DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RAX and Rx

DIOPT Version :9

Sequence 1:	NP_038463.2	Gene:	RAX / 30062	HGNCID:	18662	Length:	346	Species:	Homo sapiens
Sequence 2:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	370	Identity:	125/370 - (33%)
Similarity:	138/370 - (37%)	Gaps:	188/370 - (50%)

- Green bases have known domain annotations that are detailed below.

Human   133 KKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQEKL 197
            ||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||.
  Fly   556 KKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKS 620

Human   198 EVSSMKLQDSPLLSFSRSPPSATLSPLGAGPGSGGGPAGGALPLESWLGPPLPGGGATALQSLPG 262
            |  |::|   .|..|::.|     ..||.|       |.| ||::.||.|||       |.:|||
  Fly   621 E--SLRL---GLTHFTQLP-----HRLGCG-------ASG-LPVDPWLSPPL-------LSALPG 660

Human   263 F------------GPPAQSLPASYT------------------------------PPPPPPPF-- 283
            |            .||....|.:.|                              |||||||.
  Fly   661 FLSHPQTVYPSYLTPPLSLAPGNLTMSSLAAMGHHHAHNGPPPPHVGHGGHGQPQPPPPPPPHGV 725

Human   284 ----------------------------LNSP-----PLGPGLQPLAPP---------------- 299
                                        |.||     |||..|....||
  Fly   726 PHPHGSHHVVPLSHLSPHLSRMSPHATSLGSPHHGVTPLGTPLHSSLPPSSTATTVAVSSSQSSS 790

Human   300 ----------------------------------------------------------------- 299

  Fly   791 SSASLECSGPDVCMSPQNLSIGNADSNGDGRDLSSDLDAGSTSSNPGSSLDKCAASANIELLDVG 855

Human   300 ---PPSYPCGPGFGDKFPLDEADPRNSSIAALRLKAKEHIQAIGK 341
               ||..|...|.|...|  ..|.|::|||.||:|||||:..:.|
  Fly   856 RDSPPPPPTPTGKGSSTP--PTDMRSNSIATLRIKAKEHLDNLNK 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAX	NP_038463.2	Octapeptide motif	33..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..145		11/11 (100%)
		Homeobox	140..192	CDD:278475	50/51 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..318		52/284 (18%)
		OAR	319..335	CDD:281777	10/15 (67%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	323..336		9/12 (75%)
		Nuclear localization signal. /evidence=ECO:0000255	329..333		2/3 (67%)
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	50/51 (98%)
Rx	NP_726006.3	OAR	876..892	CDD:281777	10/15 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I5823
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	1	1.000	-	-		otm42185
orthoMCL	1	0.900	-	-		OOG6_106944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2565
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850