTSLKIKYNPFAKAFLDAKE---RPDTLYPHDTHYGWLIPPPTHYTAAAA 294

Zfish   265 LISSHGHLSGKLSAGVLSSHPQVLSHYQYDSGVPLPNSDSQEALSNSFTS-SREPSLLYHCFKHR 328
            .:::...||...|.|:::|.|.|.|    ...|...:..|.:....|.:| |..|:        |
  Fly   295 AVAAPPPLSIAQSHGLVASCPSVSS----AESVGPSSGGSCDRYGRSLSSRSVAPT--------R 347

Zfish   329 DNPRHLELGCKRPYL----DTTSSAVSEEHYFRSPPSY-DSPLLSHPYCNEALGSREACMYGGLE 388
            ..|      ..||.:    .:..||.:.......|||. .:|...|   :.:.||    :...:.
  Fly   348 TTP------YSRPRVVSGSGSNGSAGNASSTSPQPPSAPQTPTSLH---STSTGS----VSTSVS 399

Zfish   389 GEGGGAVGTDDLPAPSLNCNMWASVQPYPRYGMQTVEA----------MQYQPFTAHFNSTA--- 440
            ...||.:|:    |||..|  ::|  .|.:.|..:|:|          ..:|....::|:|:
  Fly   400 SSSGGGIGS----APSTGC--FSS--SYAQSGFMSVDASPTASVFSYPSSWQSNGNYWNATSVPG 456

Zfish   441 -------SAASMVSHHSPSMQRPHPTPPDLVTFTTQRVLPPTPSSASTSPSGSGHHDRAHSSLFH 498
                   |..::.||:|||     ||             ..:||..::|||.:.||...||..::
  Fly   457 PMPMNVCSGRNISSHNSPS-----PT-------------NGSPSYTTSSPSYTIHHLTPHSHQYN 503

Zfish   499 R-----------------KAGSPLRSQRDFTGYSTHSPTPTREPAYQYQT 531
            .                 ..||| ::......:..:.|||| .|.:|..|
  Fly   504 MAQTDIYGTGVGVGGGAGTTGSP-QAAYGAAAHQVYHPTPT-SPTHQLYT 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbx4	NP_570989.2	TBOX	52..240	CDD:238106	87/187 (47%)
byn	NP_524031.2	TBOX	86..268	CDD:238106	88/191 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810